Neoadjuvant immunotherapy improves outcomes in high-risk melanoma patients.

Published Date: 02 Mar 2023

High-risk melanoma patients who received the drug pembrolizumab before or after surgery to remove the cancer had a higher risk of developing melanoma than those who did not have a similar condition that eliminated cancer cells.

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Swimming plus education is more effective than education alone in reducing disability in adults with chronic low back pain over 8 weeks, a trial shows.

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Most children born premature with chronic lung disease have reversible airway obstruction, but bronchodilator responses vary widely, underscoring the need for individualized testing.

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Todays Updates

Residency Reverse: When the Patient's Home Is the Office

Home visits — once common and now resurging — flip the dynamic, as the clinician becomes a guest in the patient's home. Experts say as both learn more about each other than is possible in-office, trust can build.

Hidden Body Fat Threatens Male Fertility

Higher body fat percentage, rather than BMI, is associated with reduced sperm count and disrupted reproductive hormone levels in men.

The Dose Is Too High: Rethinking TKI Dosing

Standard TKI doses are often too high for long-term care. Dr Mark Kris shares his strategy for smart dose reductions that protect patient outcomes.

Optimizing Therapy in Early Stage HER2+ Breast Cancer

Cure rates are climbing, and so is the complexity of getting there. Dr Yara Abdou takes a closer look at optimizing HER2+ early-stage breast cancer therapy.

What I Wish I Knew Before Starting a Direct Primary Care

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Latest News

Romanian healthcare workers ended a nationwide strike on ⁠Friday as the country's caretaker government approved new hires in ⁠short-staffed state hospitals.

Swimming plus education is more effective than education alone in reducing disability in adults with chronic low back pain over 8 weeks, a trial shows.

Most children born premature with chronic lung disease have reversible airway obstruction, but bronchodilator responses vary widely, underscoring the need for individualized testing.

In children and young adults with cancer, oral vancomycin prophylaxis during broad-spectrum antibiotic therapy is associated with a lower risk for recurrent Clostridioides difficile infection.

Spouses of individuals with dementia have a significantly higher risk of developing dementia, new research shows.

Thousands of Romanian doctors, nurses and other health workers went on an indefinite strike ⁠for the first time in a decade on Tuesday, protesting job freezes and a public...

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Faricimab May Aid Hard-to-Treat Macular Degeneration Cases

Faricimab may stabilize vision, reduce retinal fluid and thickness, and cut treatment burden in difficult-to-treat cases of wet age-related macular degeneration.

Delays Harmless for Most Macular Degeneration Patients

Waiting for prior authorization of drugs affects a small portion of patients with age-related macular degeneration, resulting in vision loss.

Sri Lanka Uses Air Force Drones to Tackle Spreading Dengue Outbreak

Sri Lanka's public health services and hospitals are battling the worst outbreak of mosquito-borne dengue in nearly a decade, and turning to the island nation's armed...

A 3-Week Steroid Course Falls Short in Pneumonitis

In patients with mild immune-related pneumonitis, a shorter 3-week corticosteroid regimen does not meet noninferiority compared with the standard 6-week taper.

Cefazolin Noninferior to Penicillins for MSSA Bacteremia

Cefazolin is noninferior to antistaphylococcal penicillins for methicillin-susceptible Staphylococcus aureus bacteremia and is associated with a lower risk for acute kidney injury.

Tentacular Cyclosporiasis Outbreak Stymies Epidemiology Efforts

Confirmed case count across 34 states is five times the number reported last summer, the CDC says.

Transport Of Dead Bodies Within Congo Risks Further Ebola Spread, UN Agency Warns

The transport of Ebola victims' bodies between different areas of the Democratic Republic of Congo, often for funerals in their home communities, risks further ⁠spreading...

Noninvasive Ventilation May Lower Tracheostomy Need in BPD

In preemies with bronchopulmonary dysplasia on home respiratory support, noninvasive positive airway pressure is linked to shorter hospital stays and less healthcare use than tracheostomy ventilation.

Ensitrelvir Reduces COVID Risk Among Contacts Post-Exposure

Household contacts who initiate ensitrelvir vs placebo within 72 hours of symptom onset in the index patient have lower risk of developing COVID, with no apparent safety concerns.

Anemia Leads List of Factors That Affect BLVR Failure

Recognizing the impact of comorbidities may guide patient selection and improve outcomes.

How to Teach Professionalism? Ditch the Deficiency Focus

Teaching professionalism in medical school is required, but how best to do it? Move beyond a deficiency focus, experts say. Emphasize positive examples of professionalism.

Paid Parental Leave for Med School Faculty Often Lacking

Many medical schools don’t offer nationally recommended levels of paid parental leave.

Congo's Ebola Outbreak Spreads to Two More Provinces

The Ebola outbreak in the Democratic Republic of Congo has spread to two more northeastern provinces, Haut-Uele ⁠and Tshopo, the country's public health institute said in...

‘Super Movers’ May Have Slower Cognitive Decline

Fast-walking ‘super movers’ aged 80 years or older have about half the risk for cognitive impairment but no less Alzheimer’s disease pathology.

Sanofi to Stop Disparaging Rival Flu Vaccine to Stave Off EU Antitrust Fine

French pharmaceutical company Sanofi has offered to state publicly that ⁠a rival flu vaccine is as effective as its own, EU antitrust regulators said on Wednesday of the...

India's Dr Reddy's Says Semaglutide Shipping Disruption to Last Until At Least Late October

India's Dr Reddy's Laboratories said on Thursday that supplies of its generic semaglutide would remain unavailable in India and face disruptions in Canada until at least...

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