Amylyx Begins Phase 1 LUMINA Study of CAPN2-Targeting Agent for ALS

Published Date: 15 Apr 2025

The phase 1 LUMINA trial evaluates Amylyx Pharmaceuticals' AMX0114, an antisense oligonucleotide targeting calpain-2, as a potential therapy for ALS by focusing on safety, tolerability, and biomarkers tied to disease progression.

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