Four assays for measuring total and free PSA are accurate and consistent.

Published Date: 25 Apr 2023

A recent study compares the PSA levels found by four different prostate cancer screening assays.

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Latest News

Risk Assessment of Thyroid Nodules: A Practical Guide

Most thyroid nodules are benign, but risk stratification matters. Learn how ultrasound, TI-RADS, and postbiopsy tools guide smarter referral decisions.

A PCP’s Guide to Tangential Shave Biopsy

Learn how to perform a tangential shave biopsy with confidence. This step-by-step guide walks PCPs through the essential technique for sampling skin lesions and tumors.

Four Signs You Should Biopsy a Skin Lesion, Not Freeze It

Before you freeze a skin lesion, ask yourself whether you really know what it is. Here are four signs you should biopsy instead of freeze.

BRCA Testing Shifts From Late Data to Urgent Priority

BRCA testing now guides urgent treatment decisions as well as family risk assessment, and Spanish experts highlight its implications for PARP inhibitors, oncofertility, liquid biopsy, and exercise.

Wet Age-Related Macular Degeneration Updates From ASRS 2026

Updates in wet AMD from ASRS 2026 include real-world data on anti-VEGF treatment persistence, ELARA data on aflibercept 8 mg, as well as two studies showing reduced injection burden via gene therapy.

Stop Assuming Every Thick, Yellow Nail Is Fungus

Treating toenail fungus without confirming the diagnosis is a common mistake. Here's how to confirm it, treat it, and know what to expect.

Todays Updates

Many Clinical Paths Are Open to NPs. Here’s Help in Picking

‘A strength of the nurse practitioner profession is its versatility,’ one expert says.

Nurses Speak Out on Burnout, Mandatory Overtime, and Burning the Candle at Both Ends

Emotionally drained, sleep-deprived, and skipping meals to keep up: what nurse leaders say needs to change to prevent burnout.

Most Family Physicians Struggle With After-Hours Admin Work

Most family physicians face heavy administrative burden, but improved electronic health records and staff support may help to ease some of the load.

'Just Bloating': Stop Dismissing This Common GI Complaint

Bloating is one of patients' most common gastrointestinal complaints. Dr Alicia Muratore kicks off this six-part series by asking why bloating is often treated as an afterthought.

S1 Episode 4: Urinary Tract Infections and Sexual Function

Drs Anne Lenore Ackerman and Rachel S. Rubin discuss urinary tract infections, sexual function, quality of life, and the importance of patient education.

Immunotherapy Promises New Era in Cancer Prevention

Prof David Kerr explores whether PD-1 inhibitors and targeted vaccines can regress polyps and prevent secondary cancers in Lynch syndrome.

HF Hospitalizations and Telehealth Coverage Parity Laws

State telehealth coverage parity laws require private insurers to cover outpatient telehealth visits increasing access for HF patients. This analysis examines whether this affected clinical outcomes.

Todays Updates

Many Clinical Paths Are Open to NPs. Here’s Help in Picking

‘A strength of the nurse practitioner profession is its versatility,’ one expert says.

Nurses Speak Out on Burnout, Mandatory Overtime, and Burning the Candle at Both Ends

Emotionally drained, sleep-deprived, and skipping meals to keep up: what nurse leaders say needs to change to prevent burnout.

Most Family Physicians Struggle With After-Hours Admin Work

Most family physicians face heavy administrative burden, but improved electronic health records and staff support may help to ease some of the load.

'Just Bloating': Stop Dismissing This Common GI Complaint

Bloating is one of patients' most common gastrointestinal complaints. Dr Alicia Muratore kicks off this six-part series by asking why bloating is often treated as an afterthought.

S1 Episode 4: Urinary Tract Infections and Sexual Function

Drs Anne Lenore Ackerman and Rachel S. Rubin discuss urinary tract infections, sexual function, quality of life, and the importance of patient education.

Immunotherapy Promises New Era in Cancer Prevention

Prof David Kerr explores whether PD-1 inhibitors and targeted vaccines can regress polyps and prevent secondary cancers in Lynch syndrome.

HF Hospitalizations and Telehealth Coverage Parity Laws

State telehealth coverage parity laws require private insurers to cover outpatient telehealth visits increasing access for HF patients. This analysis examines whether this affected clinical outcomes.

Latest News

Most thyroid nodules are benign, but risk stratification matters. Learn how ultrasound, TI-RADS, and postbiopsy tools guide smarter referral decisions.

Learn how to perform a tangential shave biopsy with confidence. This step-by-step guide walks PCPs through the essential technique for sampling skin lesions and tumors.

Before you freeze a skin lesion, ask yourself whether you really know what it is. Here are four signs you should biopsy instead of freeze.

BRCA testing now guides urgent treatment decisions as well as family risk assessment, and Spanish experts highlight its implications for PARP inhibitors, oncofertility, liquid biopsy, and exercise.

Updates in wet AMD from ASRS 2026 include real-world data on anti-VEGF treatment persistence, ELARA data on aflibercept 8 mg, as well as two studies showing reduced injection burden via gene therapy.

Treating toenail fungus without confirming the diagnosis is a common mistake. Here's how to confirm it, treat it, and know what to expect.

News All Time

S1 Episode 6: Choosing Therapies for ATTR-CM in 2026

Drs Alexander and Urey walk through stabilizers vs silencers, pivotal trial data, and practical first line choices to help you select the right ATTR CM therapy for each patient.

Melanoma Clues Every PCP Should Know

A mole that stands out from the rest or keeps changing may be a warning sign. See how PCPs can use the ugly duckling sign and other clues in melanoma assessment.

Woman Develops Autoimmune/Inflammatory Syndrome After Filler

A woman develops autoimmune/inflammatory syndrome induced by adjuvants after hyaluronic acid filler and hyaluronidase exposure, with biopsy-confirmed acquired cutis laxa.

S1 Episode 3: Incidental Fatty Liver on Imaging: What Should You Do Next?

When fatty liver appears incidentally on imaging, "just lose weight" isn't enough. Dr Brandman explains how to use FIB-4, FibroScan, and ELF to triage who needs referral and who doesn't.

When to Worry About Pediatric Joint Pain

Which pediatric musculoskeletal complaints need an urgent workup? Dr Basco shares a systematic approach to identifying clinical red flags and serious pathology.

Fast Five Quiz: Presentation and Diagnosis of Psoriasis

How much do you know about the presentation and diagnosis of psoriasis? Test your knowledge with this quick quiz.

Skin Biopsy Essentials for Primary Care

Selecting the right biopsy technique is key to accurate diagnosis. Review practical guidance on shave and punch biopsies in primary care.

Pott’s Puffy Tumor in Teen Leads to Bilateral Blindness

A teen with Pott’s puffy tumor develops irreversible bilateral blindness after delayed diagnosis and intracranial complications, highlighting the importance of its early recognition.

Anti-Amyloids and Meaningful Change

Preventive neurologists Richard Isaacson and Jennifer Buczyner discuss the role of anti-amyloid drugs in patients with Alzheimer’s or mild cognitive impairment.

Can One Blood Test Detect 50 Cancers Early?

The latest evidence suggests multicancer early detection could expand screening beyond mammography and colonoscopy, yet key questions on outcomes and false positives remain.

A 5-Week-Old Male Presents With Blisters on His Right Leg

Examination revealed pink inflammatory papules and vesicles with areas of brown scale in a linear distribution extending from just above the right medial malleolus to the right inguinal crease.

Fever and Rash Reveal Japanese Spotted Fever in Woman

Recognizing fever, rash, and an eschar after tick exposure can support early diagnosis and timely antibiotic treatment, reducing the risk for severe complications.

Lost in Translation: Cancer Care's Coordination Problem

No shared records. No standard handoff. No common language. Three physicians break down why cancer care coordination keeps failing.

S3 Episode 5: The Future of Endometrial Cancer Pathology

Drs Ursula A. Matulonis and Marisa R. Nucci discuss the future of AI and pathology and how genetics and genomics play a role in the diagnosis of endometrial cancer.

What ASCO 2026 Taught Us About Scaling AI in Cancer Care

The next era of oncology AI won’t be won by the best model, the highest benchmarks, or flashiest press release. It will be won by the most reliable pathway to deployability.

Practice-Changing Data in GI Oncology

From ASCO 2026, Dr Mark Lewis breaks down a 'transformational' shift in GI oncology, from the historic RAS revolution to biomarker-driven advances in colon cancer.

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