Neoadjuvant immunotherapy improves outcomes in high-risk melanoma patients.

Published Date: 02 Mar 2023

High-risk melanoma patients who received the drug pembrolizumab before or after surgery to remove the cancer had a higher risk of developing melanoma than those who did not have a similar condition that eliminated cancer cells.

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Evidence for tVNS Stronger for Anxiety Than Cognition

Transcutaneous vagus nerve stimulation was associated with reduced anxiety severity but showed no significant benefit for working memory or inhibitory control in healthy adults.

Delirium After Surgery Linked to Lasting Loss of Cognition

Delirium after surgery is associated with lasting decline in cognition in older adults, and rehospitalizations may not explain this association.

RSV More Common Than hMPV in Adults With Chronic Illness

In adults with chronic underlying health conditions, respiratory syncytial virus is detected more often than human metapneumovirus, especially in inpatient settings, a meta-analysis finds.

No Gender Disparity in Deaths After Anaphylaxis

Hospital stay, hospital charges, and other secondary outcomes also were similar between male and female patients.

When AI Makes the Call, Doctors May Take the Blame

For all its promise and computational power, will AI in clinical medicine overcome physicians’ concerns?

New Artificial Neurons Cause Living Brain Cells to Fire

An array of artificial neurons printed on a flexible wafer produce spiking waveforms closely matching biological action — and drive living mouse brain cells to fire.

Todays Updates

Induction Immunotherapy Has Durable Survival Benefit in LACC

Patients with locally advanced cervical cancer who receive dual checkpoint blockade before standard chemoradiation have high 3-year survival, but outcomes are poorer for those with ‘cold’ tumors.

Todays Updates

Induction Immunotherapy Has Durable Survival Benefit in LACC

Patients with locally advanced cervical cancer who receive dual checkpoint blockade before standard chemoradiation have high 3-year survival, but outcomes are poorer for those with ‘cold’ tumors.

Latest News

Transcutaneous vagus nerve stimulation was associated with reduced anxiety severity but showed no significant benefit for working memory or inhibitory control in healthy adults.

Delirium after surgery is associated with lasting decline in cognition in older adults, and rehospitalizations may not explain this association.

In adults with chronic underlying health conditions, respiratory syncytial virus is detected more often than human metapneumovirus, especially in inpatient settings, a meta-analysis finds.

Hospital stay, hospital charges, and other secondary outcomes also were similar between male and female patients.

For all its promise and computational power, will AI in clinical medicine overcome physicians’ concerns?

An array of artificial neurons printed on a flexible wafer produce spiking waveforms closely matching biological action — and drive living mouse brain cells to fire.

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Moderna's MRNA Flu Vaccine Backed by FDA Advisers

Advisers to the U.S. Food and Drug Administration on Thursday backed approval of Moderna's flu vaccine for adults aged 50 and older, saying its benefits outweigh its risks,...

Mycobacteria May Predict Graft Failure After Lung Transplant

Early isolation can be a biomarker for patients at increased risk for poor outcomes.

Safety Gaps Put Patients at Risk Across NHS Pathways

NHS patients may face delays in accessing specialist care because of accountability failures and data-sharing gaps across regional pathways, HSSIB has warned.

Moderna Flu Shot Data May Support Use in Older Adults, US FDA Staff Says

U.S. Food and Drug Administration staff reviewers said on Tuesday data demonstrating an immune response to Moderna's flu shot may support effectiveness in adults ⁠65 years...

Ebola Risk for World Cup Is 'Extremely Low', but US Is Ready, Experts Say

The risk that a traveler infected with Ebola could arrive in the United States during the 2026 World Cup tournament that kicked off last week is low but not zero, and if...

US Paying Almost $25,000 a Month to Store Unusable Contraceptives Stuck in Belgium

The United States is spending almost $25,000 every month to store contraceptives in Belgium that were originally bought for use in poorer nations but are ⁠now mainly...

RCPsych: Make Mental Healthcare a Priority, Not a Privilege

The UK must choose between investing in mental healthcare for all or accepting a postcode lottery, the outgoing RCPsych president warns.

VR May Help Curb Cravings in Substance Use Disorder

Virtual reality-based interventions are associated with significantly reduced cravings in patients with various substance use disorders, a new meta-analysis shows.

EMA Holds Valproate Precautions Despite Mixed Evidence

EMA has found inconsistent data on developmental disorders in children of fathers using valproate before conception and retains existing precautions.

Infections Tied to Asthma Attacks on Benralizumab Therapy

In patients with eosinophilic asthma on benralizumab, attacks often feature airway neutrophilia, respiratory viruses, and microbiome shifts, indicating infections are a key cause of exacerbations.

Housing Instability Can Threaten Diabetic Retinopathy Care

Analysis of electronic health record data shows unhoused patients with diabetes have more severe diabetic retinopathy and higher rates of vision-threatening complications than stably housed patients.

Congo's Ebola Outbreak Spreads to New Health Zones

Congo's Ebola outbreak has spread ⁠to three new health zones, according to ⁠a government report published on Thursday that ⁠showed the ‌number of confirmed cases had risen...

India Raises Price Cap on Cancer Drugs to Tackle Shortage

India's drug price regulator raised ceiling rates for two key platinum-based cancer drugs by 50% after a surge ⁠in raw material costs triggered widespread shortages,...

Good Outcomes with Ublituximab in First Real-World Study

Even though the real-world patients in a phase 4 study were older and heavier, ublituximab provided safety and tolerability at least comparable to that in 2 pivotal trials.

Congo’s Ebola Outbreak Spreads to New Health Zone

Congo's Ebola outbreak has spread to a new health zone in the northeastern ⁠province of Ituri, authorities said on Wednesday, as fresh infections underline sustained...

Valencia Floods Highlight Missing Hospital Protocols

A cold snap that hit hundreds of thousands showed how quickly hospitals can lose order, with radiology calling for empathy, leadership, and real disaster protocols.

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Perioperative Anti-PD-1 in Soft-Tissue Sarcoma Boosts Disease-Free Survival

According to a study, taking part in a clinical trial for cancer may not actually increase survival.

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Durvalumab Wins FDA Approval in Limited-Stage SCLC

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If CD19 CAR T-Cell Therapy Fails in Lymphoma, Try a CD22 Version

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