FDA review of dupilumab for chronic spontaneous urticaria

Published Date: 13 Mar 2023

The FDA approval request for CSU is based on data from a pair of Phase 3 trials in two different populations.

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US radiologists vary substantially in their reading of low-dose CT lung cancer screens, highlighting a need for measures to help standardize interpretation.

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Researchers analyze individual patient data from five randomized phase 3 trials comparing PORT alone vs PORT plus hormone therapy in patients with recurrent prostate cancer.

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Among critically ill patients aged 90 and older, the source of sepsis may influence short-term survival more than previously recognized.

A decline in the functioning of the cellular cleanup pathway drives disease across nearly every organ. Now drugs that restore it are heading toward the clinic.

Ultraprocessed foods may do more than add calories, with emulsifiers, sweeteners, and dyes linked to gut dysbiosis and a weakened intestinal barrier.

Evidence points to a neuroimmune pathway through which psychological stress may amplify skin inflammation, raising questions about future approaches to eczema care.

Glomerular hematuria without proteinuria or impaired kidney function in patients with systemic lupus erythematosus may indicate pathology other than lupus nephritis, a study finds.

Nearly one third of children born very preterm have abnormal pulmonary findings at preschool age, with greater bronchodilator responsiveness and a higher burden of respiratory risk factors.

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Dupilumab significantly improves sinus opacification and disease burden in patients with allergic fungal rhinosinusitis.

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Dupilumab Shows Long-Term Benefits in CRSwNP

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Infection risk varies by biologic target, supporting tailored screening, vaccination, and monitoring rather than a one-size-fits-all prevention strategy.

New BTK Inhibitor Approved for Urticaria

MHRA approves oral BTK inhibitor remibrutinib, offering adults with chronic spontaneous urticaria a new option beyond antihistamines.

Uveitis May Flag Possibility of Axial Spondyloarthritis

Many patients with nongranulomatous acute anterior uveitis may be diagnosed with previously unrecognized axial spondyloarthritis after rheumatologic evaluation.

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