Do Preprints Exaggerate Their Results?

Published Date: 22 Apr 2023

A recent study found that preprints provide spin in addition to new science. F. remarks made by Perry Wilson.

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In women with uncomplicated pregnancies, epidural analgesia during labor is linked to prolonged labor stages and increased clinical interventions compared with non-pharmacological pain relief methods.

The Hidden Health Risks of Borderline Personality Disorder

Dr Richard Zhang explains why clinicians should look beyond the psychiatric diagnosis of borderline personality disorder to recognize commonly coexisting medical conditions.

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Biopsy-Site Identification Technique

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Novel Nonopioid May Offer Acute Pain Relief

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Tissue-Free ctDNA Strongly Prognostic of Recurrence in TNBC

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Freeman’s Lobotomy to Deep Brain Stimulation: What Changed?

The history of lobotomy shows the risks for limited evidence and oversight, while modern approaches emphasize targeted treatment, informed consent, and rigorous evaluation.

Wide Variation Seen in Lung Screening False-Positive Rates

US radiologists vary substantially in their reading of low-dose CT lung cancer screens, highlighting a need for measures to help standardize interpretation.

AVD Chemo Regimen Shows Promise in Older Patients With HL

Researchers compare first-line chemotherapy regimens in older patients with classical Hodgkin lymphoma to assess whether AVD is associated with better outcomes in routine care.

Do High-Risk Features of Prostate Cancer Boost HT Benefit?

Researchers analyze individual patient data from five randomized phase 3 trials comparing PORT alone vs PORT plus hormone therapy in patients with recurrent prostate cancer.

How Low Does PSA Need to Go in Metastatic Prostate Cancer?

A new real-world analysis helps clarify the most informative prognostic PSA benchmark in men with metastatic castration-sensitive prostate cancer.

Tissue-Free ctDNA Strongly Prognostic of Recurrence in TNBC

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In women with uncomplicated pregnancies, epidural analgesia during labor is linked to prolonged labor stages and increased clinical interventions compared with non-pharmacological pain relief methods.

Dr Richard Zhang explains why clinicians should look beyond the psychiatric diagnosis of borderline personality disorder to recognize commonly coexisting medical conditions.

A misdiagnosed refractory fibromyalgia case shows Dr Michael Kaplan how broad widespread pain labels can obscure other underlying causes.

Confirming biopsy sites before Mohs micrographic surgery can be difficult when wounds have healed clinically and documentation is limited, risking wrong-site surgery.

Concerns about respiratory depression, dependence, and adverse effects shape opioid prescribing, while careful assessment and monitoring support safer, appropriate morphine use.

In a phase 2b trial, the selective Nav1.8 inhibitor LTG-001 is associated with reduced acute postsurgical pain, suggesting a potential new nonopioid approach.

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Medscape Physician Burnout & Depression Report 2026

The data are in and confirm what many doctors already know but few talk about: The emotional weight of medicine is still heavy.

Corticosteroid Shot Could Tame Pain After Fibroid Treatment

Intra-arterial administration of dexamethasone at time of embolization can be an effective adjunct to post-procedure analgesia.

UK PM Burnham Says Social Care Reform Should Come Before Assisted Dying Debate

Britain's new Prime Minister Andy Burnham said the debate over legalising assisted dying should ⁠wait until the country's palliative care and adult social care systems have...

Does Agent Choice Matter in Opioid-Free Bariatric Surgery?

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Deep Blockade May Cut Heart Rate Drops in Kids’ Eye Surgery

Children undergoing strabismus surgery who receive moderate-to-deep neuromuscular blockade have a lower incidence of oculocardiac reflex than those receiving minimal-to-shallow blockade.

Two Sedatives Tie on Pain, but Not Preference for JIA

In children with juvenile idiopathic arthritis, dexmedetomidine and nitrous oxide provide similar pain relief, but nitrous oxide delivers better overall patient experience.

A Tale of Two Deaths and Difficult Conversations

Two deaths, but one family struggled to accept brain death. Neurology resident Noor Shaik writes that we have defined brain and circulatory death, but are still learning how to talk about it.

GA During Thrombectomy May Boost Stroke Outcomes

General anesthesia during thrombectomy for acute ischemic stroke is tied to improved functional independence compared to nongeneral anesthesia methods, a meta-analysis shows.

Does Exercise Improve Sexual Function in Endometriosis?

Women with endometriosis-related pelvic pain who participated in supervised exercise and pelvic floor muscle training reported modest improvements in sexual function.

Does Remimazolam Match Propofol for Post-Op Delirium?

Remimazolam does not match propofol for postoperative delirium in older patients undergoing lung resection, with higher rates of emergence delirium with remimazolam.

HSV Reactivation Linked to Higher ICU Mortality in COVID

HSV type 1 reactivation was prevalent among critically ill patients with COVID-19 and was independently associated with increased need for organ support and reduced ICU survival.

General Anesthesia Ups Heart Failure Risk Post-Valve Surgery

Anesthesia choice during transcatheter aortic valve replacement is not associated with differences in mortality or most major complications within a year, except for heart failure.

WHO Introduces Ebola Test, Launches Treatment Trial

Researchers begin testing potential Ebola treatments as WHO expands access to a validated Bundibugyo virus assay during the largest recorded outbreak.

Regional Anesthesia May Aid Recovery Post-Orthopedic Surgery

Adding regional anesthesia to general anesthesia for major orthopedic surgery is associated with modestly better daily function at discharge than using general anesthesia alone.

Europe Sets New Rules for Pancreatitis Pain

A first-of-its-kind European consensus puts pain management at the center of acute pancreatitis care, including opioids, epidurals, and special populations.

5 Ways to Improve Care for Cancer Survivors

As more patients live longer after cancer, primary care clinicians are taking on a bigger role in spotting late effects and coordinating survivorship care.

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