FDA panel backs Pfizer's RSV vaccine for US adults

Published Date: 02 Mar 2023

In a tough vote, advisers to the US Food and Drug Administration (FDA) on Tuesday approved the RSV vaccine for Americans over 60.

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Uraemic Toxins Tied to Septic AKI Severity, Not Mortality

Higher serum levels of most uraemic toxins are associated with the severity of AKI during septic shock, but toxin trajectories are not independently linked to 28-day mortality, a French study finds.

T1D Tied to Early Fracture Risk, Worse With Kidney Disease

Patients with T1D face a higher risk for any fractures, major osteoporotic fractures, and hip fractures than control individuals without diabetes; the risk increases as DKD becomes more severe.

Genes and Environment Shape Childhood Obesity Risk

At ICO 2026, researchers highlighted the need to look beyond lifestyle alone when assessing childhood obesity risk and future metabolic complications.

Lipedema: A Multidisciplinary and Surgical Approach to Care

Speakers at ICO 2026 highlighted the need for earlier recognition, uniform diagnostic criteria, and individualized care that can include lymphatic support, metabolic management, and surgery.

Early Microbiota Therapy Best in Treating Recurrent C diff

Initiating fecal microbiota restoration therapy after the first recurrence of C difficile infection is more cost-effective than delaying it until second recurrence.

Beta Blockers Show More Benefits in Cirrhosis

Nonselective beta-blockers are linked to a lower risk for death in patients with viral hepatitis-related cirrhosis after hospitalization for nonbleeding decompensation events.

Todays Updates

Jazz Seeks Second-Line Lurbinectedin SCLC Withdrawal

The planned label change follows failure of lurbinectedin to improve overall survival in the phase 3 postmarketing trial; the first-line maintenance indication remains unaffected.

Todays Updates

Jazz Seeks Second-Line Lurbinectedin SCLC Withdrawal

The planned label change follows failure of lurbinectedin to improve overall survival in the phase 3 postmarketing trial; the first-line maintenance indication remains unaffected.

Latest News

Higher serum levels of most uraemic toxins are associated with the severity of AKI during septic shock, but toxin trajectories are not independently linked to 28-day mortality, a French study finds.

Patients with T1D face a higher risk for any fractures, major osteoporotic fractures, and hip fractures than control individuals without diabetes; the risk increases as DKD becomes more severe.

At ICO 2026, researchers highlighted the need to look beyond lifestyle alone when assessing childhood obesity risk and future metabolic complications.

Speakers at ICO 2026 highlighted the need for earlier recognition, uniform diagnostic criteria, and individualized care that can include lymphatic support, metabolic management, and surgery.

Initiating fecal microbiota restoration therapy after the first recurrence of C difficile infection is more cost-effective than delaying it until second recurrence.

Nonselective beta-blockers are linked to a lower risk for death in patients with viral hepatitis-related cirrhosis after hospitalization for nonbleeding decompensation events.

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Multilevel Biopsies Boost Pediatric EoE Diagnosis Accuracy

Normal-appearing esophageal mucosa frequently harbors eosinophilic infiltration in children with eosinophilic esophagitis, and biologic therapy shows promise for complete histologic remission.

Thymectomy Not Linked to Increased Cancer Risk

A matched cohort study challenges prior concerns about thymus removal in adults, finding no excess mortality or malignancy over a decade — though outcomes varied by surgical indication.

Becton Dickinson Issues Recall on Certain Lots Of Needle Sets Used for Emergency IV Access

Becton Dickinson said on Friday it is issuing a recall on certain lots of medical needle sets in the ⁠U.S. after users reported difficulty in removing a part of the device...

Pediatric Critical Care Remains Rare in Most EDs

Most EDs rarely treat children with critical illness, and many critical illness encounters at low-volume EDs cannot be easily diverted to nearby high-volume centers, a study finds.

No Benefit From Corticosteroids in Diabetic Preterm Birth

Women with diabetes who receive antenatal corticosteroids before late preterm delivery show no improvement in maternal or neonatal outcomes compared with those who do not receive the treatment.

Can Cyclospora Diet Satire Mislead Vulnerable People?

While many social media users poke fun at the idea of contracting cyclosporiasis as a weight-loss tool, experts warn that some may take the ‘fad’ seriously.

Patients Experiencing Homelessness Face Delayed Discharge

Patients experiencing homelessness are more likely to remain in the hospital after their medical condition has been treated than those with stable housing.

High-Dose Steroids May Aid Recovery in Kids With Pneumonia

High-dose methylprednisolone therapy in children with severe Mycoplasma pneumoniae pneumonia (SMPP) is associated with better recovery and pulmonary function compared with conventional dosing.

Menopause, Obesity, and the Push to Prevent Comorbidities

Speakers at ICO 2026 urge early, tailored treatment to address weight gain, body composition changes, and cardiometabolic risk during menopause.

Peanut Immunotherapy Shows Lasting Benefits at 3 Years

Three years after stopping probiotic peanut or peanut oral immunotherapy, people in remission have fewer reactions and greater QOL gains than those with desensitization without remission.

Sjögren's Disease Tied to Increased Infection Risk

Sjögren's disease is linked to higher rates of bacterial, fungal, and viral infections than matched control individuals with sicca symptoms or other autoimmune diseases.

Two Antibodies May Provide Additional Info on RA Progression

Patients with very early rheumatoid arthritis show two isotypes of anti-carbamylated fibrinogen antibodies that follow different dynamics and may provide additional information on disease progression.

Pneumonia Exposes Hidden Immune Deficiencies

A Swedish study finds that assessing M protein and immunoglobulin levels in adults with invasive pneumococcal disease can uncover previously undiagnosed blood cancers or immune deficiencies.

Congo's Ebola Outbreak Is 2nd-Largest on Record, Latest Data

Democratic Republic of Congo's fast-spreading Ebola outbreak is now the world's second-largest on record, as transmission continues ⁠to outpace efforts to contain the epidemic.

COVID ICU Patients May Face Reduced Exercise Capacity

Patients requiring intensive care for COVID pneumonia have reduced exercise capacity and more frequent restrictive pulmonary function patterns in the early post-COVID period.

Jul 31 2026 This Week in Cardiology

Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD, discusses in this week’s podcast.