Today's Updates

TRPA1 Antagonist Shows Delayed but Meaningful Effect on IPF Cough Marlies Wijsenbeen, MD, PhD
Published Date: 20 Oct 2026

Marlies Wijsenbeek, MD, PhD, of Erasmus MC discusses BI 1839100, a TRPA1 antagonist, which missed its week-4 endpoint in a phase 2/2b trial.

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Mepolizumab Reduces Systemic Corticosteroid Exposure in Eosinophilic COPD Chelsie Derman
Published Date: 20 Oct 2026

In pooled phase 3 data, mepolizumab lowered mean yearly systemic corticosteroid exposure by 178.97 mg in patients with a BEC of ≥150 cells/µL.

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ASPEN: Sputum Color Associated With Bronchiectasis Disease Activity Victoria Johnson
Published Date: 20 Oct 2026

A post hoc analysis linked more purulent patient-reported sputum to higher neutrophil elastase activity and greater bronchiectasis disease activity.

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Sphingolipid Profiles May Distinguish IPF from Fibrotic HP
Published Date: 20 Oct 2026

Sphingolipid Profiles May Distinguish IPF from Fibrotic HP

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CHEST 2026: Day 1 Recap — 5 Headlines to Know
Published Date: 20 Oct 2026

CHEST 2026: Day 1 Recap — 5 Headlines to Know

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PAH Combination Therapy and Escalation: Clinical Forum Perspectives
Published Date: 20 Oct 2026

PAH Combination Therapy and Escalation: Clinical Forum Perspectives

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APP Experts Discuss Earlier Biologic Use in Asthma and COPD
Published Date: 20 Oct 2026

APP Experts Discuss Earlier Biologic Use in Asthma and COPD

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NeurologyLive® Friday 5 — October 16, 2026 Isabella Ciccone, MPH
Published Date: 20 Oct 2026

Take 5 minutes to catch up on NeurologyLive®'s highlights from the week ending October 16, 2026.

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RGX-202 Meets Primary End Point in Phase 3 Duchenne Trial Louie Pasculli
Published Date: 20 Oct 2026

Pivotal AFFINITY DUCHENNE results showed microdystrophin expression above the prespecified threshold in 93% of evaluable participants, with preliminary functional findings favoring treatment over external controls.

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Nipocalimab in Myasthenia Gravis: Real-World Use, Long-Term Safety, and the Road Ahead Marco Meglio, Leonard Dragone, MD, PhD
Published Date: 20 Oct 2026

Leonard Dragone, MD, PhD, Disease Area Leader at Johnson & Johnson, discusses how nipocalimab is being incorporated into generalized MG care, what long-term data show, and where J&J sees the therapy’s role evolving.

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Oral Icotrokinra Sustains UC Response Through 76 Weeks in ANTHEM-UC LTE Maria Abreu, MD
Published Date: 20 Oct 2026

Maria Abreu, MD, discusses 76-week ANTHEM-UC extension data showing once-daily oral icotrokinra maintained efficacy with no new safety signals in UC.

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Subcutaneous Infliximab Outperforms IV in Ileal Crohn’s Disease Analysis
Published Date: 20 Oct 2026

Subcutaneous Infliximab Outperforms IV in Ileal Crohn’s Disease Analysis

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VERDICT Links Vedolizumab Disease Clearance to Fewer UC Complications
Published Date: 20 Oct 2026

VERDICT Links Vedolizumab Disease Clearance to Fewer UC Complications

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Q&A: Nemolizumab Sustains Itch, Skin Gains in Early Responders at 3 Years
Published Date: 20 Oct 2026

Q&A: Nemolizumab Sustains Itch, Skin Gains in Early Responders at 3 Years

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Bitopertin Meets All Endpoints in Phase 3 APOLLO Trial for EPP
Published Date: 20 Oct 2026

Bitopertin Meets All Endpoints in Phase 3 APOLLO Trial for EPP

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Latest News

Rare Tumor in a Rare Location in Patient With Constipation

Could occupational exposure to sawdust explain this case?

ASTRO: American Society for Radiation Oncology

A Surgical First for Removal of an Appendiceal Neoplasm

Technique deemed safe and feasible for selected patients and better than other minimally invasive approaches

What's Behind the Mysterious Chest Pain in Bladder Cancer Patient?

Cardiomyopathy risks interrupting cancer treatment, worsening prognosis

Cancer Deaths Fall, Cases Rise; Diabetes and Cancer Risk; Vitamin C for Cancer

— News, features, and commentary about cancer-related issues

Benign or Malignant? No Way to Tell Radiologically

Case shows importance of accurate preop diagnosis

FDA Advisors Recommend Galleri Multicancer Blood Test

Some panelists had reservations about the test's true benefit, however

FDA Approves New Option for Previously Treated Bile Duct Cancer

— Trial of lirafugratinib showed responses in almost half of patients, with good durability

Optimizing Care Transitions and Referral Decision-Making Across the HNSCC Continuum

Optimizing Care Transitions and Referral Decision-Making Across the HNSCC Continuum

Here's Why Hematuria in a Young Patient Should Always Be Investigated

Terminology also makes a difference

Liver Failure or Liver Mets?

Diagnosis complicated by absence of radiologic evidence of hepatic lesions

Diagnosis of Mass Confined to the Kidney: Is It RCC or TCC?

Ureteroscopy and histopathology should be considered as routine preoperative assessments

BRAF Inhibition in Pediatric Ameloblastoma of the Jaw

Targeted therapy in 3 boys allowed for conservative surgery to restore jaw to predisease state

Transforming Perioperative MIBC Care in Community Practice: Navigating Emerging Data, Guideline Changes, and Adverse Event Management Protocols

Transforming Perioperative MIBC Care in Community Practice: Navigating Emerging Data, Guideline Changes, and Adverse Event Management Protocols

Doctors Remain Trusted Sources for Cancer Info in Post-Pandemic Era

Not surprisingly, trust in government health agencies for cancer info has dipped

Blood Cancer's First New Drug in 29 Years; AI for Mammography? Phase III Myeloma Win

News, features, and commentary about cancer-related issues

Latest News

Rare Tumor in a Rare Location in Patient With Constipation

Could occupational exposure to sawdust explain this case?

ASTRO: American Society for Radiation Oncology

A Surgical First for Removal of an Appendiceal Neoplasm

Technique deemed safe and feasible for selected patients and better than other minimally invasive approaches

What's Behind the Mysterious Chest Pain in Bladder Cancer Patient?

Cardiomyopathy risks interrupting cancer treatment, worsening prognosis

Cancer Deaths Fall, Cases Rise; Diabetes and Cancer Risk; Vitamin C for Cancer

— News, features, and commentary about cancer-related issues

Benign or Malignant? No Way to Tell Radiologically

Case shows importance of accurate preop diagnosis

FDA Advisors Recommend Galleri Multicancer Blood Test

Some panelists had reservations about the test's true benefit, however

FDA Approves New Option for Previously Treated Bile Duct Cancer

— Trial of lirafugratinib showed responses in almost half of patients, with good durability

Optimizing Care Transitions and Referral Decision-Making Across the HNSCC Continuum

Optimizing Care Transitions and Referral Decision-Making Across the HNSCC Continuum

Here's Why Hematuria in a Young Patient Should Always Be Investigated

Terminology also makes a difference

Liver Failure or Liver Mets?

Diagnosis complicated by absence of radiologic evidence of hepatic lesions

Diagnosis of Mass Confined to the Kidney: Is It RCC or TCC?

Ureteroscopy and histopathology should be considered as routine preoperative assessments

BRAF Inhibition in Pediatric Ameloblastoma of the Jaw

Targeted therapy in 3 boys allowed for conservative surgery to restore jaw to predisease state

Transforming Perioperative MIBC Care in Community Practice: Navigating Emerging Data, Guideline Changes, and Adverse Event Management Protocols

Transforming Perioperative MIBC Care in Community Practice: Navigating Emerging Data, Guideline Changes, and Adverse Event Management Protocols

Doctors Remain Trusted Sources for Cancer Info in Post-Pandemic Era

Not surprisingly, trust in government health agencies for cancer info has dipped

Blood Cancer's First New Drug in 29 Years; AI for Mammography? Phase III Myeloma Win

News, features, and commentary about cancer-related issues

News All Time

Blood Cancer's First New Drug in 29 Years; AI for Mammography? Phase III Myeloma Win

News, features, and commentary about cancer-related issues

More Evidence Ties Microplastics to Lung Cancer

Observational study shows greater microplastic burden in patients with lung malignancy

Nationwide Epinephrine Recall; FBI's Fauci Probe; Bruce Campbell's Cancer

Health news and commentary gathered by MedPage Today staff

9/11's Latest Wave of Cancers, 25 Years On

The health ramifications of the attack persist

Study Warns on Venetoclax in Double-Hit Lymphoma

Excess deaths seen in trial combining the BCL2 inhibitor with intensive initial regimen

Cancer Diagnosis, Then a Stroke; 9/11 Cancer Deaths; 'Grand Slam' Drug and Price

News, features, and commentary about cancer-related issues

Local Consolidative Therapy After Dual Immunotherapy Fizzles in Metastatic NSCLC

Overall survival favored nivolumab-ipilimumab alone in LONESTAR trial

Significant Survival Boost With Novel ADCs in Relapsed Small-Cell Lung Cancer

Death risk cut by 54% with B7-H3-targeting tambotatug pelitecan and risvutatug rezetecan

No Survival Bump in Metastatic NSCLC With Addition of ADC to Immunotherapy

Non-significant 4-month PFS increase with sacituzumab govitecan-pembrolizumab, no OS benefit

Cancer Drug Shortages Continue With No Immediate Path Toward Relief

All responding NCCN members reported shortages, priorities identified but solutions still needed

Brain MRI Surveillance Alone Helps Preserve Cognition in Small Cell Lung Cancer

Omitting prophylactic cranial irradiation led to improved cognitive failure-free survival

Nurse Accused of Exorcism; Death After 8 Hours of Plastic Surgery; Top Cancer Months

Health news and commentary gathered by MedPage Today staff

Novel Drug Cuts Risk for Death by 44% in Squamous Lung Cancer Trial

If approved, immunotherapy gotistobart could offer a chemo-free option in second-line setting

Unprecedented PFS in HER2-Mutant Lung Cancer, but With a Touch of Controversy

Practice-changing median of 14.3 months with T-DXd, but caution over early unfavorable OS trend

Drug Combo's Response Rates Top 90% in Small Cell Lung Cancer Trial

Bispecific antibody and ADC together impress in early study

ROS1-Targeting Lung Cancer Drug Yields 90% Response Rate

Early efficacy among the highest seen in lung cancer, expert says

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Nodal Response After Chemo Helps Tailor Breast Radiotherapy

How the skin cancer virus outperforms the replication of host cells.

The use of biomarkers in the treatment of breast lumps is at a crossroads.

Regular physical activity before cancer diagnosis may lower progression and death risks

Germline Variants Predict Lobular Breast Cancer Recurrence

A consensus statement from researchers on the proper use of Lu-177 PSMA-617 radionuclide therapy and patient selection is published.

The September 2018 issue of Medical Bulletin.

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