Can Local Therapy Extend Life in Metastatic Breast Cancer?

Published Date: 13 Mar 2026

For some women with de novo metastatic breast cancer, surgical resection of the primary tumor is associated with longer survival.

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Younger women with high-risk breast cancer often opt for mastectomy, but it may not improve survival or reduce recurrences versus breast-conserving surgery.

Chief Cardiology fellow Yash Varma asks HF expert Ileana Piña for tips on when patients are stable to discharge on guideline-directed medical therapy and if it’s ever ok to de-escalate.

Patients who still smoke heading into lung cancer surgery have a higher complication rate than those who have quit — but their mortality risk is no different, a large retrospective study finds.

Many promising therapies fail because of poor patient selection; Harris warns that only about one third of tumors are truly hypoxic, underscoring the need for precise biomarkers in trials.

Researchers used a blood protein wash to render brain tissue transparent down to 700 µm, witnessing live-firing activity without killing a single neuron.

AstraZeneca said on Thursday that a late-stage trial of Imfinzi, ⁠combined with a targeted therapy prior to a surgery, showed significantly ⁠improved survival rate in...

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