COPD activates bitter taste receptors, the target of asthma treatment

Published Date: 17 Mar 2023

Germany: Activation of bitter taste receptors opens lung pathways, making them potential targets for the treatment of chronic lung diseases...

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Australia Confirms First H5N1 Bird Flu Case in Local Mammal

Australia on Sunday confirmed its first case of H5N1 bird flu in a mammal, with the deadly virus ⁠found in a long-nosed fur seal in South Australia state.

Nerandomilast Lowers Mortality Risk in Pulmonary Fibrosis

Nerandomilast is associated with reduced mortality risk in patients with pulmonary fibrosis, a pooled analysis of two trials shows.

Mastering the HER2 Spectrum for Individualized Management of Advanced/Metastatic NSCLC

Mastering the HER2 Spectrum for Individualized Management of Advanced/Metastatic NSCLC

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Expert Insights on the Next Wave of IO Combinations in mNSCLC

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Treating Advanced Disease With Bispecific ADCs: Mechanisms of Action and Therapeutic Rationale for Bispecific ADCs in Solid Tumors

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The 1-hour troponin pathway was safely implemented in a real-world study but did not impact workflow in busy emergency departments.

Edoxaban Falls Short After Intracranial Hemorrhage in AF

Edoxaban reduced ischemic stroke after intracranial hemorrhage in patients with AF, but excess hemorrhagic stroke and major bleeding offset the benefit.

Drug Benefit Seen in Nonobstructive HCM

A multicenter phase 3 trial has associated a cardiac myosin inhibitor with meaningful clinical benefit in nonobstructive HCM, for which there has been no effective therapies.

Tailored Approach Shortens Endocarditis Therapy

Tailored antibiotic therapy for infective endocarditis was associated with a significant reduction in treatment duration, according to an open-label multicenter trial.

Todays Updates

Faster 1-Hour MI Rule-Out Is Safe

The 1-hour troponin pathway was safely implemented in a real-world study but did not impact workflow in busy emergency departments.

Edoxaban Falls Short After Intracranial Hemorrhage in AF

Edoxaban reduced ischemic stroke after intracranial hemorrhage in patients with AF, but excess hemorrhagic stroke and major bleeding offset the benefit.

Drug Benefit Seen in Nonobstructive HCM

A multicenter phase 3 trial has associated a cardiac myosin inhibitor with meaningful clinical benefit in nonobstructive HCM, for which there has been no effective therapies.

Tailored Approach Shortens Endocarditis Therapy

Tailored antibiotic therapy for infective endocarditis was associated with a significant reduction in treatment duration, according to an open-label multicenter trial.

Latest News

Australia on Sunday confirmed its first case of H5N1 bird flu in a mammal, with the deadly virus ⁠found in a long-nosed fur seal in South Australia state.

Nerandomilast is associated with reduced mortality risk in patients with pulmonary fibrosis, a pooled analysis of two trials shows.

Mastering the HER2 Spectrum for Individualized Management of Advanced/Metastatic NSCLC

Expert Insights on the Next Wave of IO Combinations in mNSCLC

Treating Advanced Disease With Bispecific ADCs: Mechanisms of Action and Therapeutic Rationale for Bispecific ADCs in Solid Tumors

Health news and commentary gathered by MedPage Today staff

News All Time

Real-World Study Backs Mepolizumab in Rhinosinusitis With Nasal Polyps

— 20% of patients were on their way to remission

Tenax Heart Drug Fails to Improve Walking Results in Study, Shares Plunge

Tenax Therapeutics said on Monday its experimental drug did not significantly improve how far patients could walk compared with ⁠placebo in a late-stage trial for a...

Overheard in Medicine: Pandemic Wounds Reopened

Overhead in Medicine is a Medscape digest that surfaces a few of the week’s top posts from major medical subreddits.

Ivacaftor Boosts Height and Lung Function in Cystic Fibrosis

Children and young adults with cystic fibrosis, especially those with severe CFTR variants, who receive ivacaftor have improved height and lung capacity than peers who do not receive ivacaftor.

Housing Aid Linked to Better NSCLC Survival

Housing assistance was associated with lower mortality among older adults with NSCLC, but the survival advantage was not explained by differences in guideline-concordant treatment.

More Bronchiectasis Patients Benefit From HEMT

Data from the US Bronchiectasis and NTM Research Registry show improvements in cough and exacerbations with highly effective modulator therapy.

Integrating Evolving IO Strategies in Frontline mNSCLC Management

Integrating Evolving IO Strategies in Frontline mNSCLC Management

Case Report: Paradoxical Bronchoconstriction with Short-Acting Beta Agonist

Clinicians perform pulmonary function tests to find the cause

Why Is a Fit Swimmer Breathless and Coughing Up Blood?

Case highlights a little-known, potentially dangerous, often recurrent condition of swimmers

Psychosis and Cannabis Legalization: Where's the Evidence?

As marijuana policy shifts nationwide, researchers are tracking possible link to psychosis

FDA Staff Blindsided by Move Allowing More E-Cigs, Nicotine Pouches Onto Market

It's highly unusual for the FDA to draft new policies without input from the staffers

Chronic Sinus Inflammation Linked to Roadway Gases

Gaseous pollutants from traffic sources add to evidence for particulate-matter harms

Targeted Lung Cancer Drug Aces Confirmatory Trial in Frontline Setting

Upfront treatment options set to expand for NSCLC patients with EGFR exon 20 insertions

Drug Combo for Lung Cancer Beats Pembrolizumab in First-Line Trial

Antibody-drug conjugate plus pembrolizumab superior to pembrolizumab alone in PD-L1 expressors

Upfront Ivonescimab Plus Chemo Bests PD-1 Inhibitor Combo in Advanced NSCLC

HARMONi-6 showed 34% drop in death risk, but trial had an all-Asian population, expert warned

'Immediately Practice-Changing' Lung Cancer Trial in Curative Setting

Substantial EFS improvement with selpercatinib in RET fusion-positive disease

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