Combination immunotherapy helps overcome melanoma treatment resistance

Published Date: 09 Nov 2025

Early data from a Phase 2 clinical trial show a combination of immunotherapy medications can activate a robust immune response and help overcome treatment resistance in patients with refractory melanoma.

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Best Treatments for BD: Current Evidence, New Online Tool

A ‘living’ evidence review of bipolar disorder treatments has been transformed into a free, continuously updated online tool that helps clinicians and patients weigh efficacy, side effects, and individual preferences.

Add-On Citicoline May Improve Motor Function in PD

Citicoline added to dopaminergic therapy is safe and tied to higher odds of clinically meaningful improvement than placebo in motor function in Parkinson’s, a trial shows.

How Two Brains Can Quickly Be ‘On the Same Wavelength’

Researchers are learning which situations encourage neural synchrony — that increasingly elusive feeling of being ‘in flow’ with others — and how we can benefit.

Up the Ante for Lung Cancer Screening in Women

Rising incidence calls for more recognition of lung cancer risks in nonsmoking women.

As Federal Loan Cap Takes Effect, Medical Schools Step Up

Medical schools are reaching out to inform students and make more funds available after federal help shrinks. Students debate best options.

Brain Age Tied to Dementia Risk in Those With Memory Issues

An automated MRI measure shows that each extra year the brain appears older than chronologic age is linked to increased dementia risk, especially in patients with subjective cognitive concerns.

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Hyponatremia Risk Varies Among Second-Gen Antipsychotics

Aripiprazole is associated with a lower risk for hyponatremia compared with olanzapine in patients treated with second-generation antipsychotics, a new cohort study shows.

HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

Researchers evaluate changes in post-transplantation outcomes among patients with relapsed or refractory Hodgkin lymphoma from 2010 to 2022.

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In a recent KFF survey, 43% of US adults said they had skipped their medication in the past year because of cost.

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Hyponatremia Risk Varies Among Second-Gen Antipsychotics

Aripiprazole is associated with a lower risk for hyponatremia compared with olanzapine in patients treated with second-generation antipsychotics, a new cohort study shows.

HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

Researchers evaluate changes in post-transplantation outcomes among patients with relapsed or refractory Hodgkin lymphoma from 2010 to 2022.

How Much of a Cancer Drug Is Too Much?

In a recent KFF survey, 43% of US adults said they had skipped their medication in the past year because of cost.

Latest News

A ‘living’ evidence review of bipolar disorder treatments has been transformed into a free, continuously updated online tool that helps clinicians and patients weigh efficacy, side effects, and individual preferences.

Citicoline added to dopaminergic therapy is safe and tied to higher odds of clinically meaningful improvement than placebo in motor function in Parkinson’s, a trial shows.

Researchers are learning which situations encourage neural synchrony — that increasingly elusive feeling of being ‘in flow’ with others — and how we can benefit.

Rising incidence calls for more recognition of lung cancer risks in nonsmoking women.

Medical schools are reaching out to inform students and make more funds available after federal help shrinks. Students debate best options.

An automated MRI measure shows that each extra year the brain appears older than chronologic age is linked to increased dementia risk, especially in patients with subjective cognitive concerns.

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THC Safe, Effective for PTSD-Related Nightmares

Dronabinol, a medication containing THC, is linked to fewer nightmares at lower intensity compared to placebo in patients with post-traumatic stress disorder, new data show.

French Hospital Brings Phage Therapy Closer to Clinical Use

A first-in-world public authorization to manufacture GMP therapeutic phages could expand clinical trials, strengthen regulated access, and accelerate evidence-based treatment.

Self-Sampling Can Be Feasible for Respiratory Infections

A Swiss pilot study shows that self-sampling at home is feasible for detecting respiratory infections and supports creating a decentralised household-based cohort for pandemic preparedness.

Bipolar Disorder Linked to Higher Mortality in Older Adults

Bipolar disorder is associated with a 72% increased risk for mortality over 8 years in older adults compared with the general population, a new prospective study shows.

Age and MRI Features Predict MS Odds After Initial Symptoms

Younger age at onset, multifocal symptoms, and specific MRI findings are associated with increased odds of multiple sclerosis diagnosis after a first demyelinating event.

Prostate Surgery Leakage Improves Over 12 Months

About 1 in 5 patients develop urinary incontinence 3 months after thulium fiber laser enucleation of the prostate, with rates decreasing over 12 months.

Nirsevimab Linked to Lower Risk for IPD Hospitalizations

Nirsevimab immunization in children younger than 12 months is linked to a lower risk for hospitalization for invasive pneumococcal disease, a French nationwide analysis shows.

‘Big Beautiful’ Law Tests Rural Hospital Lifeline

A century-old hospital near Michigan’s southern border was one of the nation’s first to convert into a new emergency-focused model Congress created to save rural care.

Romanian Healthcare Workers End Strike Over Pay, Staffing

Romanian healthcare workers ended a nationwide strike on ⁠Friday as the country's caretaker government approved new hires in ⁠short-staffed state hospitals.

Swimming Linked to Reduced Disability in Low Back Pain

Swimming plus education is more effective than education alone in reducing disability in adults with chronic low back pain over 8 weeks, a trial shows.

Preterm Lung Disease: One Drug Testing May Miss Responders

Most children born premature with chronic lung disease have reversible airway obstruction, but bronchodilator responses vary widely, underscoring the need for individualized testing.

Vancomycin Prophylaxis Tied to Lower C difficile Recurrence

In children and young adults with cancer, oral vancomycin prophylaxis during broad-spectrum antibiotic therapy is associated with a lower risk for recurrent Clostridioides difficile infection.

Spousal Dementia Tied to Higher Dementia Risk

Spouses of individuals with dementia have a significantly higher risk of developing dementia, new research shows.

Infections Tied to Increased Risk for Brain Disorders

Hospitalization due to an acute infection, especially infectious encephalitides, is linked to increased risk for psychiatric and neurologic disorders, a new study shows.

Romanian Healthcare Workers Strike Over Wage Bill Needed to Secure EU Funds

Thousands of Romanian doctors, nurses and other health workers went on an indefinite strike ⁠for the first time in a decade on Tuesday, protesting job freezes and a public...

The Restorative Power of ‘Sacred Moments’ in Medicine

Deep human connection can be a potent antidote to burnout. Here’s how to cultivate meaning in an increasingly rushed healthcare system.

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