Not all patients want faster cancer drug approvals without certainty they work

Published Date: 20 Nov 2024

Patients with cancer could be willing to wait for greater certainty of the benefit of new cancer drugs before they are approved by the U.S. Food and Drug Administration (FDA), suggests a new study from the London School of ...

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Chronic pain is a daily reality for millions of Americans, interfering with their everyday activities and quality of life. An estimated 24.3% of adults in the United States experienced chronic pain in 2023, and current treatment ...

A new study led by Yale's Jennifer Miller, Ph.D., found that medicines are not physically accessible in many of the countries where they are tested for FDA approval. The findings were published in JAMA Internal Medicine.

Animals survive in changing and unpredictable environments by not merely responding to new circumstances, but also, like humans, by forming inferences about their surroundings—for instance, squirrels understand that certain ...

Often dismissed as a minor ailment, migraine is a debilitating neurological disease affecting hundreds of thousands of New Zealanders. At the University of Otago's School of Biomedical Sciences, world-leading research by ...

Scientists think snakes and lizards could help them find new ways to prevent painful kidney stones and gout in people. And it all owes to an evolutionary trick.

The record-breaking federal government shutdown marked yet another impediment to scientific research efforts at the Wistar Institute this year.

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Slowed by sound: Mouse model of Parkinson's disease shows noise affects movement

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New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest ...

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A vaccine that tackles the bacteria that cause up to 200 million childhood infections every year could be possible, experts say.

Hundreds of animal studies on brain damage after stroke flagged for problematic images

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In drug trials, lack of oversight of research ethics boards could put Canadian patients at risk

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Discovery of 'doorstop' for brain's electrical gates may open path to new therapies for neurodegenerative conditions

As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At Cold Spring Harbor Laboratory (CSHL), scientists have turned their attention to the tiny pores that let charged ions ...

WHO's priorities shaped by its reliance on grants from donor organizations, study suggests

The World Health Organization's (WHO's) priorities are being skewed by its increasing reliance on donations from organizations such as the Gates Foundation (previously known as the Bill and Melinda Gates Foundation), which ...

Opt-out organ donation policies may reduce organ supply

Every day, 17 Americans die while waiting for an organ transplant. Opt-out organ donation policies, which enroll everyone into post-mortem donation programs by default unless people choose to opt out, have been touted as ...

New Hampshire man resumes dialysis after record 271 days living with a pig kidney

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Liver transplantation utilizing grafts donated after euthanasia is feasible, study suggests

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A 'bird's eye view' of how human brains operate

A new study provides the best evidence to date that the connection patterns between various parts of the human brain can tell scientists the specialized functions of each region.

Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor

Deciphering how the GR forms oligomers—through the binding of several subunits—opens a crucial avenue for developing more selective drugs. These new drugs could modulate this association and thus minimize serious adverse ...

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