The world's first mRNA vaccine against a deadly disease

Published Date: 15 Mar 2023

A world first: A research team from Tel Aviv University and the Israel Institute of Biology has developed an anti-mRNA drug that is 100% effective against a single type of virus.

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Morphine Plus Acetaminophen May Boost Pain Relief in the ED

Intravenous morphine plus acetaminophen provides greater early pain reduction and requires fewer rescue doses than morphine alone in the emergency department, a trial finds.

Albumin Replacement Therapy Shows No Benefit in Septic Shock

Albumin replacement therapy targeting serum levels ≥ 3.0 g/dL does not improve 90-day survival in patients with septic shock in the emergency department, a trial shows.

Mar 13 2026 This Week in Cardiology

Beta-blocker in non-obstructive hypertrophic cardiomyopathy, a head-to-head apixaban vs rivaroxaban RCT, diltiazem vs metoprolol combined with DOAC, and the accuracy of smart watches for AF are the topics John Mandrola, MD, discusses in this week’s podcast.

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New research reveals a clue in the persistent mystery of why eczema is so common in infancy.

The Unexpected Impact of TV Doctors on Patient Trust

From Dr Greene’s hubris to House’s Vicodin addiction to the traumatized doctors in The Pitt, could modern depictions of flawed physicians be doing more harm than good?

Lancet Commission Elevates Global Dermatology Priorities

For the first time, a Lancet Commission is shining a light on the global burden of skin diseases and spurring an action plan.

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Winter Sports and Lower Limb Motor Disability

People with lower limb motor disability need tailored equipment, training, and medical oversight to boost performance while preventing upper limb overload and skin problems.

Can Better Screening Prevent Maternal VTE Deaths?

Nearly half of maternal deaths from venous thromboembolism in France over 12 years were preventable.

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Tight Glycemic Target in Gestational Diabetes Reduces Risks

Tight glycemic targets in gestational diabetes can lower the risk for large-for-gestational-age births without increasing the risk for serious maternal and neonatal complications.

Todays Updates

Winter Sports and Lower Limb Motor Disability

People with lower limb motor disability need tailored equipment, training, and medical oversight to boost performance while preventing upper limb overload and skin problems.

Can Better Screening Prevent Maternal VTE Deaths?

Nearly half of maternal deaths from venous thromboembolism in France over 12 years were preventable.

'Concerning': CRC Continues to Shift Toward Younger Adults

Nearly half of new colorectal cancer cases now occur in people younger than age 65 years, highlighting the need for earlier screening and better symptom awareness.

Tight Glycemic Target in Gestational Diabetes Reduces Risks

Tight glycemic targets in gestational diabetes can lower the risk for large-for-gestational-age births without increasing the risk for serious maternal and neonatal complications.

Latest News

Intravenous morphine plus acetaminophen provides greater early pain reduction and requires fewer rescue doses than morphine alone in the emergency department, a trial finds.

Albumin replacement therapy targeting serum levels ≥ 3.0 g/dL does not improve 90-day survival in patients with septic shock in the emergency department, a trial shows.

Beta-blocker in non-obstructive hypertrophic cardiomyopathy, a head-to-head apixaban vs rivaroxaban RCT, diltiazem vs metoprolol combined with DOAC, and the accuracy of smart watches for AF are the topics John Mandrola, MD, discusses in this week’s podcast.

New research reveals a clue in the persistent mystery of why eczema is so common in infancy.

From Dr Greene’s hubris to House’s Vicodin addiction to the traumatized doctors in The Pitt, could modern depictions of flawed physicians be doing more harm than good?

For the first time, a Lancet Commission is shining a light on the global burden of skin diseases and spurring an action plan.

News All Time

US Kidney Transplant Inequity Narrows for Black Patients

Black patients with failing kidneys are receiving more transplants and spending less time on transplant waiting lists, after decades in which ⁠race-based medical guidelines...

Futile CPR vs Supportive Care: How to Talk DNR

Doing CPR in dying patients with uncorrectable medical conditions is akin to operating on the wrong limb, writes John Mandrola, MD. If DNR conversations explain this better, would more patients sign up?

GLP-1 RAs Underused in Teens With Type 2 Diabetes

Insurance issues may be part of the problem, according to a new analysis.

APC Spending on Specialty Derm Drugs Rapidly Increasing

While a higher proportion of physicians are prescribing biologics, ‘the growth rate has been faster for APCs,’ one of the study authors said.

Vertex to Seek US Approval After Promising Late-stage Results for Kidney Drug

Vertex Pharmaceuticals said on Monday that its experimental drug sharply reduced a key sign of kidney ⁠damage in a late‑stage trial, putting the company on track to seek...

Risk Factors for Early Development of Food Allergies

The study found multiple childhood food allergy risk factors but no link to vaccines.

Extended Dupilumab Dosing Maintains Efficacy in Nasal Polyps

Dupilumab yields rapid reductions in nasal polyp burden and improvements in smell function; these benefits persist with extended dosing intervals.

Doctors Raise Their Voices Against AMR

Healthcare professionals are stepping into the spotlight in Lifeline, a musical that blends medicine, music, and a warning about antimicrobial resistance.

Adrenocortical Carcinoma: Incidence and Survival Over Time

The incidence of adrenocortical carcinoma is stable over time, but the survival for stage IV disease has improved, with the centralisation of care being associated with better survival.

Immunoglobulin A Nephropathy: 5 Treatment Approaches to Know

The treatment landscape for IgA nephropathy is rapidly evolving, with therapies focused on mitigating the effects of nephron loss now being combined with immunomodulatory treatments.

Tolvaptan vs Fluid Limits: Do Costs Outweigh pNa Gains?

Although tolvaptan bests fluid restriction at raising plasma sodium concentration, 19% of patients experience overcorrection of sodium increases.

Pfizer's Eczema Drug Meets Main Goal in Mid-stage Trial, Plans Late-stage Study

U.S. drugmaker Pfizer said on Monday its experimental drug for a ⁠chronic skin disease met the main goal in a mid-stage study.

Outpatient RSV in Kids Younger Than 2 Has Distinct Features

In outpatient care, RSV infections in children younger than 2 years present with distinct clinical features and greater illness burden than infections caused by other respiratory viruses.

Women at Higher Risk for Chronic Cough With Age

Experts report that a chronic cough lasting at least 8 weeks disproportionately affects women, with prevalence increasing with age.

Gene Therapy Injections for Knee OA: Where Are We At?

Developers of gene therapies to treat knee osteoarthritis are taking the familiar intra-articular route to deliver proteins and molecules directly to the site of the disease.

FDA Approves Deucravacitinib as First TYK2 Inhibitor for PsA

In clinical trials, more than half of all patients treated with deucravacitinib achieved at least 20% improvement in American College of Rheumatology response criteria.

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