Phase 3 Eplontersen Trial Results Disappoint

Published Date: 30 Aug 2026

Despite a major reduction in transthyretin amyloid deposits, eplontersen, a drug that reduces TTR production, did not reduce events associated with TTR amyloidosis in a phase 3 trial.

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Anticoagulation reduced adverse clinical events in patients with atrial fibrillation at intermediate stroke risk, without an apparent increase in major bleeding.

A heart failure drug combination may not improve exercise capacity in patients with nonobstructive hypertrophic cardiomyopathy but is associated with favorable cardiac structural remodeling.

Lilly's Mounjaro (tirzepatide) is now approved to reduce cardiovascular risk in adults with type 2 diabetes.

Studies suggest that strong recommendations for exercise with GLP-1s are commonly not heeded; possible reasons vary.
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