Genotype-Guided Dosing Reduces Irinotecan Toxicity

Published Date: 17 Jun 2026

Using UGT1A1 genotype to guide irinotecan dosing curbs severe side effects in patients with impaired metabolism of the drug.

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But the risk of relapse after resection of localized appendiceal adenocarcinoma varies by histologic subtype, with potential implications for risk assessment and adjuvant treatment.

Australia has the highest rate of bowel cancer in the world among patients younger than 50 years, and encouraging more people to screen could be key in tackling this problem.

India is witnessing an unprecedented food safety crackdown, with regulators forcing many restaurants to suspend operations and pushing for front-of-pack warning labels.

A prospective Danish study reveals that radiological primary sclerosing cholangitis affects nearly 10% of patients with newly diagnosed inflammatory bowel disease.

Two Trop-2-directed ADCs now hold overlapping first-line TNBC indications with sharply different toxicity profiles. Here's how PD-L1 status and safety data should guide the choice.

A distinctive pattern of inflammatory proteins in the blood of adults with celiac disease reflects the severity of gut damage and may offer a noninvasive way to monitor disease activity.

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