GnRH agonists for Endometriosis and Fibroids: Understanding the Science, Interpreting the Evidence, and Applying the Guidelines

Speciality: Obstetrics & Gynaecology


Speaker:

Akhil S | Consultant Obstetrician & Gynaecologist

Description:

Welcome to today’s episode, where we unravel the science behind GnRH agonists for endometriosis and fibroids. GnRH agonists work by lowering oestrogen levels, which helps reduce pain and shrink tissue growth associated with these conditions. Recent evidence shows they can be effective, especially for women who haven’t responded to other treatments. However, side effects—like menopausal symptoms and bone density loss—require careful consideration. Current guidelines recommend using GnRH agonists for a limited period, often alongside add-back therapy to minimise side effects. By understanding the science and interpreting the evidence, clinicians and patients can make informed decisions about managing endometriosis and fibroids.

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