Children with cancer tumors lacking DNA repair may benefit from olaparib combined with ceralasertib.

Published Date: 19 Apr 2023

Pediatric patients with solid tumors exhibiting DNA replication stress and/or DNA repair responded favorably to a combination of the investigational ATR inhibitor ceralasertib and the PARP inhibitor olaparib (Lynparza).

Read Full News

Latest News

A Century of Schizophrenia: One Disorder or Many?

Researchers increasingly suggest that biological diversity within schizophrenia may limit efforts to identify a single defining biomarker.

Psychotropics Linked to Increased BMI, CVD Risk

Psychotropics are associated with increased BMI, and users with a high BMI genetic risk score and an unhealthy lifestyle have triple the risk for CVD, new research shows.

Adjuvant Radiation Boosts High-Risk Bladder Cancer Control

For patients with high-risk muscle-invasive bladder cancer, adjuvant radiotherapy improves disease control without increasing the risk of serious side effects.

Blood Test Flags Mantle Cell Lymphoma Relapse Before PET-CT

Results pinpoint who has the worst prognosis and might benefit from different therapies.

Nonpharmacologics May Reduce Anxiety, Depression in SUD

Neuromodulation, mind-body therapy, and other nonpharmacologic interventions are linked to improved psychiatric symptoms in people with SUD, a meta-analysis shows.

WHO Warns Loosely Regulated Nicotine Pouches Risk Youth Addiction

The World Health Organization on Friday urged governments to do more to control the sale of nicotine pouches, warning ⁠that the highly addictive products were being...

Todays Updates

Multiple Myeloma Patients Have Unequal Access to Treatment

Lack of access to innovative and effective treatments compromises survival outcomes for many patients in Europe with multiple myeloma.

e-Cigarettes and Lung Cancer: Is Harm Reduction Overstated?

A large study links the use of e-cigarettes after smoking cessation to higher lung cancer incidence and mortality than complete nicotine abstinence.

Combination Treatment May Improve Multiple Myeloma Outcomes

Post hoc analysis of the MajesTEC-3 trial shows the efficacy of the teclistamab plus daratumumab combination in hard-to-treat patients with high cytogenetic and functional risk.

Is There a Role for Stimulants in Beating Cancer Fatigue?

Guidelines on treating cancer fatigue offer little enthusiasm for methylphenidate and other stimulants. But a recent meta-analysis suggests the medications deserve a rethink.

Todays Updates

Multiple Myeloma Patients Have Unequal Access to Treatment

Lack of access to innovative and effective treatments compromises survival outcomes for many patients in Europe with multiple myeloma.

e-Cigarettes and Lung Cancer: Is Harm Reduction Overstated?

A large study links the use of e-cigarettes after smoking cessation to higher lung cancer incidence and mortality than complete nicotine abstinence.

Combination Treatment May Improve Multiple Myeloma Outcomes

Post hoc analysis of the MajesTEC-3 trial shows the efficacy of the teclistamab plus daratumumab combination in hard-to-treat patients with high cytogenetic and functional risk.

Is There a Role for Stimulants in Beating Cancer Fatigue?

Guidelines on treating cancer fatigue offer little enthusiasm for methylphenidate and other stimulants. But a recent meta-analysis suggests the medications deserve a rethink.

Latest News

Researchers increasingly suggest that biological diversity within schizophrenia may limit efforts to identify a single defining biomarker.

Psychotropics are associated with increased BMI, and users with a high BMI genetic risk score and an unhealthy lifestyle have triple the risk for CVD, new research shows.

For patients with high-risk muscle-invasive bladder cancer, adjuvant radiotherapy improves disease control without increasing the risk of serious side effects.

Results pinpoint who has the worst prognosis and might benefit from different therapies.

Neuromodulation, mind-body therapy, and other nonpharmacologic interventions are linked to improved psychiatric symptoms in people with SUD, a meta-analysis shows.

The World Health Organization on Friday urged governments to do more to control the sale of nicotine pouches, warning ⁠that the highly addictive products were being...

News All Time

Next-Generation KRAS G12C Inhibitor Shows 'Robust' Efficacy in Advanced Lung Cancer

Responses observed in patients with and without previous exposure to other KRAS G12C inhibitors

CAR-T Trial Raises Prospect of Preventing Myeloma in High-Risk Group

All 20 smoldering myeloma patients had deep responses after one-time infusion

More Positive Survival Data in Lung Cancer With Perioperative Therapy

High rate of tumor DNA clearance with chemoimmunotherapy portends improved EFS, possibly OS

Study Linking Fruits, Veggies to Lung Cancer Raises Eyebrows

Association by way of pesticide exposure proposed, but outside experts not so sure

SCOTUS Grapples With Multibillion-Dollar Lawsuits Over Roundup Cancer Claims

Several justices seemed sympathetic to Monsanto's argument that it can't be sued under state law

Rectal Cancer 'Crisis'; Smells Like Cancer; Flushing Away Clues to Colon Cancer

News, features, and commentary about cancer-related issues

Lung Cancer Screening Rates in Eligible Adults Remain Low, Uneven

However, rates were improved from previous survey results

FDA Says First 'Real-Time' Clinical Trial Is Underway

Two sponsors are on board, with a larger pilot program planned later this year

Novel Mimetic Bispecific Antibody Superior to Standard Care in Hemophilia A

Mim8 prophylaxis significantly reduced bleeding events in patients with or without inhibitors

High Rate of Surgical Success in Complex NSCLC With Neoadjuvant Chemoimmunotherapy

Three-fourths of patients had cancer-free mediastinal lymph nodes, clear surgical margins in 93%

Pooled Cord Blood Transplants Achieve Near-Perfect Results in Early Trial

Disease-free survival of 96% with no severe GVHD in acute leukemia, other blood cancers

FDA Panel Endorses Capivasertib Use in Prostate Cancer

Agency staff expressed uncertainty over whether PFS benefit was "clinically meaningful"

Paging Dr. AI; Myth Busting in Cancer; Oncologists Shine in Malpractice Survey

News, features, and commentary about cancer-related issues

J. Craig Venter, Who Won the Race to Sequence the Human Genome, Dies at 79

His death followed a hospitalization for cancer treatment side effects

I Was Told I Had 6 Months to Live. That Was 20 Years Ago.

Here's what two brain surgeries taught me about public health and care access

Woman Loses 6-Year Battle With Mouth Tumor

Rare ameloblastoma rapidly recurs and metastasizes despite numerous radical excisions

Recommended News For You

Telisotuzumab vedotin shows durable response in some Asian patients with nonsquamous NSCLC

Depression risk higher among long-term breast cancer survivors than women without breast cancer history

Higher levels of HIF2α found to slow down aggressive childhood cancer

Children with cancer tumors lacking DNA repair may benefit from olaparib combined with ceralasertib.

New analysis helps discern benign from malignant thyroid growths

Lesser-known lobular breast cancer on the rise in U.S. women

Childhood brain tumors develop early in highly specialized nerve cells, research reveals

Recommended Articles For You

Role of Type I Interferons and KDM1B in Driving Cancer Stemness and Therapeutic Evasion 

Everything You Need To Know About Melanoma Choroid: Causes, Symptoms, and Treatment 

Matrix Metalloproteinases in Stroke: Broad vs. Selective Inhibition Strategies 

Antibody-Drug Conjugates and the Dawn of Targeted Cancer Therapy in 2025 

Whats more on Hidoc Dr.

Medical Updates
KOL Videos
Surveys
Events

Daily news to keep you up to date

Gain valuable insights with our in-depth KOL Video discussions

Participate and win cash vouchers

Get updates on the latest events happening around the world
Featured News
Featured Articles
Featured Events
Featured KOL Videos

1.

Five-year survival in patients with unresectable hepatocellular carcinoma sets milestone

2.

Survey: Record Numbers of US Adults Report Depression.

3.

Increased Exercise May Lower the Risk of Prostate Cancer.

4.

Integrating MRD in Myeloma: Guidance for Therapy Escalation and De-escalation

5.

Adding Lenvatinib to Pembro Ups PFS in Head and Neck Cancer

1.

Oncolytic Vaccinia Virus Immunotherapy: A New Frontier in GI Cancer Treatment

2.

A Review of Cancer Treatment Evolution Towards Stem Cells and Gene Therapy

3.

The Technological Revolution in Precision Oncology and Tumor Microenvironment Therapy

4.

Priming Agents: A Novel Approach to Enhancing Cell-Free DNA Detection in Liquid Biopsies

5.

HPV-Related Cervical Cancer: Advances in Screening, Preventiofn & Treatment

1.

Asian Symposium on Advancement in Hematology and Oncology

2.

Asian Symposium on Advancement in Hematology and Oncology

3.

International Cancer Conference

4.

Asian Symposium on Advancement in Hematology and Oncology

5.

International Lung Cancer Congress®

1.

Current Scenario of Cancer- The Incidence of Cancer in Men

2.

Benefits of Treatment with CDK4/6 Inhibitors in HR+/HER2- aBC in Clinical Trials and the Real World

3.

Revolutionizing Treatment of ALK Rearranged NSCLC with Lorlatinib - Part I

4.

Virtual Case Study on Deep Vein Thrombosis (DVT) - An Initiative by Hidoc Dr.

5.

A Continuation to The Evolving Landscape of First-Line Treatment for Urothelial Carcinoma

Fastest Growing Medical Platform for Doctors

Address :
Hidoc Dr. Inc. | Delaware C Corp | 1309 Coffeen Ave. Suite 1200, Sheridan WY, 82801

Phone :
+1-415-463-3094

Email :
anishagadia@hidoc.co

Quick Links

Drug DatabaseDrug InteractionDiseases Database
KOL VideosKnowledge HubQuizzes
Medical UpdatesEventsAbout Us

© Copyright 2026 Hidoc Dr. Inc.

Terms & Conditions - LLP | Inc. | Privacy Policy - LLP | Inc. | Account Deactivation
Home
Profile
Login
bot