Clinical Advances in Myelofibrosis From EHA 2023.

Published Date: 01 Jul 2023

Myelofibrosis updates from EHA 2023 cover novel approaches in ruxolitinib-resistant patients, use of BET inhibitors plus JAK inhibitors to deepen response, and luspatercept to treat anemia.

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Drs Marwah Abdalla and Lewis Blevins discuss Cushing syndrome: Why it is frequently missed, how clinicians can screen for it, and how to manage it.

A crossover trial to determine whether ketone ester improves exercise tolerance in HFpEF.

Listener feedback, huge news in the rapidly expanding world of PFA AF Ablation, obesity, and a beautiful trial studying an AI-enhanced diagnostic tool in the office are the topics discussed by John Mandrola, MD, in this week’s podcast.

An overview of MASLD, including the epidemiology, diagnostic approaches, and therapeutic options highlighting the cardiologists’ role in its multidisciplinary management.

Citing The Death of Ivan Ilyich, the authors call for professional societies to jointly embrace a core definition of frailty for cardiovascular care and clinical practice.

Problems with the PREVENT score, a breakthrough in lipid-lowering therapy, a surprising benefit in stroke care, and more thoughts on statins and preventive care of heart disease are the topics John Mandrola, MD, discusses in this week’s podcast.

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RSV Prevention Products Tied to Fewer Kids’ Hospital Visits

The combined use of nirsevimab and maternal respiratory syncytial virus vaccine is linked to a lower burden of severe RSV infection among infants aged 7 months or younger in Washington state.

No Clinical Benefit of Antiamyloids in AD: Review

A major review reports no clinically meaningful benefit from antiamyloid therapies for Alzheimer’s disease, but some experts argue the analysis is skewed because it included failed drug trials.

Low Conscientiousness Linked to Problematic Alcohol Use

A 23-year longitudinal study suggests that lower conscientiousness levels from childhood through adulthood are a necessary condition for developing problematic alcohol use.

Radiologists: Can You Detect Deepfake X-rays?

A study shows radiologists inconsistently identify AI-generated x-rays, highlighting emerging risks for clinical decision-making and data integrity.

BMI in HFpEF: Friend or Foe?

A commentary on the so-called obesity paradox in Heart failure with preserved ejection fraction.

Can DBS Curb Severe Self-Injury in Autism?

A small pilot suggests deep brain stimulation may reshape dysfunctional brain circuits to curb severe self-harming behavior in children with autism.

Loneliness Linked to Lower Memory Scores, Not Faster Decline

In a 6-year study of 10,000 older adults, loneliness was tied to lower memory scores at baseline — but not to a faster rate of decline over time.

New Model Predicts HCC Risk After Hepatitis B Seroclearance

A model with six independent variables predicts the risk for hepatocellular carcinoma after hepatitis B surface antigen seroclearance in patients with chronic hepatitis B.

Rapid Methadone Boost Tied to Better Fentanyl Use Outcomes

A methadone increase in the first 6 days of treatment is linked with better retention and lower opioid toxicity, data indicate.

Does Marital Status Affect Cancer Risk?

A large population-based study found marital status was associated with differences in cancer risk across multiple cancer types.

Phentolamine Eye Drops Ease Presbyopia in Second Randomized Trial

The adrenergic antagonist improved near vision in adults with presbyopia, with over 20 hours of improvement from a single administration in the VEGA-3 trial.

Physical Health Key to Seniors’ Mental Health

Social connections, physical health, freedom from chronic pain, and spiritual engagement are linked to increased likelihood of good mental health in older adults.

New Tool Detects Alcohol in Steatotic Liver Disease

A simple new index may quantify the role of alcohol in steatotic liver disease without expensive testing.

The Fascinating Phenomenon That Is Your Brain on Exercise

A cascade of beneficial effects hits the brain during exercise — with new data on strength training. Helping your patients understand it can be a powerful motivator.

Positive Age Beliefs Linked to Functional Gains

Using Health and Retirement Study data, 31.9% show cognitive gains, and 28% improve gait speed over follow-up — findings that challenge the assumption that decline is inevitable.

Facilitated Cascade Genetic Testing: A New Standard of Care?

A clinician-led approach boosts genetic testing among relatives of people with newly detected pathogenic variants — and could help close a gap in hereditary cancer prevention.

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