Despite efforts for improvement, the "State of the Air" report reveals concerns.

Published Date: 23 Apr 2023

Despite Improvement Efforts, the "State of the Air" Report Highlights Issues.

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CPAP May Offer Enhanced BP Benefit in Sleep Apnea & Insomnia

Patients with both insomnia and obstructive sleep apnea may represent a clinical phenotype characterized by an enhanced systolic BP-lowering response to continuous positive airway pressure therapy.

Australia Confirms First H5N1 Bird Flu Case in Local Mammal

Australia on Sunday confirmed its first case of H5N1 bird flu in a mammal, with the deadly virus ⁠found in a long-nosed fur seal in South Australia state.

Nerandomilast Lowers Mortality Risk in Pulmonary Fibrosis

Nerandomilast is associated with reduced mortality risk in patients with pulmonary fibrosis, a pooled analysis of two trials shows.

Mastering the HER2 Spectrum for Individualized Management of Advanced/Metastatic NSCLC

Mastering the HER2 Spectrum for Individualized Management of Advanced/Metastatic NSCLC

Expert Insights on the Next Wave of IO Combinations in mNSCLC

Expert Insights on the Next Wave of IO Combinations in mNSCLC

Treating Advanced Disease With Bispecific ADCs: Mechanisms of Action and Therapeutic Rationale for Bispecific ADCs in Solid Tumors

Treating Advanced Disease With Bispecific ADCs: Mechanisms of Action and Therapeutic Rationale for Bispecific ADCs in Solid Tumors

Todays Updates

Bilateral Mastectomy Rises in Young BRCA1/2 Carriers

Among young women with BRCA1/2 mutations and breast cancer, bilateral mastectomy rates increased substantially from 2000 to 2020.

Proteinuria Remission Predicts Outcomes in Pediatric IgAN

Children with IgA nephropathy who achieve sustained proteinuria remission have significantly better long-term kidney function over 5 years than those who do not.

BRCA Mutation Carriers Likely to Have Risk-Reducing Surgery

Researchers conduct a study of about 4000 women with pathogenic variants in at least one of 13 breast cancer susceptibility genes to see their utilization of cancer risk-reducing procedures.

Once-Nightly Eye Drop Aids Dim-Light Vision

In patients who face difficulty seeing in low light, a once-nightly eye drop significantly improves night vision and reduces glare, halos, and starbursts, a phase 3 trial shows.

Ketamine Infusions Shows Benefit in Bipolar Depression

Adjunctive serial IV ketamine infusions significantly reduced depressive symptoms in TRBD, with no cases of mania, hypomania, or psychosis observed in the randomized trial.

Digital Pillbox Boosts Short-Term Viral Control in Young PWH

A digital pillbox with medication reminders and adherence feedback improves viral suppression in young people with HIV over 6 months, a trial finds.

Distinct Risk Factor Profiles Tied to Endometriosis Subtypes

Various factors such as menstrual history, pain conditions, and immune disorders are distinctly tied to endometriosis lesion types — superficial lesions, ovarian cysts, and deep lesions.

Todays Updates

Bilateral Mastectomy Rises in Young BRCA1/2 Carriers

Among young women with BRCA1/2 mutations and breast cancer, bilateral mastectomy rates increased substantially from 2000 to 2020.

Proteinuria Remission Predicts Outcomes in Pediatric IgAN

Children with IgA nephropathy who achieve sustained proteinuria remission have significantly better long-term kidney function over 5 years than those who do not.

BRCA Mutation Carriers Likely to Have Risk-Reducing Surgery

Researchers conduct a study of about 4000 women with pathogenic variants in at least one of 13 breast cancer susceptibility genes to see their utilization of cancer risk-reducing procedures.

Once-Nightly Eye Drop Aids Dim-Light Vision

In patients who face difficulty seeing in low light, a once-nightly eye drop significantly improves night vision and reduces glare, halos, and starbursts, a phase 3 trial shows.

Ketamine Infusions Shows Benefit in Bipolar Depression

Adjunctive serial IV ketamine infusions significantly reduced depressive symptoms in TRBD, with no cases of mania, hypomania, or psychosis observed in the randomized trial.

Digital Pillbox Boosts Short-Term Viral Control in Young PWH

A digital pillbox with medication reminders and adherence feedback improves viral suppression in young people with HIV over 6 months, a trial finds.

Distinct Risk Factor Profiles Tied to Endometriosis Subtypes

Various factors such as menstrual history, pain conditions, and immune disorders are distinctly tied to endometriosis lesion types — superficial lesions, ovarian cysts, and deep lesions.

Latest News

Patients with both insomnia and obstructive sleep apnea may represent a clinical phenotype characterized by an enhanced systolic BP-lowering response to continuous positive airway pressure therapy.

Australia on Sunday confirmed its first case of H5N1 bird flu in a mammal, with the deadly virus ⁠found in a long-nosed fur seal in South Australia state.

Nerandomilast is associated with reduced mortality risk in patients with pulmonary fibrosis, a pooled analysis of two trials shows.

Mastering the HER2 Spectrum for Individualized Management of Advanced/Metastatic NSCLC

Expert Insights on the Next Wave of IO Combinations in mNSCLC

Treating Advanced Disease With Bispecific ADCs: Mechanisms of Action and Therapeutic Rationale for Bispecific ADCs in Solid Tumors

News All Time

Senators Pan Trump Officials' Demand for Health Data as Condition for Lifesaving Aid

"These new demands set an alarming precedent," Democratic senators noted

Real-World Study Backs Mepolizumab in Rhinosinusitis With Nasal Polyps

— 20% of patients were on their way to remission

Overheard in Medicine: Pandemic Wounds Reopened

Overhead in Medicine is a Medscape digest that surfaces a few of the week’s top posts from major medical subreddits.

Tenax Heart Drug Fails to Improve Walking Results in Study, Shares Plunge

Tenax Therapeutics said on Monday its experimental drug did not significantly improve how far patients could walk compared with ⁠placebo in a late-stage trial for a...

Ivacaftor Boosts Height and Lung Function in Cystic Fibrosis

Children and young adults with cystic fibrosis, especially those with severe CFTR variants, who receive ivacaftor have improved height and lung capacity than peers who do not receive ivacaftor.

Housing Aid Linked to Better NSCLC Survival

Housing assistance was associated with lower mortality among older adults with NSCLC, but the survival advantage was not explained by differences in guideline-concordant treatment.

More Bronchiectasis Patients Benefit From HEMT

Data from the US Bronchiectasis and NTM Research Registry show improvements in cough and exacerbations with highly effective modulator therapy.

Integrating Evolving IO Strategies in Frontline mNSCLC Management

Integrating Evolving IO Strategies in Frontline mNSCLC Management

Case Report: Paradoxical Bronchoconstriction with Short-Acting Beta Agonist

Clinicians perform pulmonary function tests to find the cause
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FDA Staff Blindsided by Move Allowing More E-Cigs, Nicotine Pouches Onto Market

It's highly unusual for the FDA to draft new policies without input from the staffers

Chronic Sinus Inflammation Linked to Roadway Gases

Gaseous pollutants from traffic sources add to evidence for particulate-matter harms

Targeted Lung Cancer Drug Aces Confirmatory Trial in Frontline Setting

Upfront treatment options set to expand for NSCLC patients with EGFR exon 20 insertions

Drug Combo for Lung Cancer Beats Pembrolizumab in First-Line Trial

Antibody-drug conjugate plus pembrolizumab superior to pembrolizumab alone in PD-L1 expressors

Upfront Ivonescimab Plus Chemo Bests PD-1 Inhibitor Combo in Advanced NSCLC

HARMONi-6 showed 34% drop in death risk, but trial had an all-Asian population, expert warned

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