Sevabertinib Approved for First-Line Mutated NSCLC

Published Date: 11 Sep 2026

The oral HER2 TKI was previously given accelerated approval in the second line for the indication.

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The less-intensive drug combination outperforms standard induction chemotherapy in fit patients with acute myeloid leukemia.

The accelerated approval enables an endocrine therapy switch when the ESR1 resistance mutation is detected, rather than waiting for evidence of disease progression.

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Women with breast cancer show interest in self-injecting their medication.

A modest increase in radiation dose improves progression-free survival over 10 years among men with high-risk prostate cancer — but the overall survival benefits found in a French trial are uncertain.

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