TRIUMPH-4: Retatrutide Delivers Weight Loss, Knee Osteoarthritis Pain Relief

Published Date: 12 Dec 2025

TRIUMPH-4: Retatrutide Delivers Weight Loss, Knee Osteoarthritis Pain Relief

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Datopotamab Deruxtecan Earns New Breast Cancer Indication

The antibody drug conjugate was approved by the FDA for certain patients with triple-negative breast cancer.

Todays Updates

EMA Backs Breast Cancer SERD After FDA No Vote

The recommendation follows phase 3 data showing longer progression-free survival when patients switched to camizestrant plus a CDK4/6 inhibitor.

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Latest News

Lupus contributes substantially to premature mortality in young women, with over 304,000 years of potential life lost in women aged 15-44 years from 2000 to 2015.

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Transforming CIDP Management: Early Diagnosis, Pathophysiology, and the Emerging Role of FcRn Antagonists

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No help from diacerein in randomized trial

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Phase III results put obinutuzumab in line for approval

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American patients report more symptoms and mostly don't agree with doctors on how they've fared

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Advantage plans do a better job than standalone Part D policies, albeit with important gaps

ICE Chief Hospitalized; Metastatic Colon Cancer at Age 26; TENS for Fibromyalgia

Health news and commentary gathered by MedPage Today staff

Dyspnea in Woman With RA Reveals a Diaphragmatic Lipoma

MRI can help differentiate these benign soft-tissue masses from more aggressive liposarcomas

What Caused This Patient's Recurring Eye and Ear Inflammation?

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What Caused Left-Sided Hearing Loss in This 65-Year-Old Man?

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We have met the enemy and it's the sofa, updated guideline indicates

Rheumatic Disease Drugs Help COVID Virus Stick Around Longer, Study Suggests

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Drug Targeting TLRs in Cutaneous Lupus Looks Good in Mid-Stage Studies

— Dose-response signal appears in phase II trial, and all doses are better than placebo

Upadacitinib After TNF Inhibitor Failure Improves RA Control

In patients with active RA, switching to upadacitinib after failure of a single TNF inhibitor is more effective in reducing disease activity at 12 weeks than using a second TNF inhibitor adalimumab.

Early Anti-TNF to Prevent Difficult-to-Treat RA Gains Steam

The availability of TNF inhibitor biosimilars and the cost of treating ‘difficult-to-treat’ RA are making first-line TNF inhibition in early RA more attractive in the UK.

FDA Grants Breakthrough Therapy Designation to Ianalumab, First Potential Sjögren’s Targeted Therapy Victoria Johnson

Novartis plans to submit regulatory applications for ianalumab in early 2026.

FDA Updates Label for Reduced Osteoarthritis Risk With BEAR Implant Over ACL Reconstruction Victoria Johnson

FDA approves a label update for the BEAR implant, which was previously approved in 2020.

FDA Grants Priority Review to Efgartigimod, First Potential Therapy for Seronegative Myasthenia Gravis Victoria Johnson

argenx's efgartigimod-alfa therapy was approved for seropositive generalized myasthenia gravis in 2021.

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