What Therapy Would Yield the Best Outcomes In Patients with R/R B-cell ALL?

Speciality: Oncology


Speaker:

Dr. Pawan Kumar Singh | Consultant - Cardiothoracic & Vascular Surgery, Heart & Vascular Institute, Cardiothoracic And Vascular Surgery, Enhanced External Counterpulsation (EECP) Therapy, BLK-Max Super Speciality Hospital

Dr. Manisha Jain | Consultant, Medical Oncology, Cancer Care, MBBS, MD, D.M (Clinical Haematology), Medanta

Dr. Roshan Dikshit | Senior Consultant, Hematology and Bone Marrow Transplant, Aakash Hospital

Dr. Avriti Baveja | M.B.B.S, M.D (Medicine ), D.M. (Clinical Hematology), Himalayan Institute of Medical Sciences

Description:

Welcome to this insightful discussion featuring renowned experts Dr. Pawan Kumar Singh, Dr. Roshan Dikshit, Dr. Manisha Jain, and Dr. Avriti Baveja as they delve into the evolving therapeutic landscape for patients with relapsed/refractory (R/R) B-cell Acute Lymphoblastic Leukemia (ALL). In this comprehensive dialogue, the panel explores cutting-edge treatment modalities, including CAR T-cell therapy, bispecific antibodies, and novel targeted agents, while emphasizing the importance of personalized approaches based on patient-specific factors such as disease biology, prior therapies, and comorbidities. The experts critically evaluate clinical trial data, real-world outcomes, and the role of hematopoietic stem cell transplantation (HSCT) in the context of modern immunotherapies, offering evidence-based recommendations for optimizing patient care.

The discussion further highlights the transformative potential of emerging therapies like blinatumomab and inotuzumab ozogamicin, alongside advancements in CAR T-cell platforms designed to improve efficacy and reduce toxicity. Dr. Singh underscores the significance of monitoring and managing cytokine release syndrome (CRS) and neurotoxicity, while Dr. Dikshit and Dr. Jain elaborate on strategies to overcome resistance mechanisms. Dr. Baveja provides insights into bridging therapies and supportive care measures essential for maintaining patient eligibility for advanced treatments. The panel concludes by addressing challenges in access to innovative therapies in resource-limited settings and advocates for collaborative efforts to enhance clinical trial participation and equitable care delivery.

This engaging session is a must-watch for hematologists, oncologists, and healthcare professionals seeking to stay updated on the latest advancements in R/R B-cell ALL management. The experts’ balanced perspectives on risk-benefit assessments, sequencing of therapies, and future directions in precision oncology provide actionable takeaways for improving patient outcomes. Don’t miss this opportunity to learn from leading minds in the field. Be sure to watch the full video and stay tuned for more thought-provoking discussions in our upcoming series!



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