GnRH agonists for Endometriosis and Fibroids: Understanding the Science, Interpreting the Evidence, and Applying the Guidelines

Speciality: Obstetrics & Gynaecology


Speaker:

Mr. Dilip Kumar Sahu | Fertility Specialist

Description:

Today, let’s explore the role of GnRH agonists in managing endometriosis and fibroids. GnRH agonists work by suppressing ovarian hormone production, leading to reduced oestrogen levels. This hormonal environment helps shrink fibroids and alleviate endometriosis symptoms. Clinical evidence shows that these medications can provide significant symptom relief, but they can also cause side effects such as hot flushes and bone loss. Current guidelines recommend using GnRH agonists for short-term management, often with add-back therapy to minimise side effects. As always, individualised care is key, so decisions should be based on patient-specific factors and shared decision-making. Understanding the science and evidence ensures optimal outcomes for those affected.

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