S2 Episode 5: DNA Repair and Replication Stress in Endometrial Cancer

Published Date: 15 May 2025

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer.

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Optimizing UC Therapy in the Presence of Comorbidities

Dr Corey Siegel discusses the importance of individualized therapy selection for ulcerative colitis in the presence of comorbidities.

ESMO Update: New Guidance for Rare Uveal Melanoma

Dr Teresa Amaral breaks down the essential new guidelines for uveal melanoma. Stay ahead of the latest standards in patient care.

A New Ultrapotent Opioid Emerges: What Is Cychlorphine?

Dr Robert Glatter speaks with toxicologist Dr Lewis Nelson about cychlorphine, a newly emerging synthetic opioid linked to fatal overdoses, and what clinicians should understand about detection, naloxone response, and the evolving drug landscape.

Soccer ‘Headers’ Acutely Raise Brain Damage Biomarkers

Study findings are concerning, but will the world’s most popular sport ban the practice of heading the ball?

Lipid Guidelines: Four Major Concerns

Too many Class I recommendations lacking supporting data from randomized trials and intellectual conflicts of interest are among John Mandrola’s complaints about the ACC/AHA guidelines on dyslipidemia.

Canadian EHR Interoperability Weak, Uneven, Harming Patients

Most Canadian physicians use electronic health records, but a lack of connectivity means that patient health information remains siloed across different software programs.

Todays Updates

NP-Led Outreach Ups Cancer Screening in Rural Women Veterans

A nurse practitioner-led outreach program improves the rates of breast and cervical cancer screening among women veterans in rural areas, a retrospective study shows.

Less Mental Decline With Darolutamide vs Enzalutamide in PC

Over half of patients in a randomized trial switch from enzalutamide to darolutamide because of cognitive issues; no one switches in the opposite direction.

Todays Updates

NP-Led Outreach Ups Cancer Screening in Rural Women Veterans

A nurse practitioner-led outreach program improves the rates of breast and cervical cancer screening among women veterans in rural areas, a retrospective study shows.

Less Mental Decline With Darolutamide vs Enzalutamide in PC

Over half of patients in a randomized trial switch from enzalutamide to darolutamide because of cognitive issues; no one switches in the opposite direction.

Latest News

Dr Corey Siegel discusses the importance of individualized therapy selection for ulcerative colitis in the presence of comorbidities.

Dr Teresa Amaral breaks down the essential new guidelines for uveal melanoma. Stay ahead of the latest standards in patient care.

Dr Robert Glatter speaks with toxicologist Dr Lewis Nelson about cychlorphine, a newly emerging synthetic opioid linked to fatal overdoses, and what clinicians should understand about detection, naloxone response, and the evolving drug landscape.

Study findings are concerning, but will the world’s most popular sport ban the practice of heading the ball?

Too many Class I recommendations lacking supporting data from randomized trials and intellectual conflicts of interest are among John Mandrola’s complaints about the ACC/AHA guidelines on dyslipidemia.

Most Canadian physicians use electronic health records, but a lack of connectivity means that patient health information remains siloed across different software programs.

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A Primary Care Primer on Alzheimer’s Blood Tests

Alzheimer’s management may slowly be making its way to primary care, so The Curbsiders unpack the latest on blood-based biomarkers and antiamyloid therapies.

S3 Episode 3: Endometrial Cancer: Research, Early Detection, and Treatment

Drs Ursula Matulonis and Jessica St. Laurent discuss endometrial cancer research, funding, early detection, and treatment, including the impact of GLP-1 receptor agonists.

MASH Screening Made Simple: A 4-Step Guide

MASH is incredibly common, but easily missed. Dr Neil Skolnik breaks down the new AGA clinical pathway to help PCPs confidently screen and treat patients.

Differential Diagnosis of Suspected Pulmonary Fibrosis and Efficacy of Approved Therapies

Experts review the differential diagnosis of suspected IPF, highlighting how a multidisciplinary approach confirmed the diagnosis and informed selection of optimal antifibrotic therapy.

Adult With Established RA and Symptoms of ILD/PPF

A 50-year-old man with rheumatoid arthritis and symptoms of interstitial lung disease or progressive pulmonary fibrosis is evaluated by experts. Treatment options and care priorities are discussed.

S4 Episode 3: How Much Monitoring Is Enough in Psoriasis Care?

Dr Steven Feldman joins Drs Jennifer Cather and Brad Glick to discuss how much monitoring systemic psoriasis treatments really require in modern practice.

The Half-Life of Medical Certainty

Medical knowledge is always evolving. For his 100th column, Dr Kenny Lin reflects on how his views on cancer screening, blood pressure, and health policy have changed.

Infographic: How Much a Doctor’s Average Pay in the US Rose

On average, a physician in the US earned 3% more in 2025, a Medscape survey found. There was no major difference in compensation gains for primary care doctors vs specialists.

Early Multimodal Therapy Restores Hairline in a Woman

A 36-year-old woman with a 2-year history of hairline recession and eyebrow thinning shows marked regrowth after early multimodal therapy with dutasteride, tofacitinib, and intralesional steroids.

Man With Spinal Compression From Hepatocellular Carcinoma

The cervical biopsy was nondiagnostic despite imaging and PET suggesting aggressive disease; a targeted lumbar biopsy ultimately confirmed metastatic hepatocellular carcinoma.

From Pixels to Prescriptions: AI in Oncology Pathology

Digital pathology AI is moving from detection to treatment decisions. In part 2 of this series, here’s what’s FDA-cleared — and how it changes care in oncology practice.

Woman With Lateral Neck Cyst From Fourth Branchial Cleft

An uncommon congenital fourth branchial cleft cyst presents after exercise as a painless, mobile posterior neck mass, highlighting the need for prompt imaging and surgery.

A Man With Severe Gallbladder Dyskinesia

Severe gallbladder dysfunction may present without stones: a case of EF 2% on HIDA in a patient with fatty-meal pain whose pathology showed mild chronic cholecystitis.

Early PsA Detection: Biomarkers and Genetics

Dr Vinod Chandran discusses biomarkers, genetics, and clinical features that assess risk for psoriatic arthritis.

Precision Nutrition for Better Clinical Outcomes

Precision nutrition integrates genetics, the gut microbiome, metabolomics and lifestyle data to tailor dietary therapy promising better clinical outcomes.

When to Operate on a Pancreatic Cyst

More incidental pancreatic cysts are being found with modern imaging; physicians must weigh MRI surveillance against high risk surgery based on size, growth, and duct dilation.

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