Clinical significance of perineural invasion by prostate cancer

Published Date: 08 Mar 2023

This study examines the clinical impact of unilateral perineural invasion in prostate cancer. How does unilaterality affect long-term oncology outcomes?

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Drs Kathy Miller and Sunil Badve discuss how HER2 testing has evolved over time as the need for that clinical testing has shifted, including assay limits, biology, and clinical impact.

Heart Failure with Improved ejection fraction is characterized by previously reduced left ventricular ejection fraction (≤40%) that subsequently improves to >40%. This review highlight existing clinical gaps and proposes future research directions to refine risk stratification and therapeutic approaches for this evolving HF population.

What will the next decade bring for myelofibrosis care? Drs Jain and Pemmaraju explore futuristic therapies, earlier interventions, and smarter diagnostics.

Drs Kaniksha Desai and Iram Hussain discuss the use of radiofrequency ablation for the treatment of hyperthyroidism.

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer.

The controversial KETO-CTA study, tough decisions in subclinical AF, and another potentially huge benefit for GLP-1 agonist drugs are discussed by John Mandrola, MD, in this week’s podcast.

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Spinal Muscular Atrophy: 5 Things to Know

SMA ranges from mild with slow progression to severe with loss of life in childhood. These five things to know are crucial to understanding the types, causes, diagnosis, and latest treatments.

Managing Familial Hypercholesterolemia in Primary Care

Familial hypercholesterolemia is often diagnosed late, and patients with the condition are significantly undertreated.

S2 Episode 1: Hormonal Therapy Updates in Metastatic Endometrial Cancer

Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss hormonal therapy updates and different ways to target and treat ER+ metastatic endometrial cancer.

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Drs Ursula A. Matulonis and Eloise Chapman-Davis discuss overcoming health disparities in endometrial cancer and increasing clinical trial enrollment of Black women.

IgA Nephropathy: 5 Differential Diagnoses to Know

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Arnold B. Alper, MD, discusses the IgA nephropathy differential diagnosis.

SABCS 2024: New Treatment Options in HR+/HER2- Breast Cancer

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Key Updates in Early Breast Cancer From SABCS 2024

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More Than Hives: Discussing Chronic Spontaneous Urticaria

Dermatologists discuss common roadblocks in communicating with patients with chronic spontaneous urticaria, who often search for a cause they can fix for a condition lacking in community resources.

Cardiac Myosin Inhibitors: Is the Emperor Wearing Any Clothes?

A commentary on the need for better trials and long-term data for the myosin inhibitors aficamten and mavacamten in obstructive hypertrophic cardiomyopathy.

New Directions in Anemia and Related Disorders From ASH 2024

Strategies to reduce disease burden in alpha- or beta-thalassemia, sickle cell disease, and polycythemia vera, and insights into anemia in IBD, are among anemia highlights from ASH 2024.

Episode 6: HER2-Ultra-Low Breast Cancer

Drs Kathy Miller and Francisco J. Esteva discuss testing and therapeutic options for the new classification of HER2-ultra-low breast cancer.

Growth Hormone and the Thyroid Gland: A Complex Relationship

Drs Kaniksha Desai and Laurence Katznelson discuss the complex relationship between growth hormone and the thyroid gland.

ACR 2024: Key Insights on Updated Lupus Nephritis Guidelines

Dr Bella Mehta reviews new guidance on frequent monitoring, triple therapy, early biopsy, and reduced steroids for better outcomes.

Episode 5: Sequencing of ADCs for Metastatic HER2-Low Disease

Kathy D. Miller, MD, and Stephanie L. Graff, MD, discuss sequencing of ADCs for metastatic HER2-low breast cancer including sequencing, toxicities, and clinical trials.

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Glomerular disease highlights from ASN 2024 include data on atacicept benefits in IgA nephropathy, protein reduction from pegcetacoplan, and a possible new therapy for membranous nephropathy.

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