Clinical significance of perineural invasion by prostate cancer

Published Date: 08 Mar 2023

This study examines the clinical impact of unilateral perineural invasion in prostate cancer. How does unilaterality affect long-term oncology outcomes?

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Mar 20 2026 This Week in Cardiology

Listener feedback, the huge CLOSURE-AF trial of LAAC vs best medical therapy, previews of CHAMPION AF, and the controversial ACC/AHA lipid treatment guidelines are the topics John Mandrola, MD, discusses in this week's podcast.

Insights in Renal Cell Carcinoma From ASCO GU 2026

Clinically significant developments in RCC presented at ASCO GU, including insights into the growing importance of HIF-2α inhibition, are discussed by Dr Brian Rini of Vanderbilt University.

Quantifying Cardiac Amyloid Burden

A standardized metric to quantify amyloid burden has yet to be established. Could extracellular volume assessments help track ATTR-CM disease status.

A 2-Year-Old Girl With a Single Pink “Bump” on Her Abdomen

The bump had been present for about 3 months. The patient’s mother said there had been no bleeding, tenderness, color change, rapid growth, or preceding trauma.

Rules for Thee, Not for Me: Neuroscience & Double Standards

With respect to the so-called ‘moral compass’, humans invariably judge others more harshly than they judge themselves.

ACC 2026: Anticipating New Data in Amyloid and ATTR-CM

Dr Kevin M. Alexander prepares for updates on amyloid research, real-world evidence, and imaging biomarkers.

Todays Updates

Therapeutic Drug Monitoring Widely Variable in Ped Rheum

In a survey, pediatric rheumatologists cite a lack of training, lack of data, turnaround time, and lab timing as barriers to broader use.

Treat the Patient, Not the Biomarker: The ctDNA Dilemma

Professor David Kerr warns against 'treating the marker' in CRC. Should rising ctDNA trigger chemo without radiologic proof?

Stress Doesn’t Cause Cancer

The mistaken belief that stress can cause cancer leads many affected individuals to blame themselves for their cancer.

IV Ferumoxytol Beats Oral Iron for Pregnancy Anemia

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PRP Injection Improves Female Sexual Function

Platelet-rich plasma injections into the anterior vaginal wall enhance sexual function in premenopausal women.

FDA Seeks New Warning for Certain Parkinson's Drugs

The FDA said on Friday it has notified manufacturers of certain Parkinson's ⁠disease treatments to update their prescribing information with a...

Is ‘Spring Fatigue’ Real? Sleep Study Questions It

In a nine-wave online survey of 418 adults over 18 months, researchers find fatigue levels do not fluctuate seasonally — only everyday activity fatigue falls as days lengthen.

Todays Updates

Therapeutic Drug Monitoring Widely Variable in Ped Rheum

In a survey, pediatric rheumatologists cite a lack of training, lack of data, turnaround time, and lab timing as barriers to broader use.

Treat the Patient, Not the Biomarker: The ctDNA Dilemma

Professor David Kerr warns against 'treating the marker' in CRC. Should rising ctDNA trigger chemo without radiologic proof?

Stress Doesn’t Cause Cancer

The mistaken belief that stress can cause cancer leads many affected individuals to blame themselves for their cancer.

IV Ferumoxytol Beats Oral Iron for Pregnancy Anemia

Intravenous ferumoxytol shows higher efficacy than oral iron in the treatment of anemia in pregnant women, improving hemoglobin at delivery and achieving better anemia resolution.

PRP Injection Improves Female Sexual Function

Platelet-rich plasma injections into the anterior vaginal wall enhance sexual function in premenopausal women.

FDA Seeks New Warning for Certain Parkinson's Drugs

The FDA said on Friday it has notified manufacturers of certain Parkinson's ⁠disease treatments to update their prescribing information with a...

Is ‘Spring Fatigue’ Real? Sleep Study Questions It

In a nine-wave online survey of 418 adults over 18 months, researchers find fatigue levels do not fluctuate seasonally — only everyday activity fatigue falls as days lengthen.

Latest News

Listener feedback, the huge CLOSURE-AF trial of LAAC vs best medical therapy, previews of CHAMPION AF, and the controversial ACC/AHA lipid treatment guidelines are the topics John Mandrola, MD, discusses in this week's podcast.

Clinically significant developments in RCC presented at ASCO GU, including insights into the growing importance of HIF-2α inhibition, are discussed by Dr Brian Rini of Vanderbilt University.

A standardized metric to quantify amyloid burden has yet to be established. Could extracellular volume assessments help track ATTR-CM disease status.

The bump had been present for about 3 months. The patient’s mother said there had been no bleeding, tenderness, color change, rapid growth, or preceding trauma.

With respect to the so-called ‘moral compass’, humans invariably judge others more harshly than they judge themselves.

Dr Kevin M. Alexander prepares for updates on amyloid research, real-world evidence, and imaging biomarkers.

News All Time

Why Med Students Think They’re Dying (When They’re Not)

Studying disease amid the stress of medical school can make every headache a tumor and every muscle twitch ALS. Welcome to ‘med school syndrome.’ Try not to panic.

When the Doctor Needs a Checkup

Researchers have documented a gradual decline in physicians’ cognitive abilities starting in their mid-sixties.

Just 1 in 8 Nurses Would Recommend the Profession

Only 12% of UK nurses would recommend their profession — despite most reporting job satisfaction — as harassment, discrimination, and workload pressures take a toll.

Preventing Burnout in Clinical Practice

Perfectionism, empathy, and blurred boundaries — together with workload, staff shortages, and constant connectivity — create a high risk for stress for clinicians.

Death Rates Higher With ‘Alternative’ Cancer Therapies

Complementary and alternative medicine is more popular than ever, but does it help or hinder conventional cancer treatment?

S2 Episode 5: HER2 Low Testing in the ADC Era

Drs Kathy Miller and Sunil Badve discuss how HER2 testing has evolved over time as the need for that clinical testing has shifted, including assay limits, biology, and clinical impact.

HF With Improved Ejection Fraction

Heart Failure with Improved ejection fraction is characterized by previously reduced left ventricular ejection fraction (≤40%) that subsequently improves to >40%. This review highlight existing clinical gaps and proposes future research directions to refine risk stratification and therapeutic approaches for this evolving HF population.

S2 Episode 6: A Futuristic Vision for Treating Myelofibrosis

What will the next decade bring for myelofibrosis care? Drs Jain and Pemmaraju explore futuristic therapies, earlier interventions, and smarter diagnostics.

Radiofrequency Ablation: A First-Line Treatment Option

Drs Kaniksha Desai and Iram Hussain discuss the use of radiofrequency ablation for the treatment of hyperthyroidism.

S2 Episode 5: DNA Repair and Replication Stress in Endometrial Cancer

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer.

May 09 2025 This Week in Cardiology

The controversial KETO-CTA study, tough decisions in subclinical AF, and another potentially huge benefit for GLP-1 agonist drugs are discussed by John Mandrola, MD, in this week’s podcast.

Should All Newborns Be Screened for Congenital Hypothyroidism?

Drs Kaniksha Desai and Larry Fox discuss congenital hypothyroidism, including when to test and how to treat it.

S2 Episode 4: Immunotherapy Insights and Research in Endometrial Cancer

Drs Ursula A. Matulonis and Gini F. Fleming discuss the state of endometrial cancer, the role of immunotherapy, and priorities for research in this field.

USCAP 2025

Read clinically focused news coverage of key developments from USCAP 2025

S3 Episode 3: The 2025 updates of the American Diabetes Association

Drs Carol H. Wysham and Rozalina G. McCoy discuss the 2025 updates of the American Diabetes Association, including comorbidities, dental care, sexual dysfunction, and CGM use.

Episode 2: New Guidelines and the Lupus Nephritis Kidney Conundrum

Join Drs Maureen McMahon and Brad Rovin as they discuss the KDIGO, ACR and EULAR guidelines as they relate to lupus nephritis.

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