Is Lenalidomide Resistance in Myeloma Reversible with JAK Inhibition?

Published Date: 25 Dec 2023

Ruxolitinib's early-stage experience points to a possible role in relapsed or resistant diseases.

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Oral drug combination extends progression-free survival in advanced ER-positive breast cancer

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Latest News

Researchers from Rutgers Health and other institutions have discovered why a powerful leukemia drug eventually fails in most patients—and found a potential way to overcome that resistance.

About half of women over 40 have dense breasts. The denser the breast tissue, the more difficult it is to spot cancer on a standard mammogram. Having dense breast tissue can make it harder to detect cancer and sometimes leads ...

In recent research, treatment with osimertinib plus a platinum–pemetrexed chemotherapy combination resulted in statistically significant and clinically meaningful improvement in overall survival in patients with newly diagnosed ...

Former UK prime minister Rishi Sunak has called for a targeted prostate cancer screening program for men most at high risk of the disease, reviving a national debate on how to save more lives and tackle health inequalities ...

The ultimate cause of death from cancer may not be metastatic disease, as researchers have long surmised, but an infiltration of tumors into major blood vessels that cause blood clots and multiorgan failure, a one-of-a-kind ...

A new fast and convenient approach to scintigraphy-based monitoring allows physicians to efficiently and reliably assess prostate cancer progression or regression during treatment. With this strong prognostic information, ...

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Nuclear missile workers are contracting cancer: They blame the bases

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Immune cell homing hydrogel-based platform captures dendritic cells to process mRNA from cancer vaccines

A research team led by Cancer Center at Illinois (CCIL) member Hua Wang has published new research detailing a new mRNA cancer vaccine platform. The study introduces an immune cell homing hydrogel-based platform designed ...

A radiotheranostic approach designed to combat aggressive cancers

UCLA scientists, together with a team of international collaborators, have identified a promising new treatment strategy that can detect, kill and reprogram aggressive, treatment-resistant tumors like osteosarcomas and glioblastoma.

Exercise may help breast cancer survivors manage weight

New UBC Okanagan research shows that exercise can do more than improve the strength and cardiovascular endurance of women who have survived breast cancer.

Study recommends new grading system for invasive squamous cell carcinoma of the lung

Invasive lung squamous cell carcinoma (LUSC) accounts for approximately one-quarter of all lung cancers, but therapeutic options for LUSC remain limited, primarily due to the absence of well-defined, targetable molecular ...

Q&A: Breast cancer facts that could save lives

October is Breast Cancer Awareness Month, a time to spotlight a disease that will affect hundreds of thousands of Americans this year. In the U.S., a new case of breast cancer is diagnosed about every two minutes, with more ...

Neural networks and label-free microscopy enable accurate detection of pancreatic tumors

Pancreatic neuroendocrine neoplasms (PNENs) are a rare form of cancer that affects hormone-producing cells in the pancreas. Although uncommon, their incidence has been rising steadily over the past few decades.

Lesser-known lobular breast cancer on the rise in U.S. women

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Patients value communication skills from cancer surgeons across six key areas, according to research

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Drop in credit score after cancer diagnosis linked to increased mortality

Patients with cancer whose credit scores decline after their diagnosis face a significantly higher risk of mortality, providing the first objective data linking financial health to physical survival.

A healthier lifestyle after bowel screening shown to prevent bowel cancer

If you adopt a healthier lifestyle after bowel screening, it can lower your risk of both bowel cancer and other chronic diseases, a new study shows.

Analysis of NRG trial in limited-stage small cell lung cancer suggests QOL benefit with twice- vs. once-daily radiation

Previously, the primary endpoint results of the NRG-LU005 study assessing the addition of the immunotherapy drug atezolizumab to standard of care concurrent chemoradiation for limited-state small cell lung cancer were reported ...

Herpes virus-based vaccine shows promise in targeting tumors without side effects

The Herpes simplex virus is a widespread virus that often causes cold sores, and most people carry it. By removing a virulence gene, i.e. a gene that makes the virus harmful to humans, the herpes virus can be repurposed as ...

Zebrafish models offer fast, effective guidance for personalized therapies for kids with high-risk cancer

Molecular profiling has transformed cancer care, but 30% of high-risk pediatric cancers do not have actionable therapeutic targets, limiting personalized treatment options and negatively affecting survival outcomes.

Women who miss their first mammogram face higher risk of breast cancer death, study finds

Women who miss their first mammogram run a higher risk of being diagnosed with advanced breast cancer and dying from the disease. This is shown in a new study from Karolinska Institutet published in BMJ.

Cancer deaths expected to rise to over 18 million in 2050, nearly 75% more than in 2024

There has been a rapid increase in the global number of cancer cases and deaths between 1990 and 2023, despite advances in cancer treatment and efforts to tackle cancer risk factors over that same time period.

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