FDA review of dupilumab for chronic spontaneous urticaria

Published Date: 13 Mar 2023

The FDA approval request for CSU is based on data from a pair of Phase 3 trials in two different populations.

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Are We Training Doctors for the Systems They'll Inherit?

Medical exchanges with five health systems showed one medical student that the answer is no.

Hospitalists Face a Growing Risk for Decision-Making Fatigue

A combination of large patient load and ‘a million decisions a day’ can lead to poorer outcomes.

How Pharmacists Can Strengthen Drug Safety Monitoring

Pharmacists play a key role in spotting suspected adverse reactions early, even when the link to a medicine is uncertain.

Congenital Ichthyosis Tied to Risk for Allergic Disorders

Patients with congenital ichthyosis may have significantly higher rates of allergic rhinitis, food allergy, and allergic asthma than those in the general population, a survey finds.

Does CKD Severity Predict Adverse ICU Outcomes?

Among patients in the ICU, the presence and severity of chronic kidney disease are tied to a higher risk for mortality; among those who receive maintenance dialysis, the risk is comparatively lower.

Gram-Negative Bacteria Lead Pediatric Cancer BSIs

Gram-negative bacteria account for nearly 70% of bloodstream infections in pediatric oncology patients, with nonsusceptibility rates of some organisms to antibiotics increasing.

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Belgian Algorithm Reshapes Endometrial Cancer Care

A new Belgian algorithm may help clinicians choose adjuvant therapy more precisely in early endometrial cancer, moving beyond TNM staging alone.

Todays Updates

Belgian Algorithm Reshapes Endometrial Cancer Care

A new Belgian algorithm may help clinicians choose adjuvant therapy more precisely in early endometrial cancer, moving beyond TNM staging alone.

Latest News

Medical exchanges with five health systems showed one medical student that the answer is no.

A combination of large patient load and ‘a million decisions a day’ can lead to poorer outcomes.

Pharmacists play a key role in spotting suspected adverse reactions early, even when the link to a medicine is uncertain.

Patients with congenital ichthyosis may have significantly higher rates of allergic rhinitis, food allergy, and allergic asthma than those in the general population, a survey finds.

Among patients in the ICU, the presence and severity of chronic kidney disease are tied to a higher risk for mortality; among those who receive maintenance dialysis, the risk is comparatively lower.

Gram-negative bacteria account for nearly 70% of bloodstream infections in pediatric oncology patients, with nonsusceptibility rates of some organisms to antibiotics increasing.

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New Evidence Links Atopic Dermatitis to Herpes Zoster

A study of more than 13 million people in the UK finds an association between atopic dermatitis and herpes zoster, including after adjusting for comorbidities, treatments, and other factors.

Antiphospholipid Antibodies Linked to Pregnancy Risks in SLE

Certain antiphospholipid antibody profiles are associated with increased odds of adverse pregnancy outcomes in women with systemic lupus erythematosus.

Metabolic, Autoimmune Links Seen in Sclerosing Mesenteritis

Patients with symptomatic sclerosing mesenteritis often present with abdominal pain and have concurrent autoimmune, malignant, or metabolic disorders.

How Immigration Raids Emptied a Local Pediatric Clinic

Fear of immigration operations keeps vulnerable families away from the doctor, driving a sharp rise in missed appointments and leaving critical childhood care on hold.

Air Pollution Linked to Rise in RA Flares, Disease Activity

New research adds greater strength to previous findings that associate exposure to fine particulate matter with higher disease activity and flare risk in patients with rheumatoid arthritis.

This Is What mRNA Vaccines May Actually Do in the Body

Muscle cells, not just dendritic cells, help mRNA vaccines work, with big implications for vaccine and therapy design.

Arbovirus Surge Prompts CDC Warning for Anti-CD20s

Patients taking immune-suppressing therapies are at higher risk for neuroinvasive illness from ticks and mosquitoes.

Psychiatric Disorders Emerge Early in MOGAD

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Rabies in an 11-Year-Old Boy After Bat Contact

Early facial numbness and sore gums masked a deadly diagnosis in a boy who had direct bat contact but no obvious wound.

Wheat Sensitivity: Is Gluten the Only Trigger?

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Vitiligo Severity Assessments Vary Among HCPs

US and Europe healthcare providers describe inconsistent approaches to nonsegmental vitiligo severity, with quality of life, repigmentation, and progression influencing treatment decisions.

Schools Need Proactive Asthma Care Plans

Fewer than a third of children’s schools are equipped to manage emergent asthma exacerbations, a study shows.

Race and Language May Shape Kids’ Asthma ED Care

Race, gender, language, and chronic illness may influence hospital outcomes after an ED visit for asthma, but the standard social drivers of health indices miss geographic patterns behind it.

Deep Dive: PCSK9 Inhibitors: Five Agents, New Rules

An oral macrocyclic peptide has joined two monoclonal antibodies, an siRNA, and a monthly fusion protein. Ann Marie Navar, MD, PhD, on why that changes prescribing.

Abrocitinib Alters Skin Microbiome in Atopic Dermatitis

Treatment with abrocitinib is associated with reduced Staphylococcus aureus abundance and increased skin microbial diversity in patients with moderate-to-severe atopic dermatitis.

Experts: States Not Likely to Change Vaccine Policy After EO

An Executive Order implicitly threatened states that do not align with its recommendations, but experts say the administration would be on shaky legal ground.