Confirmed Antitumor Activity with T-DXd for HER2-Positive Metastatic CRC

Published Date: 20 Aug 2024

Overall response rate approaching 40%, including hard-to-treat RAS-mutant tumors

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Is the Combination of GLP-1s and Clozapine Safe?

Gastrointestinal hypomotility is the most lethal adverse event linked to clozapine use. GLP-1s slow the gut too. Clinicians are combining the two, with little safety data to guide them.

Health Round: Experimental Blood Test Finds High-risk Colorectal Lesions Before Cancer Develops

We also report on a flavoring chemical in e-cigarettes that damages human embryo cells in lab experiments.

Constipation Relief: Elobixibat Outperforms Prucalopride

Elobixibat offers faster and greater symptomatic relief than prucalopride among patients with functional constipation unresponsive to first-line treatment.

Pancreatic Cysts: Sparing Use of Invasive Tests Seems Safe

Guidelines call for strict limits on invasive tests for pancreatic cyst surveillance, and a new study supports the strategy’s safety.

Patients’ Wait Times for Cancer Surgeries Keep Growing

Wait times for potentially curative cancer surgery, which have been climbing steadily for more than a decade, have risen particularly rapidly at high-volume academic centers.

Taylor Farms Outbreaks Show Limits Of US Ability to Safeguard Produce From Mexico

Two foodborne illness outbreaks linked to Taylor Farms have exposed a weakness at the heart of North America's food system: the United States is increasingly relying on...

Todays Updates

Belgian Algorithm Reshapes Endometrial Cancer Care

A new Belgian algorithm may help clinicians choose adjuvant therapy more precisely in early endometrial cancer, moving beyond TNM staging alone.

Todays Updates

Belgian Algorithm Reshapes Endometrial Cancer Care

A new Belgian algorithm may help clinicians choose adjuvant therapy more precisely in early endometrial cancer, moving beyond TNM staging alone.

Latest News

Gastrointestinal hypomotility is the most lethal adverse event linked to clozapine use. GLP-1s slow the gut too. Clinicians are combining the two, with little safety data to guide them.

We also report on a flavoring chemical in e-cigarettes that damages human embryo cells in lab experiments.

Elobixibat offers faster and greater symptomatic relief than prucalopride among patients with functional constipation unresponsive to first-line treatment.

Guidelines call for strict limits on invasive tests for pancreatic cyst surveillance, and a new study supports the strategy’s safety.

Wait times for potentially curative cancer surgery, which have been climbing steadily for more than a decade, have risen particularly rapidly at high-volume academic centers.

Two foodborne illness outbreaks linked to Taylor Farms have exposed a weakness at the heart of North America's food system: the United States is increasingly relying on...

News All Time

Mexican Jalapenos Tied to Salmonella Outbreak in 27 US States

U.S. health officials are investigating a Salmonella outbreak linked to Mexican jalapeno peppers that has sickened 345 people in 27 states, prompting supplier ⁠Coast Citrus...

US Cyclosporiasis Probe Linked to Lettuce Widens to 15 States

U.S. health authorities have widened their probe into a cyclosporiasis outbreak tied to iceberg lettuce from central Mexico after detecting cases in six additional states,...

Genetic Marker Linked to Severe Outcomes Across IBD Subtypes

HLA-DRB1*01:03 may serve as a genetic marker for severe outcomes across IBD phenotypes and help identify patients at higher risks for surgery and treatment failure.

Does High-Dose Vitamin D3 Supplementation Improve CRC Survival?

A phase 3 trial was conducted to confirm the benefit of high-dose vitamin D3 supplementation in patients with previously untreated metastatic CRC that was seen in a phase 2 trial.

Small Colorectal Lesions Carry Risk for Deep Invasion

Non-pedunculated colorectal lesions smaller than 2 cm may harbor deep submucosal invasion despite their diminutive size, study finds.

IV Vitamin C With Chemo Shows Signals in Cancer Care

A phase 2 study reported a longer median overall survival in patients receiving IV ascorbate with chemotherapy, although larger randomized trials are needed to confirm the finding.

Etrasimod Effective As First-Line Advanced UC Therapy

Etrasimod can be an effective and safe first-line advanced therapy option in patients with ulcerative colitis who escalate after conventional treatment failure.

Does Doublet Chemotherapy Improve Survival in Rectal Cancer?

Patients with high-risk locally advanced rectal cancer were randomly assigned to receive doublet-LC TNT or conventional neoadjuvant chemoradiotherapy.

Radiation Boost Linked to Better Survival in Rectal Cancer

A phase 2 trial finds that adding a modest radiation boost improves 9-year survival without increasing toxicity, despite no improvement in pathologic complete response.

Creatinine Assay Bias Affects MELD Scoring

Bilirubin interference in commonly used creatinine assays artificially inflates MELD scores in liver transplant candidates, a study reports.

EHR Marker May Help Curb Risk for Liver Transplant Rejection

A remote intervention aimed at improving medication adherence may reduce organ rejection in liver transplant recipients at high risk.

Altimmune Drug Cuts Heavy Drinking in Mid-stage Trial for Alcohol Use Disorder

Altimmune said on Tuesday its experimental drug helped patients with alcohol use disorder cut back on heavy drinking ⁠in a mid-stage trial, sending the company's shares 10%...

Newer Antibiotics Show No Clear Benefit for Staph Infections

A new meta-analysis finds ceftaroline and ceftobiprole monotherapy show no clear advantage over standard therapy for non-urinary Staphylococcus aureus infections.

FDA Approves Freenome's Blood Test for Colorectal Cancer Screening

The U.S. FDA has approved Freenome's blood-based colorectal cancer screening test for older adults, paving the way ⁠for partner Abbott to launch it in the U.S. this fall,...

Company At Center Of US Cyclospora Outbreak Complained to White House, Source Says

U.S. produce supplier Taylor Farms complained to White House and Food and Drug Administration officials about the government's inspection process earlier this month, a...

Poultry Firm Recalls Nearly 1.6 Million Dozen Eggs Over Salmonella Risk, FDA Says

The U.S. FDA said on Wednesday that Midwest Poultry Services is recalling nearly 1.6 ⁠million dozen eggs produced in Texas due to potential Salmonella...

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