10 Medical Breakthroughs Transforming Clinical Care

Published Date: 27 May 2026

CRISPR cures for sickle cell disease, gene therapy for hemophilia A, and expanding CAR T cell uses point to a new era of potentially curative, personalized treatments.

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Vaccinated Woman With COVID Rebound After Ensitrelvir

A possible first case of COVID recurrence after ensitrelvir: a vaccinated woman whose antigen levels fall and then rebound, with symptoms returning 1 day after treatment.

Optimizing UC Therapy in the Presence of Comorbidities

Dr Corey Siegel discusses the importance of individualized therapy selection for ulcerative colitis in the presence of comorbidities.

ESMO Update: New Guidance for Rare Uveal Melanoma

Dr Teresa Amaral breaks down the essential new guidelines for uveal melanoma. Stay ahead of the latest standards in patient care.

A New Ultrapotent Opioid Emerges: What Is Cychlorphine?

Dr Robert Glatter speaks with toxicologist Dr Lewis Nelson about cychlorphine, a newly emerging synthetic opioid linked to fatal overdoses, and what clinicians should understand about detection, naloxone response, and the evolving drug landscape.

Soccer ‘Headers’ Acutely Raise Brain Damage Biomarkers

Study findings are concerning, but will the world’s most popular sport ban the practice of heading the ball?

Lipid Guidelines: Four Major Concerns

Too many Class I recommendations lacking supporting data from randomized trials and intellectual conflicts of interest are among John Mandrola’s complaints about the ACC/AHA guidelines on dyslipidemia.

Todays Updates

What Your ZIP Code Is Costing You

Forget salary. The cities winning the physician satisfaction race are playing a completely different game.

Don't Blame COVID for Diabetes 'Surge' in Kids

The prevalence of type 2 diabetes is rising among US youth, and if we don’t address the real causes, we really will see a potentially unstoppable surge.

Coconut Oil

Current evidence supports the use of this botanical agent to promote skin health, but more research is needed to ascertain more varied and curative applications for this popular natural product.

Imaging and Staging Essentials in Uveal Melanoma

Dr Teresa Amaral reviews new uveal melanoma guidelines, focusing on AJCC 8th Edition staging, the Liverpool prognostic tool, and the essential role of BAP1 and PRAME expression.

Red Cross Mourns Death of Three Volunteers From Ebola

The Red Cross on Saturday paid tribute to three volunteers who ⁠are believed to have died after contracting Ebola while handling bodies.

US Adds Atlanta Area Airport for Ebola Screening, CDC Says

Americans coming back from the Democratic Republic of the Congo, ⁠Uganda or South Sudan now have a second entry point for returning ⁠to the United States, with the CDC on...

US FDA Advisers to Weigh Updating 2026-27 COVID Vaccines for XFG Variant

Advisers to the U.S. Food and Drug Administration will discuss whether COVID-19 vaccines should be updated to target the latest circulating XFG ⁠subvariant for the 2026-27...

Todays Updates

What Your ZIP Code Is Costing You

Forget salary. The cities winning the physician satisfaction race are playing a completely different game.

Don't Blame COVID for Diabetes 'Surge' in Kids

The prevalence of type 2 diabetes is rising among US youth, and if we don’t address the real causes, we really will see a potentially unstoppable surge.

Coconut Oil

Current evidence supports the use of this botanical agent to promote skin health, but more research is needed to ascertain more varied and curative applications for this popular natural product.

Imaging and Staging Essentials in Uveal Melanoma

Dr Teresa Amaral reviews new uveal melanoma guidelines, focusing on AJCC 8th Edition staging, the Liverpool prognostic tool, and the essential role of BAP1 and PRAME expression.

Red Cross Mourns Death of Three Volunteers From Ebola

The Red Cross on Saturday paid tribute to three volunteers who ⁠are believed to have died after contracting Ebola while handling bodies.

US Adds Atlanta Area Airport for Ebola Screening, CDC Says

Americans coming back from the Democratic Republic of the Congo, ⁠Uganda or South Sudan now have a second entry point for returning ⁠to the United States, with the CDC on...

US FDA Advisers to Weigh Updating 2026-27 COVID Vaccines for XFG Variant

Advisers to the U.S. Food and Drug Administration will discuss whether COVID-19 vaccines should be updated to target the latest circulating XFG ⁠subvariant for the 2026-27...

Latest News

A possible first case of COVID recurrence after ensitrelvir: a vaccinated woman whose antigen levels fall and then rebound, with symptoms returning 1 day after treatment.

Dr Corey Siegel discusses the importance of individualized therapy selection for ulcerative colitis in the presence of comorbidities.

Dr Teresa Amaral breaks down the essential new guidelines for uveal melanoma. Stay ahead of the latest standards in patient care.

Dr Robert Glatter speaks with toxicologist Dr Lewis Nelson about cychlorphine, a newly emerging synthetic opioid linked to fatal overdoses, and what clinicians should understand about detection, naloxone response, and the evolving drug landscape.

Study findings are concerning, but will the world’s most popular sport ban the practice of heading the ball?

Too many Class I recommendations lacking supporting data from randomized trials and intellectual conflicts of interest are among John Mandrola’s complaints about the ACC/AHA guidelines on dyslipidemia.

News All Time

Updates in Ovarian Cancer From SGO 2026

Landmark survival gains in ROSELLA and KEYNOTE-B96 in platinum-resistant disease plus pivotal data in low-grade serous ovarian cancer are highlights from SGO 2026, reported by Dr Amelia Jernigan.

A Primary Care Primer on Alzheimer’s Blood Tests

Alzheimer’s management may slowly be making its way to primary care, so The Curbsiders unpack the latest on blood-based biomarkers and antiamyloid therapies.

S3 Episode 3: Endometrial Cancer: Research, Early Detection, and Treatment

Drs Ursula Matulonis and Jessica St. Laurent discuss endometrial cancer research, funding, early detection, and treatment, including the impact of GLP-1 receptor agonists.

MASH Screening Made Simple: A 4-Step Guide

MASH is incredibly common, but easily missed. Dr Neil Skolnik breaks down the new AGA clinical pathway to help PCPs confidently screen and treat patients.

Differential Diagnosis of Suspected Pulmonary Fibrosis and Efficacy of Approved Therapies

Experts review the differential diagnosis of suspected IPF, highlighting how a multidisciplinary approach confirmed the diagnosis and informed selection of optimal antifibrotic therapy.

Adult With Established RA and Symptoms of ILD/PPF

A 50-year-old man with rheumatoid arthritis and symptoms of interstitial lung disease or progressive pulmonary fibrosis is evaluated by experts. Treatment options and care priorities are discussed.

S4 Episode 3: How Much Monitoring Is Enough in Psoriasis Care?

Dr Steven Feldman joins Drs Jennifer Cather and Brad Glick to discuss how much monitoring systemic psoriasis treatments really require in modern practice.

The Half-Life of Medical Certainty

Medical knowledge is always evolving. For his 100th column, Dr Kenny Lin reflects on how his views on cancer screening, blood pressure, and health policy have changed.

Infographic: How Much a Doctor’s Average Pay in the US Rose

On average, a physician in the US earned 3% more in 2025, a Medscape survey found. There was no major difference in compensation gains for primary care doctors vs specialists.

Early Multimodal Therapy Restores Hairline in a Woman

A 36-year-old woman with a 2-year history of hairline recession and eyebrow thinning shows marked regrowth after early multimodal therapy with dutasteride, tofacitinib, and intralesional steroids.

Man With Spinal Compression From Hepatocellular Carcinoma

The cervical biopsy was nondiagnostic despite imaging and PET suggesting aggressive disease; a targeted lumbar biopsy ultimately confirmed metastatic hepatocellular carcinoma.

From Pixels to Prescriptions: AI in Oncology Pathology

Digital pathology AI is moving from detection to treatment decisions. In part 2 of this series, here’s what’s FDA-cleared — and how it changes care in oncology practice.

Woman With Lateral Neck Cyst From Fourth Branchial Cleft

An uncommon congenital fourth branchial cleft cyst presents after exercise as a painless, mobile posterior neck mass, highlighting the need for prompt imaging and surgery.

A Man With Severe Gallbladder Dyskinesia

Severe gallbladder dysfunction may present without stones: a case of EF 2% on HIDA in a patient with fatty-meal pain whose pathology showed mild chronic cholecystitis.

Early PsA Detection: Biomarkers and Genetics

Dr Vinod Chandran discusses biomarkers, genetics, and clinical features that assess risk for psoriatic arthritis.

Precision Nutrition for Better Clinical Outcomes

Precision nutrition integrates genetics, the gut microbiome, metabolomics and lifestyle data to tailor dietary therapy promising better clinical outcomes.

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