Maladaptive plasticity in spinal neurons mediated by Tiam1 has been found to be the cause of morphine tolerance.

Published Date: 10 Apr 2024

For the treatment of severe and chronic pain, morphine and other opioids are essential. Nevertheless, they have two drawbacks: long-term use leads to morphine tolerance, which paradoxically requires higher dosages to produce the same level of pain relief.

Read Full News

Latest News

Nurses Speak Out on Burnout, Mandatory Overtime, and Burning the Candle at Both Ends

Emotionally drained, sleep-deprived, and skipping meals to keep up: what nurse leaders say needs to change to prevent burnout.

Most Family Physicians Struggle With After-Hours Admin Work

Most family physicians face heavy administrative burden, but improved electronic health records and staff support may help to ease some of the load.

Lawsuit Against Bristol Myers Over Delayed Cancer Drug Is Revived

A U.S. federal appeals court said a judge erred in dismissing a $6.7 billion lawsuit accusing Bristol Myers Squibb of cheating former ⁠Celgene shareholders by delaying...

Residency Reverse: When the Patient's Home Is the Office

Home visits — once common and now resurging — flip the dynamic, as the clinician becomes a guest in the patient's home. Experts say as both learn more about each other than is possible in-office, trust can build.

Federal Agencies Widen Med School Admissions Investigations

Departments of Justice, Education accuse schools of making race-based decisions.

US Senate Panel Advances Trump CDC Pick Schwartz

The U.S. Senate health committee voted on Thursday to advance the nomination of President Donald Trump's pick for CDC director ⁠Dr. Erica Schwartz, handing his...

Todays Updates

Hyponatremia Risk Varies Among Second-Gen Antipsychotics

Aripiprazole is associated with a lower risk for hyponatremia compared with olanzapine in patients treated with second-generation antipsychotics, a new cohort study shows.

HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

Researchers evaluate changes in post-transplantation outcomes among patients with relapsed or refractory Hodgkin lymphoma from 2010 to 2022.

How Much of a Cancer Drug Is Too Much?

In a recent KFF survey, 43% of US adults said they had skipped their medication in the past year because of cost.

Todays Updates

Hyponatremia Risk Varies Among Second-Gen Antipsychotics

Aripiprazole is associated with a lower risk for hyponatremia compared with olanzapine in patients treated with second-generation antipsychotics, a new cohort study shows.

HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

Researchers evaluate changes in post-transplantation outcomes among patients with relapsed or refractory Hodgkin lymphoma from 2010 to 2022.

How Much of a Cancer Drug Is Too Much?

In a recent KFF survey, 43% of US adults said they had skipped their medication in the past year because of cost.

Latest News

Emotionally drained, sleep-deprived, and skipping meals to keep up: what nurse leaders say needs to change to prevent burnout.

Most family physicians face heavy administrative burden, but improved electronic health records and staff support may help to ease some of the load.

A U.S. federal appeals court said a judge erred in dismissing a $6.7 billion lawsuit accusing Bristol Myers Squibb of cheating former ⁠Celgene shareholders by delaying...

Home visits — once common and now resurging — flip the dynamic, as the clinician becomes a guest in the patient's home. Experts say as both learn more about each other than is possible in-office, trust can build.

Departments of Justice, Education accuse schools of making race-based decisions.

The U.S. Senate health committee voted on Thursday to advance the nomination of President Donald Trump's pick for CDC director ⁠Dr. Erica Schwartz, handing his...

News All Time

Analysis-Big Pharma Taps UK Playbook to Pressure European Capitals on Drug Prices

Global pharmaceutical companies, facing pushback from European capitals on drug pricing, are turning to a playbook that brought them recent success in Britain: threats of...

Studies Confirm Private Equity Dangers

A handful of studies confirm that hospitals taken over by private equity have worse outcomes for patients.

Cholera Outbreak in Nigeria's Borno Kills 74, Infects Thousands Since May

A cholera outbreak that began in early May in Nigeria's northeastern Borno state ⁠has killed at least 74 people and infected more than 7,800, overwhelming health facilities,...

Nurses Filling Doctor Gaps: What Happens to Hard Cases?

As health systems consider shifting more physician tasks to nurses, Medscape readers focused on whether expanded care models include clear supervision, escalation, and time for patients who do not fit routine protocols.

FDA Grants Emergency Approval for Over-the-counter Drug to Treat Screwworm in Pets

The U.S. Food and Drug Administration on Thursday authorized the emergency use of a generic over-the-counter tablet ⁠to treat infestations caused by the New World screwworm...

More Nurses are Clocking in to Second Jobs

More nurses regularly take on second shifts but as the practice becomes normalized, is this best for patients?

Sandoz Files European Complaint About Chinese Antibiotic Imports

Swiss generic drugmaker Sandoz filed a draft ⁠anti-dumping complaint with the European Commission over Chinese imports ⁠of the antibiotic ingredient amoxicillin.

What Your ZIP Code Is Costing You

Forget salary. The cities winning the physician satisfaction race are playing a completely different game.

How NPs Are Navigating Prior Authorization Coverage Barriers

The same hurdles facing physicians slow treatment for nurse practitioners’ patients, and the impact on care continues.

US FDA Issues Recall Of Boston Scientific Heart Devices

Boston Scientific has issued an urgent recall to correct several heart devices after ⁠the U.S. Food and Drug Administration classified the action as its most serious recall,...

Delays in Visa Program Threaten Hundreds of Doctors

Prolonged HHS J-1 waiver backlogs leave hundreds of foreign-trained doctors facing departure this summer, threatening care in underserved areas, immigration attorneys warn.

AstraZeneca to Invest $405 Million in Britain After US-UK Pharma Deal

Prime Minister Keir Starmer said on Wednesday that Britain's biggest company AstraZeneca would invest 300 million pounds ($405 ⁠million) in the country, after pausing...

Europe Risks Falling Behind in Medicine Race, Roche CEO

Europe risks falling behind the US and China in pharma innovation because of bureaucracy and government policies threatening ⁠jobs, Roche CEO Thomas Schinecker warns.

US Health Regulators to Speed Up Medicare Device Coverage

U.S. health regulators announced a new program to speed up Medicare coverage for certain medical devices on ⁠Thursday, saying it would cut reimbursement timelines to as...

Germany Risks Missing Out on New Drugs, AstraZeneca CEO Says

AstraZeneca's CEO said Germany risks missing out on new drugs that ⁠the drugmaker plans to launch if the nation sticks with plans to keep pharmaceutical spending in check.

U.S. to Ask States to Revalidate "high-risk" Medicaid Providers

Mehmet Oz, who heads the agency that runs the U.S. Medicare and ⁠Medicaid healthcare programs, said on Tuesday the Trump administration plans to ask all ⁠50 states to...

Recommended News For You

Severe obesity associated with reduced prevalence of recommended cancer screenings

In 18 States, alcohol exclusion laws are still in effect.

New Nanoparticles Can Destroy Undruggable Cancer Proteins

After a plane crash, a surgeon dies; Austin is released from the hospital; and an animal pandemic spreads.

Two medications might work better for breast cancers that are resistant to one.

Is a $2,000 Whole-Body MRI Worth It?

Scientists are investigating the prevention of recurrent breast cancer, which frequently results in death.

Recommended Articles For You

Innovative Methods in Oncology in the Digital Era 

Artificial Intelligence for Early Cancer Detection Leveraging Multi-Omics: A Comprehensive Review 

AI in the War on Cancer: How Digital Tools are Revolutionizing Oncology 

Living Better With Advanced Cancer Through Supportive Care 

Whats more on Hidoc Dr.

Medical Updates
KOL Videos
Surveys
Events

Daily news to keep you up to date

Gain valuable insights with our in-depth KOL Video discussions

Participate and win cash vouchers

Get updates on the latest events happening around the world
Featured News
Featured Articles
Featured Events
Featured KOL Videos

1.

Next Day Mood Is Affected by Ability to Recover From Work.

2.

Enhanced CAR T cell therapy offers new strategy for lymphoma

3.

With the use of a novel sequencing technique, pediatric bone marrow transplant mortality can be predicted by analyzing lung microbiomes.

4.

Decrease seen in in situ breast cancer since 2009

5.

Scientists hail the cervical cancer treatment as the most remarkable breakthrough in 20 years.

1.

Discovering the Benefits of TNK: A Comprehensive Blog Article 

2.

Rare Malignant Ovarian Tumors: A Comprehensive Review for Clinicians

3.

Revolutionizing Cancer Treatment with Darzalex: How an Innovative Drug is Transforming Lives

4.

Personalized Cancer Vaccines: The Next Frontier in Precision Oncology

5.

Precision Medicine and Genomics: Revolutionizing Healthcare Through Personalized Treatment

1.

Asian Symposium on Advancement in Hematology and Oncology (ASAHO)

2.

International Cancer Conference

3.

Asian Symposium on Advancement in Hematology and Oncology (ASAHO)

4.

Asian Symposium on Advancement in Hematology and Oncology

5.

Asian Symposium on Advancement in Hematology and Oncology

1.

Influence of CDK4/6 Inhibitors in Extending Progression-Free Survival (PFS) and Overall Survival in HR+/HER2- mBC Patients

2.

Pazopanib: A Game-Changer in Managing Advanced Renal Cell Carcinoma - Part II

3.

Managing ALK+ NSCLC while Ensuring Long-Term Safety of the Patients

4.

Dissecting Molecular differences between EGFR Exon 19 deletion and Exon 21 L858R Mutations

5.

The Reign of the CROWN Trial and the Dawn of a New Era in Frontline Management- Further Discussion

Fastest Growing Medical Platform for Doctors

Address :
Hidoc Dr. Inc. | Delaware C Corp | 1309 Coffeen Ave. Suite 1200, Sheridan WY, 82801

Phone :
+1-415-463-3094

Email :
anishagadia@hidoc.co

Quick Links

Drug DatabaseDrug InteractionDiseases Database
KOL VideosKnowledge HubQuizzes
Medical UpdatesEventsAbout Us

© Copyright 2026 Hidoc Dr. Inc.

Terms & Conditions - LLP | Inc. | Privacy Policy - LLP | Inc. | Account Deactivation
Home
Profile
Login
bot