Apr 18 2025 This Week in Cardiology

Published Date: 19 Apr 2025

The FAME 3 trial 5-year results, TAVR at 5 years, pacers after TAVR, and mavacamten not a wonder drug are the topics John Mandrola, MD, discusses in this week’s podcast.

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High-Dose Probiotic Helps Patients With Chronic Diarrhea

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3 Common Drugs Older Adults Might Be Overusing

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Standing Up More May Not Cut Risk for Cancer Death

Only replacing sitting with physical activity seems to help.

Todays Updates

Trappsol Cyclo Misses Primary End Point in Phase 3 Trial for Niemann-Pick Disease Type C Isabella Ciccone, MPH

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NeurologyLive® Friday 5 — October 2, 2026 Isabella Ciccone, MPH

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Todays Updates

Trappsol Cyclo Misses Primary End Point in Phase 3 Trial for Niemann-Pick Disease Type C Isabella Ciccone, MPH

Findings from the phase 3 TransportNPC study showed that Trappsol Cyclo missed the primary end point in Niemann-Pick type C, but subgroup and survival data support planned 2026 NDA.

NeurologyLive® Friday 5 — October 2, 2026 Isabella Ciccone, MPH

Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending October 2, 2026.

Latest News

Q3 2026 Preview: 4 FDA Decisions to Watch

FDA Grants Accelerated Approval to Navepegritide for Achondroplasia in Children Aged 2 Years and Older

Without nutrition and eating disorder support, clinicians prescribing GLP-1s may miss undernutrition, muscle loss, and harmful restriction.

A high-dose eight-strain probiotic is linked to a decrease in the percentage of fecal primary bile acids among patients with bile acid malabsorption.

Recent studies of three medications or classes of drugs widely used among older Americans illustrate the problem.

Only replacing sitting with physical activity seems to help.

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Reducing Infusion Wait Times at VA New Jersey

VA New Jersey slashed chemo infusion wait times 32% — from 164 to 106 minutes — through order templates, pre-visit bloodwork, and a fast-track room.

Evaluating the Implementation of 60-Minute Iron Infusions

Safe 60-minute iron dextran infusion protocol has been demonstrated at large institutions, but its impact on patient safety at small, rural clinics has not been reported.

Hospital Outcomes Associated With SUDs in Pancreatic Cancer

This project sought to evaluate the impact of substance use disorders on inpatient outcomes among hospitalized patients with pancreatic cancer.

Expanding CoC Standard 5.9

Smoking cessation improves treatment response and survival, while reducing recurrence and complications in cancer patients.

Cannabis Edibles Impair Driving Even Below Legal THC Limits

Cannabis edibles dose-dependently impair simulated driving performance hours after ingestion at THC blood concentrations below roadside enforcement levels.

Pollutant Exposure Tied to Increased Suicide Risk

Air pollutant exposure, especially to PM2.5, PM10, and nitrogen dioxide, is associated with increased risk for death by suicide, attempted suicide, and suicidal ideation.

Does Sex Factor in the Obstetrical Dilemma?

Baby boys tend to be larger at birth than girls. New research asks whether those differences may help explain more challenging deliveries.

SLE Linked to Increased Risk for Stroke

Patients with systemic lupus erythematosus face a substantially elevated risk for ischemic and hemorrhagic stroke compared with control individuals, a meta-analysis shows.

Shingles Vaccine Boosts Antibodies in People Living With HIV

A recombinant zoster vaccine builds strong antibody protection in people living with HIV, regardless of their CD4 count — but their cellular immune response still lags behind those without HIV.

Remote Videos Can Reliably Flag Cerebral Palsy Risk

Remote video-based assessment at 3-4 months of corrected age can reliably flag the risk for cerebral palsy in infants born very preterm.

Primary Care Quality Tied to Hospital Use in Multimorbidity

In patients with multimorbidity, better primary care checks increase the odds of outpatient and emergency care, but multimorbidity-specific checks lower the odds of elective hospital admissions.

AI in Gastroenterology: Benefits vs Harms

AI applications are poised to become the mandated standard of practice in gastroenterology, and in some institutions already are.

Esophagitis Dissecans Superficialis in Woman With Dysphagia

A woman presents with progressive dysphagia and vomiting; endoscopy reveals extensive esophageal mucosal sloughing consistent with esophagitis dissecans superficialis.

Laughter Really Is The Best Medicine

The data on laughter are more serious than you’d expect. Dr Neil Skolnik breaks down the physiological benefits of humor.

AI in Medicine Reduces Burden, Not Judgment

AI in medicine isn’t about replacing clinical reasoning. It’s about freeing up physicians to do more of what only they can do.

Gaps in Access to Maternity Care Tied to Labor Induction

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