FDA review of dupilumab for chronic spontaneous urticaria

Published Date: 13 Mar 2023

The FDA approval request for CSU is based on data from a pair of Phase 3 trials in two different populations.

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Patients with diabetes and related complications treated by emergency care services for acute illnesses face a higher risk for long-term mortality than those with diabetes but no complications.

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In high-risk low-grade glioma, starting with temozolomide or radiotherapy yields similar survival.

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Glioma Outcomes Shaped by Subtype More Than Tx Sequence

In high-risk low-grade glioma, starting with temozolomide or radiotherapy yields similar survival.

Stem Cell Transplant Associated With Better PFS in NKTCL

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Antibiotic treatment based on a urine culture may help reduce the occurrence of urinary tract infections after ureteroscopy in children with kidney or ureteral stones.

Patients with diabetes and related complications treated by emergency care services for acute illnesses face a higher risk for long-term mortality than those with diabetes but no complications.

Stem cell-derived dopamine cell transplantation appears feasible and may reduce medication needs in PD, but longer follow-up is needed to establish its clinical benefit and long-term safety.

SGLT2 inhibitor therapy is linked to significant reductions in BMI and systolic blood pressure in kidney transplant recipients with or without diabetes, an Italian study finds.

Antiepileptic drugs are linked to nearly one quarter of Stevens-Johnson syndrome and toxic epidermal necrolysis cases, a systematic review and meta-analysis finds.

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World Cup Injuries Test Sports Medicine

World Cup injuries can end careers in an instant, forcing physicians to balance elite performance demands with the long road to a safe return.

JAK Inhibitors Linked to Higher Cancer Risk Across IMIDs

JAK inhibitors are associated with a higher risk for malignancy than TNF inhibitors across immune-mediated inflammatory diseases, according to a meta-analysis.

Allergy to NSAIDs Confirmed in Only About 3 in 10 Children

Most children suspected of having an allergy to NSAIDs are not truly allergic to them, and in some, a food allergy triggered by the drug may be the real reason, warranting targeted workup.

Gaza Daily Hunt for Water Lays Bare Worsening Health Crisis

Health authorities warn that Gaza is facing an unprecedented collapse of its water and sanitation systems, with consequences that could last decades.

JAK Inhibitor Timing Affects Zoster Vaccine Response in RA

Immediate initiation of JAK inhibitor therapy after recombinant zoster vaccination is linked to lower early immune responses than delayed initiation in patients with rheumatoid arthritis.

Temocillin: Old Antibiotic Finds a New Role

Temocillin is non-inferior to carbapenems for resistant Enterobacterales bacteraemia, offering a safe, carbapenem-sparing treatment option for patients with the infection.

Cyclosporiasis: 3 Things to Know About Diagnosis, Management

Awareness, early recognition, and appropriate testing are key.

SLE Linked to Higher Risk for Mortality After Heart Attack

Systemic lupus erythematosus is associated with higher risks for all-cause and cardiovascular mortality for up to 5 years after acute myocardial infarction, a study finds.

What’s Driving Negligence Claims in the ED?

From safety netting to documentation, understanding the five themes driving claims in emergency departments could help to protect patients and doctors.

Aid Group Says Seven Americans Quarantining At Kenya Ebola Facility After US Travel Ban

Seven American aid workers who had been in Congo to fight the Ebola outbreak are quarantining at a new isolation facility in Kenya after the U.S. government introduced...

Are Women With Immune Diseases Missing Reproductive Care?

Fragmented multidisciplinary care and inconsistent guidance continue to create reproductive care gaps despite comprehensive recommendations across the reproductive life course.

Herb/Spice and Seed Allergies Often Begin in Childhood

Herb/spice and seed allergies often begin in childhood and can lead to severe anaphylaxis requiring epinephrine.

Women Physicians Push Back on Medicine’s Gender Pay Gap

It’s not getting better. From salary gaps to unpaid admin to lack of transparency, women physicians share how persistent inequity shapes the quality of their lives.

New Zealand Detects First H5N1 Bird Flu Case, Starts Vaccination Of Endangered Species

New Zealand reported its first case of the deadly H5N1 bird flu after a migratory seabird found on a beach near the capital, Wellington, tested positive, ⁠Biosecurity...

Clean Catheterization Matches Sterile for Related UTI Risk

A clean bladder catheterization technique is as effective as a sterile method.

Weighted Flare Score Predicts Organ Damage Risk in Lupus

A novel weighted flare score for systemic lupus erythematosus identifies high-risk disease flares, which are linked to the risk for subsequent organ damage.

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