Conventional Wisdom on CGRP in Migraine Challenged

Published Date: 03 Jul 2026

Plasma CGRP levels were lower in adults with migraine vs healthy adults and did not vary by subtype, attack status, or preventive treatment use, questioning use of plasma CGRP as a migraine biomarker.

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Latest News

Functional angiography is linked to a 38% lower risk for the primary outcome over conventional angiography in STEMI patients with multivessel disease.

Large cohort study shows sweet spot at 1-3 g/dL above the WHO threshold.

Children with prosthetic valve endocarditis present at an older age and show lower echocardiographic detection than those with native valve disease; complications and surgery are highly frequent.

Intra-amniotic infection is associated with early-onset neonatal sepsis in pregnancies complicated by preterm prelabor rupture of membranes.

It is nearly 20 years since trials of prasugrel and ticagrelor showed better protection over clopidogrel against MACE for ACS, but superiority of one over the other still remains unresolved.

In perimenopausal and recently postmenopausal women experiencing hot flashes and/or night sweats, initiating hormone therapy is associated with a reduction in the risk for cardiovascular events.

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Response-Guided Therapy Trims Antibiotic Use in Endocarditis

Stopping antibiotics at clinical stabilisation in patients with left-sided endocarditis yields more days off therapy than standard regimens but is linked to a higher rate of relapse, a trial finds.

NICE Expands Drug Access for Young Children With NF1 Tumours

Trial data behind the decision showed durable tumour shrinkage and improved pain outcomes with mirdametinib, now recommended by NICE for children from age 2.

Cardiometabolic Risks Arise Early After Gestational Diabetes

Gestational diabetes is linked to an increased risk for type 2 diabetes and other cardiometabolic conditions within the first few years postpartum.

Cold Weather and Cardiovascular Risk: Does Climate Matter?

A large Brazilian study suggests colder temperatures may increase cardiovascular hospitalizations, while regional climate differences did not appear to change the association.

GLP-1s Tied to Metabolic Benefits in Rheumatology Patients

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Exercise Cuts Arrhythmia Burden by 45% in AF

In the randomized NEXAF trial, a 1-year personalized exercise program reduced atrial fibrillation burden by 45% and lowered atrial fibrillation-related hospitalizations.

Top Psychiatric Predictors of CVD Risk After Trauma Revealed

A range of psychiatric conditions following trauma were tied to elevated cardiovascular risk, with alcohol use disorder emerging as the leading predictor in both men and women.

Med Op-Ed: Robot-Approved Refills, Ominous VTEs, and More

Prescription renewal systems raise liability and safety questions when clots may signal a catastrophic prognosis, and the merits of writing clinical notes.

Transportation Noise Tied to Stroke Recurrence Risk

Higher residential exposure to transportation noise was associated with increased odds of experiencing another stroke, a prospective cohort study shows.

Tricuspid Repair Cuts Death, HF Hospitalization in Severe TR

Transcatheter tricuspid valve repair added to medical therapy reduced clinical events in patients with severe tricuspid regurgitation, with marked reduction in HF hospitalization.

Aeson Artificial Heart Delivers in Advanced Heart Failure

Results presented at ESC 2026 and published in the European Heart Journal support the Aeson device as a potential option for patients with few remaining treatment alternatives.

Pregnancy Hypertensive Disorders Recur in 15% of Women

The subsequent episode links to a history of severe early-onset hypertensive disorders of pregnancy.

Long-Term Primary Care Linked to Fewer Emergency Admissions

Findings suggest that maintaining stable primary care relationships may support earlier intervention and more efficient use of hospital services.

Venetoclax Worsens Outcomes in Double-Hit Lymphoma

A phase 2 study evaluates the safety and efficacy of adding venetoclax to chemoimmunotherapy for patients with newly diagnosed double-hit lymphoma.

Amputation Tied to Doubled Death Risk in T2D

Patients with type 2 diabetes who undergo lower-extremity amputation have more than double the risk for all-cause and cardiovascular death, independent of established cardiovascular risk factors.

1 in 5 Kids on Long-Term VADs Still Supported at 2 Years

Nearly 1 in 5 children with ventricular assist devices remain on support for more than 6 months, and among that group, 1 in 5 patients are still on the device at 2 years.

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