The week in cardiology as of April 21st, 2023.

Published Date: 22 Apr 2023

John Mandrola's topics this week include early versus delayed AF ablation, a report on a catastrophic AF ablation complication, and a potential reversal for a significant therapeutic trend in electrophysiology.

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Latest News

Navigating the Mental and Emotional Effects of Breast Cancer

Dr Fumiko Chino discusses how a breast cancer diagnosis can trigger a wide range of emotional and mental health concerns, which can significantly impact daily life and relationships.

Prucalopride an Effective Adjunct for Colonoscopy Bowel Prep

A single dose of prucalopride given before a polyethylene glycol bowel prep regimen improves the quality of bowel cleansing in patients scheduled for elective colonoscopy.

Antidepressants in Pregnancy: New Data on Autism, ADHD Risk

A large meta-analysis shows no link between prenatal antidepressant exposure and autism or attention-deficit/hyperactivity disorder after adjusting for maternal mental health and other factors.

PD Risk Significantly Higher With Schizophrenia

The risk for Parkinson’s disease is significantly higher among patients with schizophrenia, with risk varying by type of antipsychotic therapy used, new research shows.

Preventing and Treating Postpartum Sexual Problems

Treat hemorrhoids, constipation, and vaginal dryness; start pelvic floor rehab early; and screen for incontinence and postnatal depression to support sexual recovery after childbirth.

Premature Ejaculation: Are Nondrug Options Emerging?

Combination treatment using pelvic floor therapy and medication may improve symptom control while supporting long-term adherence.

Todays Updates

NP-Led Outreach Ups Cancer Screening in Rural Women Veterans

A nurse practitioner-led outreach program improves the rates of breast and cervical cancer screening among women veterans in rural areas, a retrospective study shows.

Less Mental Decline With Darolutamide vs Enzalutamide in PC

Over half of patients in a randomized trial switch from enzalutamide to darolutamide because of cognitive issues; no one switches in the opposite direction.

Todays Updates

NP-Led Outreach Ups Cancer Screening in Rural Women Veterans

A nurse practitioner-led outreach program improves the rates of breast and cervical cancer screening among women veterans in rural areas, a retrospective study shows.

Less Mental Decline With Darolutamide vs Enzalutamide in PC

Over half of patients in a randomized trial switch from enzalutamide to darolutamide because of cognitive issues; no one switches in the opposite direction.

Latest News

Dr Fumiko Chino discusses how a breast cancer diagnosis can trigger a wide range of emotional and mental health concerns, which can significantly impact daily life and relationships.

A single dose of prucalopride given before a polyethylene glycol bowel prep regimen improves the quality of bowel cleansing in patients scheduled for elective colonoscopy.

A large meta-analysis shows no link between prenatal antidepressant exposure and autism or attention-deficit/hyperactivity disorder after adjusting for maternal mental health and other factors.

The risk for Parkinson’s disease is significantly higher among patients with schizophrenia, with risk varying by type of antipsychotic therapy used, new research shows.

Treat hemorrhoids, constipation, and vaginal dryness; start pelvic floor rehab early; and screen for incontinence and postnatal depression to support sexual recovery after childbirth.

Combination treatment using pelvic floor therapy and medication may improve symptom control while supporting long-term adherence.

News All Time

Colonoscopy Beyond 75: Are Risks Outweighing Benefits?

Researchers reportsd low colorectal cancer mortality after age 75, even among older adults with previous adenomas detected on colonoscopy.

New Benchmark for Reduced-Intensity Sickle Cell BMT Set

The Hopkins protocol may have solved one of the biggest problems in reduced-intensity sickle cell transplant — graft failure in children — with the added bonus of preserving fertility.

New Data: Perinatal MDD Peaks 2 Weeks After Birth

The rate of major depressive disorder is roughly 6% during pregnancy and 7% during the postpartum period, peaking at about 2 weeks after birth, new research shows.

Mixed Topline Results for Anti-Tau Agent in Phase 2 Trial

Although a new phase 2 study missed its primary endpoint, the anti-tau therapy diranersen reduces tau pathology and shows signs of slowing clinical decline in early AD.

Hormonal Therapies Underused for GSM in Menopause

Structural inequities and lack of information may keep patients from getting the therapies.

Radiotherapy Alters Brain Vessels in Paediatric Survivors

A prospective study reports that paediatric survivors of brain tumour develop cerebrovascular abnormalities 15 years post-radiotherapy with no change in their quality of life.

Can Common Psychostimulants Ease Cancer-Related Fatigue?

An updated meta-analysis suggests methylphenidate-based psychostimulants may modestly reduce cancer-related fatigue.

Trial Questions Extended Antibiotics After Bladder Removal

Omitting extended antibiotics after cystectomy did not increase the risk for urinary tract infection, according to interim results from a small randomized trial.

ASCO 2026: Previewing Updates on ADCs and SERDs in mBC

Dr Elizabeth Sakach expects ASCO 2026 data on ADCs and SERDs in metastatic breast cancer will focus on frontline use, sequencing, and socioeconomics.

Conference MDAngle: ASCO 2026 Early Breast Cancer

Insights from ASCO 2026, including anticipated presentations, key takeaways, and how emerging research in early breast cancer is poised to reshape treatment strategies

Transition From Pediatric to Adult HIV Care: Smooth for All?

Most youth living with HIV transition from pediatric to adult care, but fewer than half maintain timely and ongoing care, a South Carolina study finds.

PRECISE Score Predicts Prostate Cancer Progression

A multicentre validation of the PRECISE scoring system for prostate MRI shows that it effectively predicts disease progression and can reduce unnecessary biopsies for patients on active surveillance.

Insomnia Tied to Greater Symptom Burden in IBS

Insomnia affects a substantial subset of patients with irritable bowel syndrome and is linked to a higher burden of somatic and psychological symptoms and impaired quality of life.

Drug Combo May Be a Better Choice for Some Men With BPH

Treatment with tamsulosin and mirabegron appear to reduce urinary frequency and prostate symptoms more than monotherapy, a new study finds.

Few Pediatric Cancer Drugs Reach Phase 3 or Approval

Fewer than one out of five anticancer drugs that entered pediatric clinical testing advanced to phase 3 trials, and fewer still earned pediatric regulatory approval, according to recent analysis.

New Tool Predicts Self-Harm Risk in Substance Use Disorders

A large population-based study identifies clinical predictors and develops a validated risk model to help clinicians identify individuals with substance use disorders at high risk for self-harm.

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