Fixed-Dose Macitentan/Tadalafil Combo Gets FDA Approval for PAH.

Published Date: 29 Mar 2024

One tablet of Opsynvi contains two medications that are frequently prescribed for pulmonary arterial hypertension.

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Latest News

As new Medicaid work mandates start to take effect, patients in some states are asking physicians for waivers, saying they’re too sick or disabled to work. But rules for granting waivers are confusing.

More than 6 million Americans started GLP-1 drugs since 2021 — and a growing share had no documented medical reason for taking them.

Deaths from infection or sepsis increased from 2018 to 2021 but decreased in the following years.

Failure of an anti-inflammatory monoclonal antibody in the randomized trial shouldn’t be seen as negating the role of inflammation in atherosclerotic cardiovascular disease, some experts argued.

A new ACC/AHA guideline restores numeric LDL-C targets while a 150,000-patient CTT reassessment clears most label-listed statin side effects.

Migraine is linked to an earlier onset of stroke, yet young patients with stroke and a history of migraine experience better functional recovery at discharge.

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Pachychoroid Disease Progression Remains Low

Most eyes with pachychoroid features maintained their subtype over 2 years, with progression to pachychoroid neovasculopathy developing in only a small fraction of eyes.

Obesity Class III Linked to Death Risk in Younger Adults

Younger adults with severe obesity face significantly increased risk for mortality, while older adults show minimal differences across obesity classes.

Integrase Inhibitors Safe for Heart in HIV Patients

A Swiss study tracking thousands of people with HIV found no long-term cardiovascular penalty when switching to integrase inhibitor-based therapy, though a small early-year uptick in events warrants clinical attention.

Mild Tremor Tied to Cognitive Decline in Seniors

Even subtle hand tremor in older adults may signal more than just a benign motor quirk — new population data reveal an unexpected cognitive connection.

Cefadroxil Effective for Gram-Positive Bacteremia

Oral cefadroxil shows comparable outcomes to intravenous and alternative oral regimens in treating gram-positive bloodstream infections, a recent study shows.

Dapagliflozin Reduces AKI After Cardiac Surgery

Four doses of the SGLT2 inhibitor dapagliflozin reduce acute kidney injury risk after elective cardiac surgery, with a low incidence of ketoacidosis.

Dexrazoxane May Preserve LV Function in Cancer Survivors

Researchers analyzed echocardiographic data from patients who received dexrazoxane before doxorubicin as part of their treatment for cancer in childhood.

Photon-Counting CT Boosts Stent Fracture Detection

A phantom study shows that photon-counting detector CT significantly improves the detection of visceral endovascular stent fractures compared with conventional CT.

Postpartum Health Coaching Boosts Blood Pressure Control

Health coaching may help close a critical gap in care after a hypertensive pregnancy.

Five Steps to Earlier Heart Failure Detection

Heart failure often hides behind vague complaints. These five primary care steps can help spot it earlier and guide faster, evidence-based treatment.

How to Talk About Exercise When Weight Loss Is Off the Table

In the era of GLP-1 drugs, weight loss is no longer a compelling pitch. Here’s how to reframe physical activity for patients.

Central Adiposity May Reclassify CVD Risk Beyond BMI

Among individuals with normal BMI, elevated waist circumference or waist-to-hip ratio may identify cardiovascular risk beyond BMI.

Allopurinol Offers No Heart Benefit in Kidney Donors

The use of allopurinol leads to significantly lower uric acid levels but shows no effect on heart mass, blood pressure, or insulin sensitivity in healthy living kidney donors, a phase 2b trial finds.

Cardiometabolic Index Can Predict Mortality Risk in T2D

A higher cardiometabolic index is linked to an increased risk for all-cause and cardiovascular mortality in patients with T2D, serving as an effective prognostic tool.

Quarter of Gestational Diabetes Moms Get Early Hypertension

More than 1 in 4 women with recent gestational diabetes developed hypertension at 5 months postpartum, driven primarily by baseline maternal characteristics rather than pregnancy complications.

Retatrutide Trims Weight and A1c in Diabetes

Retatrutide helped patients lose up to 30% of body weight in new trials, among the largest effects yet from a weight-loss drug – but a new safety signal raises questions.

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