M1 Variant Lowers APOL1 Kidney Disease Risk

Published Date: 21 Apr 2026

Although APOL1 variants are linked to kidney disease risk, the presence of the M1 genetic variant appears to reduce that risk.

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Among adults with type 1 and type 2 diabetes in Denmark, the incidence of CKD declined from 2016 to 2024 even as its prevalence rose, and mortality remained substantially higher in those with CKD.

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