PARP Inhibitors for Prostate Cancer: 5 Things to Know

Published Date: 31 Jul 2026

PARP inhibitors are reshaping the treatment landscape for metastatic prostate cancer, but who actually benefits, and how do we navigate the toxicity and testing gaps to use them wisely?

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The Future of Oncology Clinical Pathways in VHA

VA oncology Clinical Pathways logged 26,613 entries for 11,835 patients in FY25, standardizing care and paving the way to Oracle Health EHR.

Normal, but Not Optimal: Rethinking Perimenopause

In this roundtable, Drs Rachel Rubin, Makeba Williams, and Anna Cabeca discuss the changing landscape of perimenopause care — and why every clinician should join the conversation.

Inflammation on Imaging May Help Predict Hand OA Progression

Synovitis detected using ultrasonography and MRI is associated with increased odds of structural worsening in thumb base and finger joints in patients with hand osteoarthritis.

Allo-HSCT Shows Long-Term Benefit in Hepatosplenic Lymphoma

Researchers examine the roles of allogeneic and autologous HSCT in patients with hepatosplenic T-cell lymphoma and identify factors linked to survival after transplantation.

Insomnia Diagnoses, Rx Surge in Catalan Primary Care

Insomnia diagnoses and related pharmacologic prescriptions show a rise among adults in Central Catalonia; those with insomnia and polypharmacy are more likely to receive pharmacologic treatment.

Cenobamate May Offer Benefits in Rare Childhood Epilepsy

Cenobamate is linked to sustained seizure control and higher treatment retention rates over 12 months in children with developmental and epileptic encephalopathies.

Todays Updates

Sevabertinib Approved for First-Line Mutated NSCLC

The oral HER2 TKI was previously given accelerated approval in the second line for the indication.

Todays Updates

Sevabertinib Approved for First-Line Mutated NSCLC

The oral HER2 TKI was previously given accelerated approval in the second line for the indication.

Latest News

VA oncology Clinical Pathways logged 26,613 entries for 11,835 patients in FY25, standardizing care and paving the way to Oracle Health EHR.

In this roundtable, Drs Rachel Rubin, Makeba Williams, and Anna Cabeca discuss the changing landscape of perimenopause care — and why every clinician should join the conversation.

Synovitis detected using ultrasonography and MRI is associated with increased odds of structural worsening in thumb base and finger joints in patients with hand osteoarthritis.

Researchers examine the roles of allogeneic and autologous HSCT in patients with hepatosplenic T-cell lymphoma and identify factors linked to survival after transplantation.

Insomnia diagnoses and related pharmacologic prescriptions show a rise among adults in Central Catalonia; those with insomnia and polypharmacy are more likely to receive pharmacologic treatment.

Cenobamate is linked to sustained seizure control and higher treatment retention rates over 12 months in children with developmental and epileptic encephalopathies.

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FDA Approves Stelara for Pediatric Ulcerative Colitis

Ustekinumab, the IL-12/23 inhibitor, is the first non-TNF-targeting monoclonal antibody approved for both pediatric UC and Crohn's disease.

Proteinuria Remission Predicts Outcomes in Pediatric IgAN

Children with IgA nephropathy who achieve sustained proteinuria remission have significantly better long-term kidney function over 5 years than those who do not.

Digital Pillbox Boosts Short-Term Viral Control in Young PWH

A digital pillbox with medication reminders and adherence feedback improves viral suppression in young people with HIV over 6 months, a trial finds.

Ketamine Infusions Shows Benefit in Bipolar Depression

Adjunctive serial IV ketamine infusions significantly reduced depressive symptoms in TRBD, with no cases of mania, hypomania, or psychosis observed in the randomized trial.

Once-Nightly Eye Drop Aids Dim-Light Vision

In patients who face difficulty seeing in low light, a once-nightly eye drop significantly improves night vision and reduces glare, halos, and starbursts, a phase 3 trial shows.

BRCA Mutation Carriers Likely to Have Risk-Reducing Surgery

Researchers conduct a study of about 4000 women with pathogenic variants in at least one of 13 breast cancer susceptibility genes to see their utilization of cancer risk-reducing procedures.

Distinct Risk Factor Profiles Tied to Endometriosis Subtypes

Various factors such as menstrual history, pain conditions, and immune disorders are distinctly tied to endometriosis lesion types — superficial lesions, ovarian cysts, and deep lesions.

The Digital Health Revolution Has a People Problem

As healthcare races to adopt digital technologies, what can health systems do to equip clinicians with the skills to use them safely and effectively?

A Public Utility Model for Primary Care?

As more struggling practices turn to private equity, Dr Kenny Lin asks who benefits — and whether a public utility model offers a workable alternative.

Autonomous Pharmacy Prescribing: The Wrong Rx for Australia

Autonomous pharmacy prescribing may be convenient, but the evidence is thin, and the conflicts are real. For Australian patients, it could be a bitter pill to swallow.

Modified Vitamin A May Slow Rare Vision Disease

A deuterium-enriched vitamin A pill slows the growth of retina-damaging lesions in Stargardt disease by more than 20%, according to a recent clinical trial.

Recombinant Flu Vaccine Cuts Nursing Home Outbreaks

Recombinant quadrivalent influenza vaccine is linked to fewer influenza outbreaks in nursing homes during the 2019-2020 season.

Greater Depression Severity Predicts Higher iCBT Benefits

An individual treatment benefit prediction model reveals that patients with more severe depression receive greater benefits from internet-based cognitive-behavioural therapy.

Avacopan in Vasculitis: Uncommon but Severe Liver Risks

Liver enzyme elevations related to avacopan therapy are uncommon in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, although drug-induced liver injury may occur.

Does Liver Disease Affect Cholangiocarcinoma Outcomes?

Patients diagnosed with cholangiocarcinoma who have preexisting chronic liver disease experience improved survival compared with those who do not have prior chronic liver disease.

Does Pediatric ALL Therapy Work Long-Term in Young Adults?

Researchers evaluate the 10-year outcomes of a pediatric-inspired regimen in adolescents and young adults with Philadelphia chromosome-negative acute lymphoblastic leukemia.