FDA review of dupilumab for chronic spontaneous urticaria

Published Date: 13 Mar 2023

The FDA approval request for CSU is based on data from a pair of Phase 3 trials in two different populations.

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Adrenal Crisis: Rare, Deadly, Preventable — Here’s How

Adrenal crisis remains rare but life-threatening. Better patient, family, and clinician education could help prevent deaths.

Psychosocial Factors May Improve ED Suicide Risk Prediction

Augmentation of data-based risk models with psychosocial factors obtained from clinical notes may improve the prediction of suicide attempts in patients with suicidal ideation, a study shows.

Mar 27 2026 This Week in Cardiology

Early aortic valve replacement in aortic stenosis, left atrial appendage occlusion in JAMA Cardiology, and a big preview of the upcoming American College of Cardiology meeting are the topics John Mandrola, MD, discusses in this week’s podcast.

South Carolina Could Declare Measles Outbreak Over by April 26, Health Official Says

South Carolina could declare its ongoing measles ⁠outbreak over by April 26 if no additional infections are reported, the state's ⁠top epidemiologist said during a briefing...

A Ubiquitous Alcohol Emerges as Allergen of 2026

Benzyl alcohol, though generally safe, can be a stealth cause of allergic dermatitis through a variety of exposures.

Allergic Rhinitis May Worsen Asthma Risk in CRS

Individuals with chronic rhinosinusitis face an elevated risk of developing new-onset asthma and subsequent exacerbations, and concurrent allergic rhinitis increases the risk.

Todays Updates

Insulin Resistance Detected Early May Guide HS Therapy

Screening for insulin resistance early after the diagnosis of hidradenitis suppurativa shows promise for guiding therapies to improve the disease course.

Dermatomyositis: Targeted Drug Shows Promise vs Placebo

At 52 weeks, the 30-mg daily oral dose of brepocitinib outperformed the 15-mg dose in a study of patients with dermatomyositis resistant to previous treatments.

Melasma: A New Era of Topical Treatment Options Galore

Combination therapies remain key as multiple agents for melasma hit the market.

LAAC an Alternative for NOAC in Lower-Risk AF Patients

CHAMPION-AF finds left atrial appendage closure and anticoagulation therapy for atrial fibrillation about equal but raises doubts about whether the former is a true alternative.

Fibrinolytic Beats Current Standard for Intermediate-Risk PE

For intermediate-risk pulmonary embolism, a low-dose fibrinolysis strategy reduced PE-related events by half with no significant increase in bleeding vs standard therapy.

PCKS9 Inhibitors Seen Driving Down LDL-C in Diabetes

A subgroup analysis of the VESALIUS-CV trial showed evolocumab significantly cut LDL cholesterol and cardiovascular event risk in people with diabetes but no known atherosclerosis.

High Dx Yield Supports Workup for INOCA

Performed with favorable safety, the diagnostic yield for coronary function testing in patients with ischemia but nonobstructive arteries was found to exceed 90%.

Todays Updates

Insulin Resistance Detected Early May Guide HS Therapy

Screening for insulin resistance early after the diagnosis of hidradenitis suppurativa shows promise for guiding therapies to improve the disease course.

Dermatomyositis: Targeted Drug Shows Promise vs Placebo

At 52 weeks, the 30-mg daily oral dose of brepocitinib outperformed the 15-mg dose in a study of patients with dermatomyositis resistant to previous treatments.

Melasma: A New Era of Topical Treatment Options Galore

Combination therapies remain key as multiple agents for melasma hit the market.

LAAC an Alternative for NOAC in Lower-Risk AF Patients

CHAMPION-AF finds left atrial appendage closure and anticoagulation therapy for atrial fibrillation about equal but raises doubts about whether the former is a true alternative.

Fibrinolytic Beats Current Standard for Intermediate-Risk PE

For intermediate-risk pulmonary embolism, a low-dose fibrinolysis strategy reduced PE-related events by half with no significant increase in bleeding vs standard therapy.

PCKS9 Inhibitors Seen Driving Down LDL-C in Diabetes

A subgroup analysis of the VESALIUS-CV trial showed evolocumab significantly cut LDL cholesterol and cardiovascular event risk in people with diabetes but no known atherosclerosis.

High Dx Yield Supports Workup for INOCA

Performed with favorable safety, the diagnostic yield for coronary function testing in patients with ischemia but nonobstructive arteries was found to exceed 90%.

Latest News

Adrenal crisis remains rare but life-threatening. Better patient, family, and clinician education could help prevent deaths.

Augmentation of data-based risk models with psychosocial factors obtained from clinical notes may improve the prediction of suicide attempts in patients with suicidal ideation, a study shows.

Early aortic valve replacement in aortic stenosis, left atrial appendage occlusion in JAMA Cardiology, and a big preview of the upcoming American College of Cardiology meeting are the topics John Mandrola, MD, discusses in this week’s podcast.

South Carolina could declare its ongoing measles ⁠outbreak over by April 26 if no additional infections are reported, the state's ⁠top epidemiologist said during a briefing...

Benzyl alcohol, though generally safe, can be a stealth cause of allergic dermatitis through a variety of exposures.

Individuals with chronic rhinosinusitis face an elevated risk of developing new-onset asthma and subsequent exacerbations, and concurrent allergic rhinitis increases the risk.

News All Time

Alpha-Gal Syndrome: For This Doctor, It’s Personal

After two decades tracking cases of the meat allergy, Tina Merritt, MD, urges greater awareness of cross-reactivity and gaps in labeling for mammalian-derived ingredients.

Young Canadians Lack Crucial Knowledge About HPV

Most young survey respondents perceive their understanding of human papillomavirus to be strong, but they tripped up when asked specific facts about the virus.

Infection Risk Surges Around Cirrhosis Diagnosis

Infection risk is elevated around the time of cirrhosis diagnosis vs years prior, with the elevated risk persisting post-diagnosis; the risk is notably higher in patients with decompensated cirrhosis.

Olmesartan-Induced Sprue Causes Diarrhea in a Woman

Recurrent severe diarrhea with acute kidney injury after drug reinitiation highlights a rare but serious enteropathy linked to antihypertensive therapy.

Victoria Pilots PA Program for Harm Reduction Workers

Harm reduction workers who bring lived experience to harm reduction programs may themselves need support for a substance use disorder.

Adrenaline Fails to Reverse Histamine-Induced Hypotension

Standard intramuscular adrenaline fails to reverse histamine‑induced hypotension in healthy adults, new research shows.

Data Support Ruxolitinib’s Safety for Eczema in Children

A long-term analysis offers reassurance to users of the topical treatment recently approved for children down to age 2.

Time to Rethink Early Morning In-Hospital Blood Draws?

Delaying in-hospital blood draws by just 2 hours helped sleep quality and quantity, researchers find. Now, some hospitals are considering a change to traditional timing.

Liver Enzyme Guides Prognosis in CKD Patients on Dialysis

Among patients with CKD, serum total ALP and its liver, bone, and intestinal fractions increase with disease severity, and liver ALP is associated with mortality in those undergoing haemodialysis.

‘I HATE YOU’ and Other Things People Say to Their Doctors

Patient rudeness, in-person or on the portal, is more common than ever, and data now show it’s taking a toll on quality care.

Medical Accuracy of 'The Pitt'

The cast and creators of HBO Max's 'The Pitt' explain how they get the medicine right, and why it matters.

COVID Shots in Pregnancy Protect Infants’ First 6 Months

The research adds important evidence for clinicians counseling pregnant patients.

Barzolvolimab Shows Persistent Benefits for CSU

Patients maintain their improvements off treatment, even after clearance of barzolvolimab, investigators report.

Specialty Care in Crisis in British Columbia

Long wait times for an appointment with a specialist and for treatment after the referral are putting lives at risk, experts say.

Review Finds Benefits of Biotic Therapy for Acne

‘It is theorized that probiotics improve skin barrier hydration through multiple mechanisms, including modulation of the skin microbiome,’ according to the authors.

FDA Withdraws Proposal to Prohibit Minors From Tanning Beds

‘Restricting teens’ access to indoor tanning and informing the public about the dangers of indoor tanning are critical to preventing skin cancer,’ AAD President Susan C. Taylor, MD, said.

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