Deep Dive: CGRP Therapies: First-Line Status, New Safety Signal

Published Date: 18 Jul 2026

Now first-line per AHS, CGRP therapies also carry a growing Raynaud phenomenon signal, says Shaheen Lakhan, MD. A guide to choosing among all 8 approved agents.

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Hip Fracture, No Surgery? Phenol Block May Help Older Adults

Injecting phenol into the nerve group surrounding the hip capsule may offer some pain relief and mobility gains in older adults who are frail and forgo surgery for hip fracture.

Coma Therapy Tied to Poor Outcomes in Nonconvulsive SE

Patients with nonconvulsive status epilepticus treated with therapeutic coma experience markedly higher rates of complications and mortality than those not receiving the treatment.

Whole Person Approach to Pain Management for Vets in Hospice

This quality improvement project aims to support the uptake and utilization of nonpharmacological pain management interventions for veterans receiving inpatient hospice care.

Axial PsA Diagnosis: Applying AXIS Evidence in Practice

Dr Denis Poddubnyy discusses data from the AXIS study that inform his approach to diagnosing axial psoriatic arthritis.

Doc Sues Malpractice Insurer for Refusing to Settle Lawsuit

A South Carolina ob/gyn says MagMutual should have settled a patient’s malpractice lawsuit after a birth injury.

Cancer Pain Remains a Major Clinical Challenge

From nerve blocks to intrathecal systems, specialists say advanced pain strategies may help when standard analgesics fall short.

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UK Lawmakers Reject Bid to Legalise Assisted Dying

British lawmakers rejected on Friday a proposal to legalise assisted dying for terminally ill people, dealing a major setback to campaigners and bringing the latest effort...

Liberalized Cannabis Policies May Increase Substance Use

In a global review, legalization was associated with increased cannabis use and related emergency department visits, with potential decreases in the use of alcohol and tobacco.

Tissue-Free ctDNA Predicts Recurrence in Early Breast Cancer

Researchers analyzed plasma samples collected from 313 patients with early breast cancer approximately 2 years after they had completed adjuvant chemotherapy.

Can Response-Adapted Surgery Improve Outcomes in HNSCC?

Patients who respond to neoadjuvant immunochemotherapy may be able to undergo less extensive surgery, with high rates of disease control and organ preservation.

TKI Discontinuation Feasible After ALL Treatment

In patients with first- or second-line Philadelphia-positive B-cell acute lymphoblastic leukemia, favorable outcomes are observed with discontinuation of ponatinib.

SBRT Plus Atezolizumab Shows No Benefit in Inoperable NSCLC

For patients with early-stage, inoperable lung cancer, adding atezolizumab to standard radiotherapy boosts toxicity, not survival.

Todays Updates

UK Lawmakers Reject Bid to Legalise Assisted Dying

British lawmakers rejected on Friday a proposal to legalise assisted dying for terminally ill people, dealing a major setback to campaigners and bringing the latest effort...

Liberalized Cannabis Policies May Increase Substance Use

In a global review, legalization was associated with increased cannabis use and related emergency department visits, with potential decreases in the use of alcohol and tobacco.

Tissue-Free ctDNA Predicts Recurrence in Early Breast Cancer

Researchers analyzed plasma samples collected from 313 patients with early breast cancer approximately 2 years after they had completed adjuvant chemotherapy.

Can Response-Adapted Surgery Improve Outcomes in HNSCC?

Patients who respond to neoadjuvant immunochemotherapy may be able to undergo less extensive surgery, with high rates of disease control and organ preservation.

TKI Discontinuation Feasible After ALL Treatment

In patients with first- or second-line Philadelphia-positive B-cell acute lymphoblastic leukemia, favorable outcomes are observed with discontinuation of ponatinib.

SBRT Plus Atezolizumab Shows No Benefit in Inoperable NSCLC

For patients with early-stage, inoperable lung cancer, adding atezolizumab to standard radiotherapy boosts toxicity, not survival.

Latest News

Injecting phenol into the nerve group surrounding the hip capsule may offer some pain relief and mobility gains in older adults who are frail and forgo surgery for hip fracture.

Patients with nonconvulsive status epilepticus treated with therapeutic coma experience markedly higher rates of complications and mortality than those not receiving the treatment.

This quality improvement project aims to support the uptake and utilization of nonpharmacological pain management interventions for veterans receiving inpatient hospice care.

Dr Denis Poddubnyy discusses data from the AXIS study that inform his approach to diagnosing axial psoriatic arthritis.

A South Carolina ob/gyn says MagMutual should have settled a patient’s malpractice lawsuit after a birth injury.

From nerve blocks to intrathecal systems, specialists say advanced pain strategies may help when standard analgesics fall short.

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‘No Cure’: What This Doctor Did When Her Own Health Imploded

She always wanted to be a strong doctor, but everything changed when this anesthesiologist realized the truth about her rare symptoms — and incurable condition.

Booming Weight-loss Drug Demand in Brazil Fuels Thriving Black Market and Health Fears

When Brazilian customs agents opened jars of dulce de leche aboard a tourist bus arriving from Paraguay in April, they discovered hundreds of vials of tirzepatide, the...

Watch Out! A Coding Audit May Be Coming Your Way

Payers are stepping up their audit activities for medical practice and hospital billing and coding. Here’s how to avoid being a target.

How Scrubs (and Time) Quietly Stole the White Coat’s Mojo

They began as plain operating-room clothes. Now scrubs are healthcare’s default uniform, a big business, and even runway inspiration. How did the white coat go out of style?

Beyond the Scale: Men Turn to Cosmetic Clinics to Complete Weight-loss Transformation

As top-selling weight-loss drugs help more U.S. men slim down, a growing number are seeking cosmetic treatments for sagging skin, hair loss and dental issues to complete...

Deep Dive: SNRIs: One Mechanism, No Interchangeability

Milnacipran and its enantiomer, levomilnacipran, share a mechanism but not one approved indication. Alan Schatzberg, MD, on what that split means for prescribing.

States Tighten Private Equity Healthcare Oversight

Nearly a dozen states have recently enacted laws addressing private equity in healthcare, including ownership transparency and physician control, with more bills pending.

Mental Health Burden High Among PWH in Panama

Nearly 1 in 6 people living with HIV report moderate-to-severe depression and nearly 1 in 5 report high anxiety — both tied to discrimination, chronic pain, and difficulty with daily activities.

Are GLP-1 Drugs Now Kidney Drugs?

We file GLP-1s under "diabetes drugs" or "weight-loss drugs." Both labels are true. But data from the last 24 months show that these are kidney drugs.

Rewriting the Vaccine Schedule Without Science at the Table

Dr Daskalakis explains the confusion a recent executive order on vaccines can wrought, and why the MMR vaccine cannot simply be split into three shots.

How to Discuss Postmastectomy Numbness in a 20-Minute Visit

Dr Kristin Rojas gives clinicians practical and actionable tips on how to discuss postmastectomy numbness and intimacy with patients.

Is Chronic Pain Guidance Delivering What NICE Promised?

Pain specialists say patients still aren’t getting what NICE’s guidance promised — and access remains the real barrier.

Deep Dive: DOACs in 2026: Why the Incumbents Still Win

Two trials tried to beat DOACs on bleeding. One (phase 3) failed on efficacy; the other (phase 2b) left stroke prevention unproven. John Alexander, MD, on what that means for practice.

GLP-1s and Blinding Condition; Cyclosporiasis Source Found? Tylenol-Autism Lawsuits

Health news and commentary gathered by MedPage Today staff

Study Offers Reassurance to Women Considering Epidural During Labor

The BMJ offers more information on its effect in neonates

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Clinical trial turns up small difference in scores but can't make definitive conclusions

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