Weight-loss drug semaglutide shown to reduce cocaine use in rats

Published Date: 05 Sep 2025

Scientists have found that the diabetes/weight loss drug semaglutide, sold commercially under brand names like Ozempic and Wegovy, significantly reduces cocaine-seeking behavior in rats. This work needs to be confirmed in ...

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Trappsol Cyclo Misses Primary End Point in Phase 3 Trial for Niemann-Pick Disease Type C Isabella Ciccone, MPH

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NeurologyLive® Friday 5 — October 2, 2026 Isabella Ciccone, MPH

Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending October 2, 2026.

Todays Updates

Trappsol Cyclo Misses Primary End Point in Phase 3 Trial for Niemann-Pick Disease Type C Isabella Ciccone, MPH

Findings from the phase 3 TransportNPC study showed that Trappsol Cyclo missed the primary end point in Niemann-Pick type C, but subgroup and survival data support planned 2026 NDA.

NeurologyLive® Friday 5 — October 2, 2026 Isabella Ciccone, MPH

Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending October 2, 2026.

Latest News

In a phase 1/2 study, guanabenz was associated with a 67% lower risk of losing the ability to walk in children with vanishing white matter disease, a rare and devastating leukodystrophy.

From financial incentives to ‘gamification’ of weight loss, researchers are testing ways to help patients lose weight and keep it off.

Sleek-looking disposable e-cigarettes and candy-flavored nicotine pouches are among a range of new products targeting young people and fueling a new wave of tobacco and nicotine addiction, the WHO warned Monday.

In a commentary published by the Journal of the American Medical Association, researchers at Rutgers Health, Harvard University and the University of Pittsburgh discuss the impact of unregulated mobile health and generative ...

The government's new mandate to carry out random oral-fluid roadside drug testing marks a milestone in New Zealand's road safety policy.

Alcohol-related diseases and injuries have the potential to cost the Australian health care system a staggering $68 billion over 60 years if nothing is done to stop the impact.

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Taking prescription opioids for too long can be harmful. Here's how to cut back and stop

Opioids, such as oxycodone, morphine, codeine, tramadol and fentanyl, are commonly prescribed to manage pain. You might be given a prescription when experiencing pain, or after surgery or an injury.

Vaping might seem safer than smoking but your heart could tell a different story

You may have heard that vaping is the "safer" choice than smoking. But what if the very thing designed to protect your health also puts your heart at risk?

Proposed policy calls for reduced nicotine levels in cigarettes

The American Association for Cancer Research (AACR) has endorsed a federal policy that would make cigarettes far less addictive. The proposed policy by the Food and Drug Administration (FDA) sets a maximum nicotine product ...

The 'hard, slow work' of reducing overdose deaths is having an effect

Illicit drug overdoses and the deaths they cause are trending down this year, despite spikes in a handful of states, according to a Stateline analysis of data from the federal Centers for Disease Control and Prevention.

Vaping has slowed progress in cutting teen smoking in NZ—new study

Smoking rates among adults have declined in Aotearoa New Zealand over recent decades, from 18% smoking regularly in 2011/12 to 8% in 2023/24.

A path to safer painkillers: Using cryo-electron microscopy, scientists visualize how opioids engage key brain receptor

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid receptors. What they didn't know—until now—was exactly what happens next.

More than half of young adults in Australia admit to driving drunk the morning after a night out

The belief that "friends do it too" is a major factor in young adults drink-driving (driving drunk) the morning after a night out, according to a study of almost 300 Queenslanders.

People with a gambling disorder are more likely to die by suicide, research finds

Published in BJPsych Open, this is the first UK study to use routinely collected NHS data to identify factors that may predict suicide among people with gambling problems. Using anonymous health care records from Wales covering ...

Closer proximity to cannabis retail stores linked with more cannabis use but less drinking

A statewide study of more than 60,000 adult Oregonians shows that living near cannabis retail stores is associated with a greater tendency toward frequent cannabis use but a lower likelihood of heavy alcohol consumption.

Declining union membership could be making US working-classes less happy, more susceptible to drug overdoses

When fewer people belong to unions and unions have less power, the impact goes beyond wages and job security. Those changes can hurt public health and make people more unhappy.

Tobacco still top cancer killer, despite falling smoking rates

Tobacco remains the leading preventable cause of cancer death in the U.S., despite a dramatic decline in smoking, a new American Cancer Society report says.

Among youth who vape, study finds rise in daily use and difficulty quitting

Since 2019, overall rates of nicotine vaping have declined among U.S. youth, but those who continue to vape are showing signs of worsening addiction, according to new USC research.
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Heterosexist discrimination linked to alcohol use among LGBQ+ students of immigrant origin

Lesbian, gay, bisexual, and queer college students distressed by harassment targeting their sexuality are at a higher risk for alcohol use, especially if they are of immigrant origin. This is among the findings of a new study ...
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