Neoadjuvant immunotherapy improves outcomes in high-risk melanoma patients.

Published Date: 02 Mar 2023

High-risk melanoma patients who received the drug pembrolizumab before or after surgery to remove the cancer had a higher risk of developing melanoma than those who did not have a similar condition that eliminated cancer cells.

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Bipolar Disorder Linked to Higher Mortality in Older Adults

Bipolar disorder is associated with a 72% increased risk for mortality over 8 years in older adults compared with the general population, a new prospective study shows.

Prostate Surgery Leakage Improves Over 12 Months

About 1 in 5 patients develop urinary incontinence 3 months after thulium fiber laser enucleation of the prostate, with rates decreasing over 12 months.

Age and MRI Features Predict MS Odds After Initial Symptoms

Younger age at onset, multifocal symptoms, and specific MRI findings are associated with increased odds of multiple sclerosis diagnosis after a first demyelinating event.

Nirsevimab Linked to Lower Risk for IPD Hospitalizations

Nirsevimab immunization in children younger than 12 months is linked to a lower risk for hospitalization for invasive pneumococcal disease, a French nationwide analysis shows.

‘Big Beautiful’ Law Tests Rural Hospital Lifeline

A century-old hospital near Michigan’s southern border was one of the nation’s first to convert into a new emergency-focused model Congress created to save rural care.

Romanian Healthcare Workers End Strike Over Pay, Staffing

Romanian healthcare workers ended a nationwide strike on ⁠Friday as the country's caretaker government approved new hires in ⁠short-staffed state hospitals.

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Dupilumab Improves Allergic Fungal Rhinosinusitis Outcomes

Dupilumab significantly improves sinus opacification and disease burden in patients with allergic fungal rhinosinusitis.

Fecal Transplant Raises Peanut Tolerance

Oral fecal microbiota transplant raises the amount of peanut that some highly allergic adults can tolerate, serving as proof of concept for microbiome-based food allergy therapy.

Dupilumab Shows Long-Term Benefits in CRSwNP

Dupilumab yields sustained benefits in terms of nasal congestion, sense of smell, and quality of life in patients with CRSwNP over 24 months in a real-world global registry.

Childhood Lupus: High Disease Activity Persists in Adulthood

Adults with childhood-onset systemic lupus erythematosus face a strikingly different disease trajectory than those diagnosed later in life, spending less time in the low disease activity state.

First Dust Mite Immunotherapy Cleared for Scotland

Acarizax is now the first house dust mite immunotherapy accepted by the SMC for patients with persistent allergic rhinitis.

Todays Updates

Dupilumab Improves Allergic Fungal Rhinosinusitis Outcomes

Dupilumab significantly improves sinus opacification and disease burden in patients with allergic fungal rhinosinusitis.

Fecal Transplant Raises Peanut Tolerance

Oral fecal microbiota transplant raises the amount of peanut that some highly allergic adults can tolerate, serving as proof of concept for microbiome-based food allergy therapy.

Dupilumab Shows Long-Term Benefits in CRSwNP

Dupilumab yields sustained benefits in terms of nasal congestion, sense of smell, and quality of life in patients with CRSwNP over 24 months in a real-world global registry.

Childhood Lupus: High Disease Activity Persists in Adulthood

Adults with childhood-onset systemic lupus erythematosus face a strikingly different disease trajectory than those diagnosed later in life, spending less time in the low disease activity state.

First Dust Mite Immunotherapy Cleared for Scotland

Acarizax is now the first house dust mite immunotherapy accepted by the SMC for patients with persistent allergic rhinitis.

Latest News

Bipolar disorder is associated with a 72% increased risk for mortality over 8 years in older adults compared with the general population, a new prospective study shows.

About 1 in 5 patients develop urinary incontinence 3 months after thulium fiber laser enucleation of the prostate, with rates decreasing over 12 months.

Younger age at onset, multifocal symptoms, and specific MRI findings are associated with increased odds of multiple sclerosis diagnosis after a first demyelinating event.

Nirsevimab immunization in children younger than 12 months is linked to a lower risk for hospitalization for invasive pneumococcal disease, a French nationwide analysis shows.

A century-old hospital near Michigan’s southern border was one of the nation’s first to convert into a new emergency-focused model Congress created to save rural care.

Romanian healthcare workers ended a nationwide strike on ⁠Friday as the country's caretaker government approved new hires in ⁠short-staffed state hospitals.

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Gene Therapy Delivers Sustained Retinal Protection

People with age-related macular degeneration maintain vision and cut their need for supplemental injections by 90% 5 years after receiving gene therapy.

Online Harassment: Should Doctors Stay on Social Media?

Online harassment increasingly targets physicians who share evidence-based information, prompting calls for stronger institutional support and safer public engagement.

Post-Pandemic Burnout: NP, PAs Face Different Challenges

The struggles advanced practice practitioners face are different than those that physicians deal with. But the threats are the same.

Ethical Conflict Common in Maternity Care

Providers who work as midwives, in both inpatient and outpatient settings, in southern US states, or who do not have kids may face the most ethical conflicts over drug testing and child welfare reporting.

Sugammadex Reduces Post-Op Lung Complications

Reversal of neuromuscular block with sugammadex reduces the risk for post-op pulmonary complications or death compared with neostigmine in older adults undergoing major abdominal or thoracic surgery.

Faricimab May Aid Hard-to-Treat Macular Degeneration Cases

Faricimab may stabilize vision, reduce retinal fluid and thickness, and cut treatment burden in difficult-to-treat cases of wet age-related macular degeneration.

Delays Harmless for Most Macular Degeneration Patients

Waiting for prior authorization of drugs affects a small portion of patients with age-related macular degeneration, resulting in vision loss.

Sri Lanka Uses Air Force Drones to Tackle Spreading Dengue Outbreak

Sri Lanka's public health services and hospitals are battling the worst outbreak of mosquito-borne dengue in nearly a decade, and turning to the island nation's armed...

A 3-Week Steroid Course Falls Short in Pneumonitis

In patients with mild immune-related pneumonitis, a shorter 3-week corticosteroid regimen does not meet noninferiority compared with the standard 6-week taper.

Cefazolin Noninferior to Penicillins for MSSA Bacteremia

Cefazolin is noninferior to antistaphylococcal penicillins for methicillin-susceptible Staphylococcus aureus bacteremia and is associated with a lower risk for acute kidney injury.

Tentacular Cyclosporiasis Outbreak Stymies Epidemiology Efforts

Confirmed case count across 34 states is five times the number reported last summer, the CDC says.

Transport Of Dead Bodies Within Congo Risks Further Ebola Spread, UN Agency Warns

The transport of Ebola victims' bodies between different areas of the Democratic Republic of Congo, often for funerals in their home communities, risks further ⁠spreading...

Noninvasive Ventilation May Lower Tracheostomy Need in BPD

In preemies with bronchopulmonary dysplasia on home respiratory support, noninvasive positive airway pressure is linked to shorter hospital stays and less healthcare use than tracheostomy ventilation.

Ensitrelvir Reduces COVID Risk Among Contacts Post-Exposure

Household contacts who initiate ensitrelvir vs placebo within 72 hours of symptom onset in the index patient have lower risk of developing COVID, with no apparent safety concerns.

How to Teach Professionalism? Ditch the Deficiency Focus

Teaching professionalism in medical school is required, but how best to do it? Move beyond a deficiency focus, experts say. Emphasize positive examples of professionalism.

Anemia Leads List of Factors That Affect BLVR Failure

Recognizing the impact of comorbidities may guide patient selection and improve outcomes.

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