Maladaptive plasticity in spinal neurons mediated by Tiam1 has been found to be the cause of morphine tolerance.

Published Date: 10 Apr 2024

For the treatment of severe and chronic pain, morphine and other opioids are essential. Nevertheless, they have two drawbacks: long-term use leads to morphine tolerance, which paradoxically requires higher dosages to produce the same level of pain relief.

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