Today's Updates

5 Rheumatology Headlines You Missed in December 2025 Victoria Johnson
Published Date: 17 Jan 2026

This rheumatology month in review emphasizes new data and impactful approvals.

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Q4 2025 Recap: Rheumatology News and Updates Victoria Johnson
Published Date: 17 Jan 2026

The Q4 recap for rheumatology spotlights regulatory and clinical advances across rheumatic diseases.

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Exploring Depressive Symptoms in Low-IQ Youth with Refractory Epilepsy Janelle L Wagner, PhD, Shannon Brothers, PhD, Cortney Wolfe-Christensen, PhD, Louie Pasculli
Published Date: 17 Jan 2026

A trio of clinician authors provided insights on a recently published paper assessing youths with refractory epilepsy and ways to combat depressive symptoms.

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FDA Approves Subcutaneous Copper Histidinate as First Treatment for Pediatric Menkes Disease Isabella Ciccone, MPH
Published Date: 17 Jan 2026

The FDA approved Sentynl Therapeutics’ copper histidinate for the treatment of pediatric Menkes disease, a rare genetic neurodegenerative disorder, following an earlier complete response letter.

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Rituximab Displays Long-Term Effectiveness for Relapsing MS Louie Pasculli
Published Date: 17 Jan 2026

Annette Lenger-Gould, MD, PhD, lead for clinical and translational neuroscience at Kaiser Permanente, discusses findings and significance from a recently published trial assessing rituximab in patients with relapsing multiple sclerosis.

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NeuroVoices: Nicholas Ashton, PhD, on Advances and Challenges in Alzheimer Disease Biomarkers Nicholas Ashton, PhD, Isabella Ciccone, MPH
Published Date: 17 Jan 2026

The senior director of the Fluid Biomarker Program at Banner Health highlighted the evolving role of blood and fluid biomarkers in Alzheimer disease research and clinical practice.

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High-Dose Nusinersen Gains European Commission Approval for Spinal Muscular Atrophy Louie Pasculli
Published Date: 17 Jan 2026

The European Commission approved Biogen’s high-dose nusinersen regimen for 5q SMA, supported by DEVOTE trial data showing significantly improved motor function with a safety profile consistent with the standard-dose regimen.

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Patients Treated With REGENXBIO’s DMD Gene Therapy RGX-202 Exceed Expected Disease Trajectory on NSAA Noah Stansfield
Published Date: 17 Jan 2026

In the middle of 2026, the company is planning to submit a BLA for RGX-202 via an accelerated approval pathway.

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Stereotactic Radiosurgery: Advancing Precision in Treating Neurological Disorders Lilyana Angelov, MD
Published Date: 17 Jan 2026

The director of Cleveland Clinic's Gamme Knife Center and Head Section of Spine Tumors writes about how stereotactic radiosurgery has transformed modern neurology and neurosurgery

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Stopping Inhaled Corticosteroids or LAMA in COPD Linked to Early Exacerbations
Published Date: 17 Jan 2026

Stopping Inhaled Corticosteroids or LAMA in COPD Linked to Early Exacerbations

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From GOLD to Ground Level: Navigating Biologic Use in COPD Care
Published Date: 17 Jan 2026

From GOLD to Ground Level: Navigating Biologic Use in COPD Care

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FDA Approves ProlivRx, First At-Home Neuromodulation Device for MDD
Published Date: 17 Jan 2026

FDA Approves ProlivRx, First At-Home Neuromodulation Device for MDD

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Gentamicin May Not Reduce Post Kidney Transplant Urinary Tract Infection Risk
Published Date: 17 Jan 2026

Gentamicin May Not Reduce Post Kidney Transplant Urinary Tract Infection Risk

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New MERD Risk Score Predicts Mortality for Kidney Transplant Waitlist Patients
Published Date: 17 Jan 2026

New MERD Risk Score Predicts Mortality for Kidney Transplant Waitlist Patients

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Younger Adults Face Pronounced Racial, Ethnic Gaps in Kidney Therapy
Published Date: 17 Jan 2026

Younger Adults Face Pronounced Racial, Ethnic Gaps in Kidney Therapy

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Age, Sex Specific eGFR Percentiles May Enable Earlier CKD Detection
Published Date: 17 Jan 2026

Age, Sex Specific eGFR Percentiles May Enable Earlier CKD Detection

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ICP-332 Effective, Safe for Treating Moderate to Severe Atopic Dermatitis
Published Date: 17 Jan 2026

ICP-332 Effective, Safe for Treating Moderate to Severe Atopic Dermatitis

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Ritlecitinib Efficacious for Non-Segmental Vitiligo Across Various Subgroups
Published Date: 17 Jan 2026

Ritlecitinib Efficacious for Non-Segmental Vitiligo Across Various Subgroups

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Digital Eczema Education Decreases Relapse Rates in Children in the Short-Term
Published Date: 17 Jan 2026

Digital Eczema Education Decreases Relapse Rates in Children in the Short-Term

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Unmet Needs Highlighted Regarding CSU Treatment Escalation
Published Date: 17 Jan 2026

Unmet Needs Highlighted Regarding CSU Treatment Escalation

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Latest News

Molecule that could cause COVID clotting key to new treatments

In a surprising discovery, a "sticky molecule" that occurs naturally in our blood vessels could be both a culprit behind blood clots and organ failure during COVID and long COVID and the key to new treatments to counter COVID-related ...

New potential gene-based treatment for sepsis and lung injury

A new discovery from the lab of YouYang Zhao, Ph.D., from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, opens promising new directions for treatment of life-threatening ...

DNA methylation patterns in newborns point to susceptibility to schizophrenia

Genetic susceptibility to neurodevelopmental conditions such as schizophrenia, autism, and ADHD can be linked, in part, to distinct epigenetic signatures in newborn cord blood. An analysis of nearly 6,000 newborns published ...

CRISPR breakthrough reverses chemotherapy resistance in lung cancer

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach ...

Fertility treatments linked to higher mutations than natural conception in mice

Mice pups conceived with in vitro fertilization (IVF) in the lab have slightly increased rates of DNA errors, or mutations, compared to pups conceived naturally, a new study on artificial reproductive technologies suggests.

A time-sensitive genetic switch for sex-specific features of developing neurons

Researchers have identified that the precisely timed transcription of two genes named grim and reaper is responsible for the targeted death of neurons within the developing nervous system of female flies. This group of neurons ...

New genetic test targets elusive cause of rare movement disorder

Scientists at Brigham and Women's Hospital and Harvard Medical School have developed a targeted genetic test to improve diagnosis for X-linked dystonia-parkinsonism (XDP), a rare and disabling movement disorder that affects ...

Q&A: Identifying new risk genes for schizophrenia

Schizophrenia, a psychiatric disorder that affects how a person feels, thinks, and behaves, affects roughly 1% of the population (approximately 3.5 million people in the U.S.) and is a leading cause of disability and death. ...

Genetic tool reveals chromosome changes linked to pregnancy loss

Pregnancy loss may occur in as many as 25% of all pregnancies. Most of these losses occur in the first trimester, and about half are caused by genetic or chromosomal issues.

Changes in a single gene can cause mental illness, study reveals

Until now, researchers assumed that schizophrenia, anxiety disorders or depression arise from an interplay of many different factors, including genetic ones.

Researchers reveal intricate control system for key immune gene

The immune system faces a delicate balancing act: It must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues.

Genes may predict suicide risk in depression

Depression in young adulthood has a stronger hereditary component and is associated with a higher risk of suicide attempts than depression that begins later in life, according to a new study published in Nature Genetics by ...

AI helps better understand how genetic mutations affect our health

As language models learn to interpret words in a sentence, protein language models learn how amino acids work together within a protein.

Brain tumor patients miss out on new treatments due to unequal access to tumor freezing and genetic testing, study warns

Molecular and genetic testing has become a game-changer in brain tumor care—shaping diagnosis, guiding treatments and opening doors to new therapies. Once available to a handful of patients, these tests are now rapidly ...

Decade-long genome study reveals best practices for managing large DNA databases

At a time when large-scale human genome analysis was not yet common, the Tohoku Medical Megabank Organization (ToMMo) launched its genome cohort study. After 10 years of operating this ambitious project, they are sharing ...

Surprising blood stem cell diversification revealed in humans

Every second, millions of blood cells are produced in the human body, and about 90% of the cells replaced daily are blood cells. These include red blood cells essential for oxygen transport, platelets for blood clotting, ...

Latest News

Molecule that could cause COVID clotting key to new treatments

In a surprising discovery, a "sticky molecule" that occurs naturally in our blood vessels could be both a culprit behind blood clots and organ failure during COVID and long COVID and the key to new treatments to counter COVID-related ...

New potential gene-based treatment for sepsis and lung injury

A new discovery from the lab of YouYang Zhao, Ph.D., from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, opens promising new directions for treatment of life-threatening ...

DNA methylation patterns in newborns point to susceptibility to schizophrenia

Genetic susceptibility to neurodevelopmental conditions such as schizophrenia, autism, and ADHD can be linked, in part, to distinct epigenetic signatures in newborn cord blood. An analysis of nearly 6,000 newborns published ...

CRISPR breakthrough reverses chemotherapy resistance in lung cancer

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach ...

Fertility treatments linked to higher mutations than natural conception in mice

Mice pups conceived with in vitro fertilization (IVF) in the lab have slightly increased rates of DNA errors, or mutations, compared to pups conceived naturally, a new study on artificial reproductive technologies suggests.

A time-sensitive genetic switch for sex-specific features of developing neurons

Researchers have identified that the precisely timed transcription of two genes named grim and reaper is responsible for the targeted death of neurons within the developing nervous system of female flies. This group of neurons ...

New genetic test targets elusive cause of rare movement disorder

Scientists at Brigham and Women's Hospital and Harvard Medical School have developed a targeted genetic test to improve diagnosis for X-linked dystonia-parkinsonism (XDP), a rare and disabling movement disorder that affects ...

Q&A: Identifying new risk genes for schizophrenia

Schizophrenia, a psychiatric disorder that affects how a person feels, thinks, and behaves, affects roughly 1% of the population (approximately 3.5 million people in the U.S.) and is a leading cause of disability and death. ...

Genetic tool reveals chromosome changes linked to pregnancy loss

Pregnancy loss may occur in as many as 25% of all pregnancies. Most of these losses occur in the first trimester, and about half are caused by genetic or chromosomal issues.

Changes in a single gene can cause mental illness, study reveals

Until now, researchers assumed that schizophrenia, anxiety disorders or depression arise from an interplay of many different factors, including genetic ones.

Researchers reveal intricate control system for key immune gene

The immune system faces a delicate balancing act: It must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues.

Genes may predict suicide risk in depression

Depression in young adulthood has a stronger hereditary component and is associated with a higher risk of suicide attempts than depression that begins later in life, according to a new study published in Nature Genetics by ...

AI helps better understand how genetic mutations affect our health

As language models learn to interpret words in a sentence, protein language models learn how amino acids work together within a protein.

Brain tumor patients miss out on new treatments due to unequal access to tumor freezing and genetic testing, study warns

Molecular and genetic testing has become a game-changer in brain tumor care—shaping diagnosis, guiding treatments and opening doors to new therapies. Once available to a handful of patients, these tests are now rapidly ...

Decade-long genome study reveals best practices for managing large DNA databases

At a time when large-scale human genome analysis was not yet common, the Tohoku Medical Megabank Organization (ToMMo) launched its genome cohort study. After 10 years of operating this ambitious project, they are sharing ...

Surprising blood stem cell diversification revealed in humans

Every second, millions of blood cells are produced in the human body, and about 90% of the cells replaced daily are blood cells. These include red blood cells essential for oxygen transport, platelets for blood clotting, ...

News All Time

Surprising blood stem cell diversification revealed in humans

Every second, millions of blood cells are produced in the human body, and about 90% of the cells replaced daily are blood cells. These include red blood cells essential for oxygen transport, platelets for blood clotting, ...

Q&A: Research offers hope for new autoimmune treatments

Alec Whited ('25 MS, Biology) is helping uncover how cells remove waste, a process that could lead to better treatments for autoimmune diseases and improved wound healing.

Tracking RNA levels reveals new clues in triple-negative breast cancer progression

When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer's development or ...

New clinical practice resource on managing RAD51C, RAD51D, and BRIP1 variants released

The American College of Medical Genetics and Genomics (ACMG) has published a new clinical practice resource, "Management of Individuals with Heterozygous Germline Pathogenic Variants in RAD51C, RAD51D, and BRIP1: A clinical ...

Should kids be screened for high cholesterol genes? Study weighs costs and benefits

In the United States, 1 in every 250 people has inherited a genetic variant that leads to dangerously high cholesterol levels from birth.

James Watson helped crack DNA's code, sparking medical advances and ethical debates

On a foggy Saturday morning in 1953, a tall, skinny 24-year-old man fiddled with shapes he had cut out of cardboard. They represented fragments of a DNA molecule, and young James Watson was trying to figure how they fit together ...

Breast cancer relapse: Key cellular resistance mechanism discovered

Triple-negative breast cancer is one of the most aggressive and difficult cancers to treat. It can initially respond well to therapeutic combinations of chemotherapy, but a tiny minority of tumor cells may manage to tolerate ...

Genetically altered hair cells show how inner ear structures are organized

Northwestern Medicine scientists have uncovered how a specific type of cell in the inner ear plays a commanding role in shaping the cellular landscape of the organ responsible for hearing, according to a study published in ...

Key histone variant may explain some forms of infertility

An epigenetic factor that is essential for producing mature egg cells in mice has been identified by RIKEN researchers for the first time. This discovery could aid research into cases of infertility caused by immature eggs.

Hundreds of genes act differently in the brains of men and women

Differences between men and women in intelligence and behavior have been proposed and disputed for decades.

CRISPR screen identifies new regulator of androgen receptor in prostate cancer

A poorly characterized protein, historically thought to be a chaperon or enzyme, may actually be a key player in prostate cancer. In a systematic CRISPR screen, scientists from Arc Institute, UCSF, and the Fred Hutchinson ...

Study identifies key genes linked to aggressive prostate cancer in people of African descent

New prostate cancer research from an international team led by the Center for Genetic Epidemiology at the Keck School of Medicine of USC has yielded discoveries that could improve screening and treatment for patients of African ...

Experimental drug blocks key protein to trigger cancer cell self-destruction in lung tumors

NYU Langone Health researchers found that a type of cell death caused by a buildup of highly reactive molecules suppresses lung tumor growth.

Bowel cancer's 'Big bang': How a crucial moment determines future growth

Like the astronomical explosion that kickstarted the universe, bowel cancer has a "Big Bang" moment which determines how it will grow, according to new research.

DNA discovery could help identify mothers at risk of pre-eclampsia

The human genome is riddled with relics of viral infections—bits of DNA from viruses that have been inserted in human DNA over millions of years and never left. Most are silent but some have taken on functional roles, particularly ...

Hidden nuclear droplets link multiple leukemias and reveal a new therapeutic target

A hidden structure inside the cell is rewriting how scientists understand leukemia. Beneath the microscope, what looked like disorder turned out to follow a simple physical rule—one that connects several major mutations ...

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For Localized Prostate Cancer, HIFU Is Not Worse Than Prostatectomy.

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Study reveals link between new-onset type 2 diabetes and some obesity-related cancers

FDA approves rivanetin as the first-line treatment for lung cancer.

A better option for mild to moderate depression?

Preferred and Actual Location of Death Often Don't Match for Young Cancer Patients

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