Neoadjuvant immunotherapy improves outcomes in high-risk melanoma patients.

Published Date: 02 Mar 2023

High-risk melanoma patients who received the drug pembrolizumab before or after surgery to remove the cancer had a higher risk of developing melanoma than those who did not have a similar condition that eliminated cancer cells.

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Switching Dialysis Modalities Ups Mortality in Older Adults

Switching from peritoneal dialysis to hemodialysis is independently associated with increased mortality risk in adults aged 80 years or older.

Shifting the Weight-Loss Focus: More Than Pounds Lost

Every new weight-loss medication seems to promise a greater quantity of weight loss, but growing numbers of experts say it’s crucial to balance quality with quantity of weight loss.

Cortical Atrophy Signals Progression in Early-Onset AD

Baseline cortical atrophy within a signature region of early-onset Alzheimer's disease detected on MRI predicts progression from mild cognitive impairment to dementia.

The Hidden Stress of Returning to Clinic After Vacation

A packed schedule, backlogged results, and administrative overload can make the first day back after vacation feel more punishing than a normal workday.

Three-Step Triage May Speed Assessment of Rheumatic Diseases

A three-step triage system may help reduce wait times for patients with inflammatory rheumatic and musculoskeletal disease, although it may still miss some diagnoses.

Breaking the Lab Habit: Rethinking Daily Hospital Testing

Not every patient needs routine daily testing. Breaking the habit can save money and improve patient health. But some habits are hard to break.

Todays Updates

A New PARADIGM? Azacitidine-Venetoclax Tops Chemo in AML

The less-intensive drug combination outperforms standard induction chemotherapy in fit patients with acute myeloid leukemia.

Todays Updates

A New PARADIGM? Azacitidine-Venetoclax Tops Chemo in AML

The less-intensive drug combination outperforms standard induction chemotherapy in fit patients with acute myeloid leukemia.

Latest News

Switching from peritoneal dialysis to hemodialysis is independently associated with increased mortality risk in adults aged 80 years or older.

Every new weight-loss medication seems to promise a greater quantity of weight loss, but growing numbers of experts say it’s crucial to balance quality with quantity of weight loss.

Baseline cortical atrophy within a signature region of early-onset Alzheimer's disease detected on MRI predicts progression from mild cognitive impairment to dementia.

A packed schedule, backlogged results, and administrative overload can make the first day back after vacation feel more punishing than a normal workday.

A three-step triage system may help reduce wait times for patients with inflammatory rheumatic and musculoskeletal disease, although it may still miss some diagnoses.

Not every patient needs routine daily testing. Breaking the habit can save money and improve patient health. But some habits are hard to break.

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Size Matters for Chest Tubes

New data show similar outcomes with large-bore and small-bore chest tubes in patients with pneumothoraces.

UnitedHealthcare to Drop Prior Authorization Requirements for Range Of Conditions From Oct. 1

UnitedHealth's insurance unit said on Tuesday that a broad range of conditions will no ⁠longer need prior approval, effective October 1, as it aims to eliminate prior...

Rilzabrutinib May Be Promising in IgG4-Related Disease

Rilzabrutinib treatment is associated with a reduction in disease activity in patients with IgG4-related disease and enables most patients to discontinue glucocorticoids without experiencing flares.

What to Know About ‘Musculoskeletal Syndrome of Menopause’

Is new joint pain in perimenopause simple arthralgia or underlying inflammatory arthritis? Learn key diagnostic steps, seronegative RA risks, and hormone replacement therapy insights.

Strategies to Optimize Sepsis Outcomes

Multi-society position paper presents strategies for improvement at the hospital and systems level.

MRI Pattern May Forecast MCI to Dementia Timeline

An MRI-defined pattern of cortical atrophy may help identify patients with early-onset Alzheimer’s disease at risk for more rapid progression from MCI to dementia.

At-Home Lecanemab: What Does It Mean for Alzheimer’s Care?

At-home subcutaneous lecanemab may ease the burden of frequent infusions, but clinicians still face key questions about patient selection, training, ARIA monitoring, adherence, and access.

Paternal Valproate Use Not Tied to NDDs in Offspring

Paternal exposure to valproate during spermatogenesis is not tied to a risk for neurodevelopmental disorders or congenital malformations in offspring, research shows.

Early Oseltamivir Tied to Lower Hospitalization Risk in Flu

Among adult veterans, oseltamivir treatment initiated within 6 hours of influenza diagnosis is associated with a reduced risk for hospitalization.

AI Outperforms Gene Sequencing for Lung Nodule Triage

Interpret findings with caution, but AI-based radiomics may help curb unnecessary procedures.

Discharge Support Remains Weak Spot in CQC Patient Survey

The CQC's 2025 survey of 58,000 patients found rising satisfaction overall, but discharge planning remains an area of difficulty.

Are Universal Digital Mental Health Interventions Effective?

In children without diagnosed mental health conditions, digital interventions are associated with small psychological improvements.

Canadian Bill Intended to Close Gaps in Women’s Healthcare

The comprehensive bill takes a multipronged approach to improving women’s health within a framework intended to keep future governments accountable.

West Nile Virus Infection Causes One Death in the Netherlands

A person has died in a Dutch hospital after ⁠contracting the West Nile virus in the Netherlands, the country's public ⁠health institution RIVM said on...

Statins Tied to Fewer Respiratory Infections in Older Adults

Among older adults unvaccinated against influenza, starting statins is associated with a lower risk for hospitalisation with pneumonia or other acute respiratory infections.

GCA Patients Often Need Long-Term Glucocorticoids

Despite rapid diagnosis and guideline-based tapering, a substantial proportion of patients with giant cell arteritis remain dependent on glucocorticoid therapy for years.