Cardinal Health, McKesson, Georgia dominates opioid trials

Published Date: 08 Mar 2023

At a trial in Georgia on Wednesday, three drug traffickers won a case brought by the family of a drug addict, accusing the company of selling drugs.

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Human gene PARP14 could be novel target for viral diseases or immune-mediated disorders

Researchers at the University of Kansas have discovered a human gene, the protein PARP14, plays a role in regulating interferon, part of the body's innate immune system. Their study, appearing in the journal mBio, could guide ...

Men, women face different challenges with COPD, bronchiectasis, and NTM lung disease

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Gene therapy for sickle cell and β-thalassemia works by disrupting three-dimensional genome structure

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Better treatments buoy multiple-myeloma patients, bound by research cuts and racial disparities

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Todays Updates

Better treatments buoy multiple-myeloma patients, bound by research cuts and racial disparities

For more than a year, Diane Hunter, now 72, had been experiencing vague symptoms—pain in her spine and hips, nausea, exhaustion, thirst, and frequent urination. Her primary care physician had ruled out diabetes before finally ...

Newly identified T-cell subtype may explain treatment-resistant childhood leukemia

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Despite the capability of antiretroviral drugs to suppress HIV to undetectable levels, some people living with the human immunodeficiency virus can't reach the goal of viral imperceptibility even with daily doses of the potent ...

Researchers at the University of Kansas have discovered a human gene, the protein PARP14, plays a role in regulating interferon, part of the body's innate immune system. Their study, appearing in the journal mBio, could guide ...

Men and women with chronic obstructive pulmonary disease (COPD), bronchiectasis, and nontuberculous mycobacterial (NTM) lung disease report differences in symptoms, mental health, disease burden, and other patient-reported ...

A three-month program of resistance exercise can help improve the physical and mental well-being of people with long COVID, according to newly published research.

You've been through winter lurgies and escaped the start of spring free of hay fever. Now you wake up with a sniffle you can't seem to shake.

Scientists at St. Jude Children's Research Hospital and Northwestern University identified a previously unknown treatment opportunity for sickle cell disease and β-thalassemia. The discovery, published in Blood, is based ...

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Eczema symptoms unchanged by daily or weekly bathing, study shows

A study has found that people with eczema are able to bathe either daily or weekly, without any impact on their symptoms.

Global study finds stable acute kidney injury mortality with shifting age patterns

A five-year study has revealed a stability in global acute kidney injury (AKI)–related mortality rates with differing patterns that indicate a rising concentration of mortality in older populations and higher socioeconomic ...

Flu season peak is still to come this year: Is it too late to get a flu shot?

While flu shot campaigns and initiatives start around the end of the summer, the peak season for flu is still weeks away.

Quality improvement intervention may help prevent deaths from metformin-associated lactic acid

Metformin-associated lactic acidosis (MALA) is a rare but serious adverse effect of the diabetes drug metformin in which the body accumulates too much lactic acid. Investigators developed and tested a protocol for diagnosis ...

Conservative care vs. dialysis: Model shows which is better for individual advanced chronic kidney disease patients

It can be challenging to identify which patients with advanced chronic kidney disease (CKD) will most benefit from conservative care rather than initiating dialysis.

Kidney transplant waitlisting: A potentially better way to optimize the timing

The current kidney transplant waitlisting criterion is based on a single measurement of kidney function (estimated glomerular filtration rate [eGFR] ≤20 ml/min/1.73 m2) and does not consider an individual's risk of progressing ...

Early HIV drugs give immune system a brief reprieve before dysregulation returns, study finds

Despite effective HIV medication, the immune system of people with HIV remains disrupted in the long term.

Glycosylation enzyme selectivity in mouse kidneys shows promise for future disease research

Glycans are important complex carbohydrates found on cell surfaces that serve crucial roles in cell-to-cell communication, structure, and protection. They are attached to many proteins in the body, and their attachment differs ...

Alternate proteins from the same gene can contribute differently to health and rare disease

Around 25 million Americans have a rare genetic disease, and many of them struggle with not only a lack of effective treatments, but also a lack of good information about their disease. Clinicians may not know what causes ...

Coronavirus replication relies on newly identified host enzyme, study finds

A research team at Ruhr University Bochum, Germany, has identified a previously unknown cellular mechanism crucial to the replication of coronaviruses: c-Jun N-terminal kinase (JNK) is activated during infection with human ...

More Americans are on dialysis. Could more safely wean off it?

Weaning patients with acute kidney injury (AKI) from dialysis while they are still hospitalized may save them from remaining on the treatment for the rest of their lives, according to a new study led by UC San Francisco.

Women are three times more likely than men to get severe long COVID: Here's why

Research published today in Cell Reports Medicine reveals key biological differences that may explain why women with long COVID—especially those who develop chronic fatigue syndrome—tend to experience more severe and ...

Disagreement between two kidney function tests predicts serious health problems

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Chronic kidney disease is now the ninth leading cause of death, global analysis finds

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Study uncovers glomerular disease outcomes across the lifespan

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Intensive blood pressure lowering could benefit almost all adults with hypertensive chronic kidney disease

An analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) indicates that nearly all adults with chronic kidney disease (CKD) would have benefits that outweigh the harm from a systolic blood pressure target of ...

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