Neoadjuvant immunotherapy improves outcomes in high-risk melanoma patients.

Published Date: 02 Mar 2023

High-risk melanoma patients who received the drug pembrolizumab before or after surgery to remove the cancer had a higher risk of developing melanoma than those who did not have a similar condition that eliminated cancer cells.

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Freeman’s Lobotomy to Deep Brain Stimulation: What Changed?

The history of lobotomy shows the risks for limited evidence and oversight, while modern approaches emphasize targeted treatment, informed consent, and rigorous evaluation.

Wide Variation Seen in Lung Screening False-Positive Rates

US radiologists vary substantially in their reading of low-dose CT lung cancer screens, highlighting a need for measures to help standardize interpretation.

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Researchers compare first-line chemotherapy regimens in older patients with classical Hodgkin lymphoma to assess whether AVD is associated with better outcomes in routine care.

Do High-Risk Features of Prostate Cancer Boost HT Benefit?

Researchers analyze individual patient data from five randomized phase 3 trials comparing PORT alone vs PORT plus hormone therapy in patients with recurrent prostate cancer.

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A new real-world analysis helps clarify the most informative prognostic PSA benchmark in men with metastatic castration-sensitive prostate cancer.

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Living within 500 ft of a dry cleaner is linked to a 14% increased PD risk for vs living 4-5 miles away, with the strongest associations seen in certain US regions and in the gait-instability subtype.

Visual characteristics of lung disease are helping pulmonologists establish care plans and interventions.

A triple-combination therapy targeting the underlying defect in cystic fibrosis was associated with a dramatic reduction in antibiotic exposure among children and adolescents.

Recruitment freezes and lost rehab space are harming patient care, a CSP survey of 548 NHS physiotherapists finds.

A newly developed prognostic tool outperforms existing scoring systems in predicting short-term mortality risk following status epilepticus.

Dronabinol, a medication containing THC, is linked to fewer nightmares at lower intensity compared to placebo in patients with post-traumatic stress disorder, new data show.

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Vancomycin Prophylaxis Tied to Lower C difficile Recurrence

In children and young adults with cancer, oral vancomycin prophylaxis during broad-spectrum antibiotic therapy is associated with a lower risk for recurrent Clostridioides difficile infection.

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Spouses of individuals with dementia have a significantly higher risk of developing dementia, new research shows.

Romanian Healthcare Workers Strike Over Wage Bill Needed to Secure EU Funds

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The Restorative Power of ‘Sacred Moments’ in Medicine

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US FDA Approves Outlook Therapeutics' Eye Disease Drug

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Nasal IgA Protects Against H1N1, SARS-CoV-2 Infections

High baseline nasal IgA, not serum IgG, was linked to lower risk for influenza A H1N1 infection in a real-world study.

Punchlines and Pathology: The Secrets of Laughter Explained

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Gene Therapy Delivers Sustained Retinal Protection

People with age-related macular degeneration maintain vision and cut their need for supplemental injections by 90% 5 years after receiving gene therapy.

Online Harassment: Should Doctors Stay on Social Media?

Online harassment increasingly targets physicians who share evidence-based information, prompting calls for stronger institutional support and safer public engagement.

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The struggles advanced practice practitioners face are different than those that physicians deal with. But the threats are the same.

Ethical Conflict Common in Maternity Care

Providers who work as midwives, in both inpatient and outpatient settings, in southern US states, or who do not have kids may face the most ethical conflicts over drug testing and child welfare reporting.

Sugammadex Reduces Post-Op Lung Complications

Reversal of neuromuscular block with sugammadex reduces the risk for post-op pulmonary complications or death compared with neostigmine in older adults undergoing major abdominal or thoracic surgery.

Faricimab May Aid Hard-to-Treat Macular Degeneration Cases

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