Gene repression occurs during cellular senescence via the p53-p16/RB-E2F-DREAM complex.

Published Date: 14 Jun 2023

Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes via the p53-p16/RB-E2F-DREAM complex, according to a recently released study in the journal Aging.

Read Full News

Latest News

Molecule that could cause COVID clotting key to new treatments

In a surprising discovery, a "sticky molecule" that occurs naturally in our blood vessels could be both a culprit behind blood clots and organ failure during COVID and long COVID and the key to new treatments to counter COVID-related ...

New potential gene-based treatment for sepsis and lung injury

A new discovery from the lab of YouYang Zhao, Ph.D., from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, opens promising new directions for treatment of life-threatening ...

DNA methylation patterns in newborns point to susceptibility to schizophrenia

Genetic susceptibility to neurodevelopmental conditions such as schizophrenia, autism, and ADHD can be linked, in part, to distinct epigenetic signatures in newborn cord blood. An analysis of nearly 6,000 newborns published ...

CRISPR breakthrough reverses chemotherapy resistance in lung cancer

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach ...

Fertility treatments linked to higher mutations than natural conception in mice

Mice pups conceived with in vitro fertilization (IVF) in the lab have slightly increased rates of DNA errors, or mutations, compared to pups conceived naturally, a new study on artificial reproductive technologies suggests.

A time-sensitive genetic switch for sex-specific features of developing neurons

Researchers have identified that the precisely timed transcription of two genes named grim and reaper is responsible for the targeted death of neurons within the developing nervous system of female flies. This group of neurons ...

Todays Updates

Hyponatremia Risk Varies Among Second-Gen Antipsychotics

Aripiprazole is associated with a lower risk for hyponatremia compared with olanzapine in patients treated with second-generation antipsychotics, a new cohort study shows.

HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

Researchers evaluate changes in post-transplantation outcomes among patients with relapsed or refractory Hodgkin lymphoma from 2010 to 2022.

How Much of a Cancer Drug Is Too Much?

In a recent KFF survey, 43% of US adults said they had skipped their medication in the past year because of cost.

Todays Updates

Hyponatremia Risk Varies Among Second-Gen Antipsychotics

Aripiprazole is associated with a lower risk for hyponatremia compared with olanzapine in patients treated with second-generation antipsychotics, a new cohort study shows.

HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

Researchers evaluate changes in post-transplantation outcomes among patients with relapsed or refractory Hodgkin lymphoma from 2010 to 2022.

How Much of a Cancer Drug Is Too Much?

In a recent KFF survey, 43% of US adults said they had skipped their medication in the past year because of cost.

Latest News

In a surprising discovery, a "sticky molecule" that occurs naturally in our blood vessels could be both a culprit behind blood clots and organ failure during COVID and long COVID and the key to new treatments to counter COVID-related ...

A new discovery from the lab of YouYang Zhao, Ph.D., from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, opens promising new directions for treatment of life-threatening ...

Genetic susceptibility to neurodevelopmental conditions such as schizophrenia, autism, and ADHD can be linked, in part, to distinct epigenetic signatures in newborn cord blood. An analysis of nearly 6,000 newborns published ...

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach ...

Mice pups conceived with in vitro fertilization (IVF) in the lab have slightly increased rates of DNA errors, or mutations, compared to pups conceived naturally, a new study on artificial reproductive technologies suggests.

Researchers have identified that the precisely timed transcription of two genes named grim and reaper is responsible for the targeted death of neurons within the developing nervous system of female flies. This group of neurons ...

News All Time

Surprising blood stem cell diversification revealed in humans

Every second, millions of blood cells are produced in the human body, and about 90% of the cells replaced daily are blood cells. These include red blood cells essential for oxygen transport, platelets for blood clotting, ...

Q&A: Research offers hope for new autoimmune treatments

Alec Whited ('25 MS, Biology) is helping uncover how cells remove waste, a process that could lead to better treatments for autoimmune diseases and improved wound healing.

Tracking RNA levels reveals new clues in triple-negative breast cancer progression

When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer's development or ...

New clinical practice resource on managing RAD51C, RAD51D, and BRIP1 variants released

The American College of Medical Genetics and Genomics (ACMG) has published a new clinical practice resource, "Management of Individuals with Heterozygous Germline Pathogenic Variants in RAD51C, RAD51D, and BRIP1: A clinical ...

Should kids be screened for high cholesterol genes? Study weighs costs and benefits

In the United States, 1 in every 250 people has inherited a genetic variant that leads to dangerously high cholesterol levels from birth.

James Watson helped crack DNA's code, sparking medical advances and ethical debates

On a foggy Saturday morning in 1953, a tall, skinny 24-year-old man fiddled with shapes he had cut out of cardboard. They represented fragments of a DNA molecule, and young James Watson was trying to figure how they fit together ...

Breast cancer relapse: Key cellular resistance mechanism discovered

Triple-negative breast cancer is one of the most aggressive and difficult cancers to treat. It can initially respond well to therapeutic combinations of chemotherapy, but a tiny minority of tumor cells may manage to tolerate ...

Genetically altered hair cells show how inner ear structures are organized

Northwestern Medicine scientists have uncovered how a specific type of cell in the inner ear plays a commanding role in shaping the cellular landscape of the organ responsible for hearing, according to a study published in ...

Key histone variant may explain some forms of infertility

An epigenetic factor that is essential for producing mature egg cells in mice has been identified by RIKEN researchers for the first time. This discovery could aid research into cases of infertility caused by immature eggs.

Hundreds of genes act differently in the brains of men and women

Differences between men and women in intelligence and behavior have been proposed and disputed for decades.

CRISPR screen identifies new regulator of androgen receptor in prostate cancer

A poorly characterized protein, historically thought to be a chaperon or enzyme, may actually be a key player in prostate cancer. In a systematic CRISPR screen, scientists from Arc Institute, UCSF, and the Fred Hutchinson ...

Study identifies key genes linked to aggressive prostate cancer in people of African descent

New prostate cancer research from an international team led by the Center for Genetic Epidemiology at the Keck School of Medicine of USC has yielded discoveries that could improve screening and treatment for patients of African ...

Experimental drug blocks key protein to trigger cancer cell self-destruction in lung tumors

NYU Langone Health researchers found that a type of cell death caused by a buildup of highly reactive molecules suppresses lung tumor growth.

Bowel cancer's 'Big bang': How a crucial moment determines future growth

Like the astronomical explosion that kickstarted the universe, bowel cancer has a "Big Bang" moment which determines how it will grow, according to new research.

DNA discovery could help identify mothers at risk of pre-eclampsia

The human genome is riddled with relics of viral infections—bits of DNA from viruses that have been inserted in human DNA over millions of years and never left. Most are silent but some have taken on functional roles, particularly ...

Hidden nuclear droplets link multiple leukemias and reveal a new therapeutic target

A hidden structure inside the cell is rewriting how scientists understand leukemia. Beneath the microscope, what looked like disorder turned out to follow a simple physical rule—one that connects several major mutations ...

Recommended News For You

Mobile prostate cancer screening clinic can ID the disease in disadvantaged men

A three-quarters reduction in the risk of prostate cancer is associated with an annual increase in cardiorespiratory fitness of more than three percent.

Vepdegestrant Earns FDA Nod for ESR1-Mutated Breast Cancer

New study elucidates obesity's role in fueling breast cancer progression

Improved end-of-life conversations for cancer patients are identified by a new study.

Adaptive SABR-Used Hypofractionated Chemoradiation Showed Good Results in NSCLC.

Datopotamab Deruxtecan Earns New Breast Cancer Indication

Recommended Articles For You

Cracking the Code of Subdural Hematomas: Modern Strategies for Optimal Care 

Stomach Cancer: Uncovering the Subtle Signs and Symptoms 

Transformative Approaches in Hematology for Healthcare Excellence 

Cancer Stem Cells: The Seeds of Tumorigenesis and Recurrence 

Whats more on Hidoc Dr.

Medical Updates
KOL Videos
Surveys
Events

Daily news to keep you up to date

Gain valuable insights with our in-depth KOL Video discussions

Participate and win cash vouchers

Get updates on the latest events happening around the world
Featured News
Featured Articles
Featured Events
Featured KOL Videos

1.

Aspirin Fails to Boost Survival in Colorectal Cancer Trial

2.

Do Anatomy Atlases Reflect Social Inequalities?

3.

A higher risk of chemotherapy-induced peripheral neuropathy is associated with a deficiency in vitamin D prior to treatment.

4.

Some triple negative breast cancers might be avoided by longer breastfeeding

5.

Quizartinib Benefit in AML Limited to FLT3-Mutated Subgroup

1.

Innovative Intraoperative Therapies in Neurosurgical Oncology: Advancing Precision and Outcomes

2.

Metabolic Competition Within the Tumor Ecosystem: Mechanisms, Clinical Relevance, and Therapeutic Advances

3.

Ferroptosis-Modulating Nanocarriers for Solid Tumor Therapy

4.

Unlocking the Mystery of Glanzmann Thrombasthenia: A New Hope for Patients

5.

KEYNOTE-826: Optimizing Outcomes in Persistent, Recurrent, or Metastatic Cervical Cancer

1.

Asian Symposium on Advancement in Hematology and Oncology (ASAHO)

2.

International Cancer Conference

3.

Asian Symposium on Advancement in Hematology and Oncology (ASAHO)

4.

Asian Symposium on Advancement in Hematology and Oncology

5.

Asian Symposium on Advancement in Hematology and Oncology

1.

Clinical Excellence in Hematology

2.

Navigating the Complexities of Ph Negative ALL - Part I

3.

Revolutionizing Treatment of ALK Rearranged NSCLC with Lorlatinib - Part VII

4.

Cost Burden/ Burden of Hospitalization For R/R ALL Patients

5.

Understanding the causes of anemia in adults beyond nutritional deficiencies

Fastest Growing Medical Platform for Doctors

Address :
Hidoc Dr. Inc. | Delaware C Corp | 1309 Coffeen Ave. Suite 1200, Sheridan WY, 82801

Phone :
+1-415-463-3094

Email :
anishagadia@hidoc.co

Quick Links

Drug DatabaseDrug InteractionDiseases Database
KOL VideosKnowledge HubQuizzes
Medical UpdatesEventsAbout Us

© Copyright 2026 Hidoc Dr. Inc.

Terms & Conditions - LLP | Inc. | Privacy Policy - LLP | Inc. | Account Deactivation
Home
Profile
Login
bot