The world's first mRNA vaccine against a deadly disease

Published Date: 15 Mar 2023

A world first: A research team from Tel Aviv University and the Israel Institute of Biology has developed an anti-mRNA drug that is 100% effective against a single type of virus.

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Sepsis Source Affects Early Mortality in Oldest ICU Patients

Among critically ill patients aged 90 and older, the source of sepsis may influence short-term survival more than previously recognized.

One Broken Pathway Drives Aging. Scientists Aim to Fix It

A decline in the functioning of the cellular cleanup pathway drives disease across nearly every organ. Now drugs that restore it are heading toward the clinic.

Ultraprocessed Foods and the Gut Microbiome

Ultraprocessed foods may do more than add calories, with emulsifiers, sweeteners, and dyes linked to gut dysbiosis and a weakened intestinal barrier.

Stress and Eczema: Is the Brain-Skin Axis Real?

Evidence points to a neuroimmune pathway through which psychological stress may amplify skin inflammation, raising questions about future approaches to eczema care.

Glomerular Hematuria in Lupus: Not Always Nephritis

Glomerular hematuria without proteinuria or impaired kidney function in patients with systemic lupus erythematosus may indicate pathology other than lupus nephritis, a study finds.

Nearly 1 in 3 Preemies Show Lung Deficits at Preschool Age

Nearly one third of children born very preterm have abnormal pulmonary findings at preschool age, with greater bronchodilator responsiveness and a higher burden of respiratory risk factors.

Todays Updates

Freeman’s Lobotomy to Deep Brain Stimulation: What Changed?

The history of lobotomy shows the risks for limited evidence and oversight, while modern approaches emphasize targeted treatment, informed consent, and rigorous evaluation.

Wide Variation Seen in Lung Screening False-Positive Rates

US radiologists vary substantially in their reading of low-dose CT lung cancer screens, highlighting a need for measures to help standardize interpretation.

AVD Chemo Regimen Shows Promise in Older Patients With HL

Researchers compare first-line chemotherapy regimens in older patients with classical Hodgkin lymphoma to assess whether AVD is associated with better outcomes in routine care.

Do High-Risk Features of Prostate Cancer Boost HT Benefit?

Researchers analyze individual patient data from five randomized phase 3 trials comparing PORT alone vs PORT plus hormone therapy in patients with recurrent prostate cancer.

How Low Does PSA Need to Go in Metastatic Prostate Cancer?

A new real-world analysis helps clarify the most informative prognostic PSA benchmark in men with metastatic castration-sensitive prostate cancer.

Tissue-Free ctDNA Strongly Prognostic of Recurrence in TNBC

Tissue-free ctDNA may be comparable to tumor-informed assays in detecting molecular residual disease.

Todays Updates

Freeman’s Lobotomy to Deep Brain Stimulation: What Changed?

The history of lobotomy shows the risks for limited evidence and oversight, while modern approaches emphasize targeted treatment, informed consent, and rigorous evaluation.

Wide Variation Seen in Lung Screening False-Positive Rates

US radiologists vary substantially in their reading of low-dose CT lung cancer screens, highlighting a need for measures to help standardize interpretation.

AVD Chemo Regimen Shows Promise in Older Patients With HL

Researchers compare first-line chemotherapy regimens in older patients with classical Hodgkin lymphoma to assess whether AVD is associated with better outcomes in routine care.

Do High-Risk Features of Prostate Cancer Boost HT Benefit?

Researchers analyze individual patient data from five randomized phase 3 trials comparing PORT alone vs PORT plus hormone therapy in patients with recurrent prostate cancer.

How Low Does PSA Need to Go in Metastatic Prostate Cancer?

A new real-world analysis helps clarify the most informative prognostic PSA benchmark in men with metastatic castration-sensitive prostate cancer.

Tissue-Free ctDNA Strongly Prognostic of Recurrence in TNBC

Tissue-free ctDNA may be comparable to tumor-informed assays in detecting molecular residual disease.

Latest News

Among critically ill patients aged 90 and older, the source of sepsis may influence short-term survival more than previously recognized.

A decline in the functioning of the cellular cleanup pathway drives disease across nearly every organ. Now drugs that restore it are heading toward the clinic.

Ultraprocessed foods may do more than add calories, with emulsifiers, sweeteners, and dyes linked to gut dysbiosis and a weakened intestinal barrier.

Evidence points to a neuroimmune pathway through which psychological stress may amplify skin inflammation, raising questions about future approaches to eczema care.

Glomerular hematuria without proteinuria or impaired kidney function in patients with systemic lupus erythematosus may indicate pathology other than lupus nephritis, a study finds.

Nearly one third of children born very preterm have abnormal pulmonary findings at preschool age, with greater bronchodilator responsiveness and a higher burden of respiratory risk factors.

News All Time

Dupilumab Improves Allergic Fungal Rhinosinusitis Outcomes

Dupilumab significantly improves sinus opacification and disease burden in patients with allergic fungal rhinosinusitis.

Childhood Lupus: High Disease Activity Persists in Adulthood

Adults with childhood-onset systemic lupus erythematosus face a strikingly different disease trajectory than those diagnosed later in life, spending less time in the low disease activity state.

Dupilumab Shows Long-Term Benefits in CRSwNP

Dupilumab yields sustained benefits in terms of nasal congestion, sense of smell, and quality of life in patients with CRSwNP over 24 months in a real-world global registry.

First Dust Mite Immunotherapy Cleared for Scotland

Acarizax is now the first house dust mite immunotherapy accepted by the SMC for patients with persistent allergic rhinitis.

Comparative CV Effectiveness of GLP-1s and SGLT2 Inhibitors in T2DM

A multinational, retrospective, new-user active-comparator cohort study using 10 U.S. and non-U.S. administrative claims and EHR databases.

New Score Predicts Mortality Post-Liver Transplant in Kids

A new sepsis score accurately identifies children with the highest risk for mortality after liver transplantation and infection.

Cough Headaches: Should Evaluation Stop at Brain MRI?

Although Chiari malformation is a common cause, persistent cough headaches may also indicate cerebrospinal fluid disorders, vascular lesions, or other structural abnormalities.

Health Rounds: Adjusting Gut Bacteria May Help With Peanut Allergies

We also feature a small study that should reassure women about the safety of becoming pregnant after undergoing CAR T-cell therapy for autoimmune diseases.

Early Treatment May Improve Mononeuritis Multiplex Outcomes

Patients with mononeuritis multiplex associated with rheumatic disease show favorable response to immunosuppressive therapy, although residual deficits may persist in many cases.

Professional Corner: Free Clinic, AHA Leadership, and More

A primary care clinic for uninsured patients is coming to Santa Fe. The American Heart Association names its volunteer leaders, and the AMA launches a new awards program.

Biologics and Infection Risk: Time to Rethink Prevention?

Infection risk varies by biologic target, supporting tailored screening, vaccination, and monitoring rather than a one-size-fits-all prevention strategy.

New BTK Inhibitor Approved for Urticaria

MHRA approves oral BTK inhibitor remibrutinib, offering adults with chronic spontaneous urticaria a new option beyond antihistamines.

Uveitis May Flag Possibility of Axial Spondyloarthritis

Many patients with nongranulomatous acute anterior uveitis may be diagnosed with previously unrecognized axial spondyloarthritis after rheumatologic evaluation.

Uraemic Toxins Tied to Septic AKI Severity, Not Mortality

Higher serum levels of most uraemic toxins are associated with the severity of AKI during septic shock, but toxin trajectories are not independently linked to 28-day mortality, a French study finds.

T1D Tied to Early Fracture Risk, Worse With Kidney Disease

Patients with T1D face a higher risk for any fractures, major osteoporotic fractures, and hip fractures than control individuals without diabetes; the risk increases as DKD becomes more severe.

Lipedema: A Multidisciplinary and Surgical Approach to Care

Speakers at ICO 2026 highlighted the need for earlier recognition, uniform diagnostic criteria, and individualized care that can include lymphatic support, metabolic management, and surgery.

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