Higher Crohn's disease rates with vedolizumab: a study

Published Date: 13 Mar 2023

The study results may prompt doctors to choose vedolizumab over anti-TNF therapy as the first-line treatment for Crohn's disease.

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The Intersection Between Gut and Spine Health

Emerging research is showing more and more connection between the two.

IBD Flare Prediction Improved by Psychosocial Data

Predictive models that combine patient-reported psychosocial measures with clinical data perform well in forecasting flares in patients with inflammatory bowel disease.

Sacral Fracture Risk After Short-Course RT for Rectal Cancer

A recent retrospective analysis assesses the incidence and risk factors for sacral fractures among patients receiving short-course radiation therapy for rectal cancer.

Heavy Drinking Tied to Young-Onset Pancreatic Cancer

A nationwide Korean cohort study of more than 6.2 million young adults found an association between heavy alcohol use and pancreatic cancer risk before age 50.

How Gut Bacteria Could Trigger Memory Loss as We Age

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Older adults with chronic disease who have less education, lower income, and no active jobs tend to experience symptoms of depression.

Infection Burden High With Myeloma T-Cell Therapies

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Weight-Based and Fixed-Dose Pembrolizumab Compared in NSCLC

A national cohort study compares the safety and efficacy of weight-based and fixed-dose pembrolizumab regimens in patients with advanced non-small cell lung cancer.

HER2 ADC Shows Promise in Recurrent Endometrial Cancer

Trastuzumab pamirtecan, a HER2-targeted antibody-drug conjugate, achieved ‘exceptional’ antitumor responses in patients with recurrent endometrial cancer, especially those with HER2 IHC 3+ tumors.

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Low Income, Education Tied to Depression in Older Adults

Older adults with chronic disease who have less education, lower income, and no active jobs tend to experience symptoms of depression.

Infection Burden High With Myeloma T-Cell Therapies

A retrospective study suggests a high burden of prolonged, mostly low-grade infections in patients with multiple myeloma who receive T-cell-engaging therapies.

Weight-Based and Fixed-Dose Pembrolizumab Compared in NSCLC

A national cohort study compares the safety and efficacy of weight-based and fixed-dose pembrolizumab regimens in patients with advanced non-small cell lung cancer.

HER2 ADC Shows Promise in Recurrent Endometrial Cancer

Trastuzumab pamirtecan, a HER2-targeted antibody-drug conjugate, achieved ‘exceptional’ antitumor responses in patients with recurrent endometrial cancer, especially those with HER2 IHC 3+ tumors.

Latest News

Emerging research is showing more and more connection between the two.

Predictive models that combine patient-reported psychosocial measures with clinical data perform well in forecasting flares in patients with inflammatory bowel disease.

A recent retrospective analysis assesses the incidence and risk factors for sacral fractures among patients receiving short-course radiation therapy for rectal cancer.

A nationwide Korean cohort study of more than 6.2 million young adults found an association between heavy alcohol use and pancreatic cancer risk before age 50.

Researchers found potential links between gut bacteria and memory loss, with gut-brain connections triggering loss of memory encoding in the hippocampus.

AstraZeneca said on Thursday that a combination treatment with its cancer drug Imfinzi showed significant improvement in ⁠how long patients with a common liver cancer lived...

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‘Failure to Thrive’ Now ‘Faltering Weight’ in Pediatrics

The World Health Organization also recommends using a z-score for diagnosing faltering weight, in addition to growth charts.

Tx Delays in CRC More Common in Urban Men, Racial Minorities

A study using data from Surveillance, Epidemiology, and End Results evaluates how sex, race, and geographic disparities affect treatment timeliness in patients with early-onset colorectal cancer.

From Royal Courts to Clinics: How Enemas Evolved

Once considered a universal remedy, enemas are now used selectively for specific clinical indications, such as bowel preparation.

Popular Caraway Oil for Dyspepsia: Benefit or Risk?

Caraway oil is widely used for digestive symptoms; however, strong clinical evidence supports its use in combination with peppermint oil for functional dyspepsia.

Duchenne Gene Therapy Shows Improved Muscle Function in Trial

Regenxbio said on Wednesday that interim data from a early-to-mid stage study of its experimental gene therapy ⁠in patients with Duchenne muscular dystrophy showed continued...

Early Top-Down Therapy Cuts Surgery Risk in Crohn’s

Five-year PROFILE follow-up shows early top-down infliximab-based therapy markedly reduces abdominal surgery and hospitalizations in Crohn’s vs step-up escalation.

Commercial Microbiome Tests: Unreliable Results

Study finds major methodological differences across seven direct-to-consumer stool tests, producing taxonomic profiles as variable as those between individuals — limiting clinical use.

Neoadjuvant GOLP Boosts Event-Free Survival in Liver Cancer

A phase 2/3 trial evaluates the efficacy and safety of neoadjuvant therapy with gemcitabine-oxaliplatin, lenvatinib, and toripalimab in patients with high-risk intrahepatic cholangiocarcinoma.

AI Beats Conventional Endoscopy in Neoplasm Detection

AI-assisted esophagogastroduodenoscopy is more effective than the conventional procedure in detecting upper GI neoplasms, particularly for lesions measuring ≤ 10 mm.

Global Study Supports Meat-Free Diets for Cancer Prevention

Observational data on more than 1.8 million people did yield surprises when it came to colorectal and esophageal cancers.

Healthy Midlife Diet Tied to Lower Risk of Cognitive Decline

Greater adherence to the DASH diet and other healthy eating patterns — especially in midlife — is linked to lower risk of cognitive decline later in life, three major US studies show.

CDC Vaccine Advisors to Consider COVID-19 Vaccine Injuries, Long COVID

The U.S. CDC's vaccine advisory committee will discuss and may vote on recommendations ⁠for issues including COVID-19 vaccine injuries and long COVID at its scheduled...

Risankizumab Effective in Crohn's, Real-World Data Show

Risankizumab is effective in inducing clinical and endoscopic remission and is generally well tolerated in patients with Crohn's disease, a real-world study shows.

Rifabutin Regimen Matches Bismuth Regimen in H pylori Rescue

Rifabutin-based triple regimen is noninferior to classical bismuth quadruple regimen as rescue treatment for Helicobacter pylori infection.

Italian Toddler Too Sick for Second Transplant, Doctors Say

An Italian toddler left clinging to life after receiving a damaged donor heart, is not well enough to undergo a second transplant, ⁠a panel of specialists ruled on Wednesday.

Guinea-Bissau Stops Vaccine Study Funded by Trump Administration

Guinea-Bissau's foreign minister has said his government has stopped a study funded by the Trump administration aiming to evaluate side effects of the life-saving hepatitis...

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