Virtual screening identifies potential treatments for inherited eye disease that causes blindness

Published Date: 15 Jan 2025

Two new compounds may be able to treat retinitis pigmentosa, a group of inherited eye diseases that cause blindness. The compounds, described in a study published January 14 in the open-access journal PLOS Biology by Beata ...

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Chronic pain is a daily reality for millions of Americans, interfering with their everyday activities and quality of life. An estimated 24.3% of adults in the United States experienced chronic pain in 2023, and current treatment ...

A new study led by Yale's Jennifer Miller, Ph.D., found that medicines are not physically accessible in many of the countries where they are tested for FDA approval. The findings were published in JAMA Internal Medicine.

Animals survive in changing and unpredictable environments by not merely responding to new circumstances, but also, like humans, by forming inferences about their surroundings—for instance, squirrels understand that certain ...

Often dismissed as a minor ailment, migraine is a debilitating neurological disease affecting hundreds of thousands of New Zealanders. At the University of Otago's School of Biomedical Sciences, world-leading research by ...

Scientists think snakes and lizards could help them find new ways to prevent painful kidney stones and gout in people. And it all owes to an evolutionary trick.

The record-breaking federal government shutdown marked yet another impediment to scientific research efforts at the Wistar Institute this year.

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Research gap discovered: 1 in 21 adults affected by mental disorders omitted from global health study

Mental disorders that cause physical symptoms are not included in a major health trends study, despite them impacting as many as 1 in 21 adults, researchers have found.

Scientists complete first drafts of developing mammalian brain cell atlases

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Slowed by sound: Mouse model of Parkinson's disease shows noise affects movement

In the development of Parkinson's disease, it may not be a good idea to turn the amp to 11. High-volume noise exposure produced motor deficits in a mouse model of early-stage Parkinson's disease, and established a link between ...

'Molecular glues' and 'bumpers' offer new hope for precision medicines

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest ...

Astringent, sharper mind: Flavanols can trigger brain activity for memory and stress response

Astringency is a dry, puckering, rough, or sandpapery sensation in the mouth caused by plant-derived polyphenols. Polyphenols, including flavanols, are well known for risk reduction in cardiovascular diseases.

Opening the door to a vaccine for multiple childhood infections

A vaccine that tackles the bacteria that cause up to 200 million childhood infections every year could be possible, experts say.

Hundreds of animal studies on brain damage after stroke flagged for problematic images

A new study has identified over 240 scientific publications on animal models of hemorrhagic stroke that contain potentially problematic images, thereby raising concerns about the trustworthiness of the body of literature ...

Decentralized future: Expanding clinical trials by allowing people to participate from home

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In drug trials, lack of oversight of research ethics boards could put Canadian patients at risk

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Discovery of 'doorstop' for brain's electrical gates may open path to new therapies for neurodegenerative conditions

As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At Cold Spring Harbor Laboratory (CSHL), scientists have turned their attention to the tiny pores that let charged ions ...

WHO's priorities shaped by its reliance on grants from donor organizations, study suggests

The World Health Organization's (WHO's) priorities are being skewed by its increasing reliance on donations from organizations such as the Gates Foundation (previously known as the Bill and Melinda Gates Foundation), which ...

Opt-out organ donation policies may reduce organ supply

Every day, 17 Americans die while waiting for an organ transplant. Opt-out organ donation policies, which enroll everyone into post-mortem donation programs by default unless people choose to opt out, have been touted as ...

New Hampshire man resumes dialysis after record 271 days living with a pig kidney

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Liver transplantation utilizing grafts donated after euthanasia is feasible, study suggests

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A 'bird's eye view' of how human brains operate

A new study provides the best evidence to date that the connection patterns between various parts of the human brain can tell scientists the specialized functions of each region.

Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor

Deciphering how the GR forms oligomers—through the binding of several subunits—opens a crucial avenue for developing more selective drugs. These new drugs could modulate this association and thus minimize serious adverse ...

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