The future of obesity management—quintuple and other super polyagonists for weight loss and maintenance?

Published Date: 24 Sep 2025

Much excitement has built in recent years on the new class of incretin drugs that include glucagon-like-peptide-1 inhibitors (single agonists such as semaglutide) and also dual glucose-dependent insulinotropic polypeptide ...

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University of Wisconsin-Milwaukee and University at Buffalo investigators report that diabetes fatalism is associated with lower mental health-related quality of life over 12 months in African American adults with poorly ...

New research found that restricting calories dramatically rewires proteins in rat skeletal muscle, causing molecular changes that boost insulin sensitivity—crucial for blood sugar control in older adults, say scientists ...

Prediabetes has long been thought to lead to type 2 diabetes, but according to new Deakin research, for some that isn't always the case.

Scientists have made a major breakthrough in understanding why type 1 diabetes is more aggressive in young children, offering the clearest explanation to date of why the condition is particularly difficult to manage when ...

An elevated blood glucose level one hour after the oral glucose tolerance test (OGTT) signals a critical metabolic state—even before prediabetes. Affected individuals respond particularly well to lifestyle interventions. ...

The Primary Oral Insulin Trial (POInT) investigates whether type 1 diabetes in at-risk children can be prevented through oral insulin treatment. First results mark an important step toward the prevention of type 1 diabetes, ...

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Finerenone reduces kidney damage in type 1 diabetes by lowering protein in urine

The drug finerenone has a positive effect on patients with type 1 diabetes and chronic kidney disease. The drug reduces the amount of proteins excreted in the urine of these patients. This reduction indicates that the degree ...

Therapies against cellular aging may help treat metabolic diseases

A growing body of evidence implicates cellular senescence—when cells age and permanently stop dividing—as an important contributor to metabolic dysfunction that can lead to obesity, type 2 diabetes, and metabolic syndrome.

Real-time glucose monitoring with professional support can improve type 1 diabetes control

People with type 1 diabetes achieved significantly better long-term blood glucose when their levels were monitored by health care professionals in real time, via a sensor under the skin, and they received regular advice in ...

Evolutionary comparison points to pigs as superior models for human pancreas and diabetes research

Pancreas development in pigs resembles humans much more closely than does the established mouse model. An international team headed by Helmholtz Munich and the German Center for Diabetes Research (DZD) has now produced a ...

Closed-loop insulin system improves glucose control during pregnancy, clinical trial finds

A collaborative effort across 14 clinical centers in Canada and Australia reports that pregnant women with type 1 diabetes using a closed-loop insulin system spent more time in the pregnancy-specific glucose range than those ...

Healthy lifestyle combined with newer diabetes medications lowers cardiovascular risk, preliminary study suggests

People with type 2 diabetes who combined healthy lifestyle habits with GLP-1 receptor agonist (GLP-1 RA) medications had a greater reduction in risk of major adverse cardiovascular events, including heart attack, stroke or ...

Cartoon-based diabetes education can enhance children's knowledge and physical activity

Researchers at University of Tsukuba reported that using manga as an educational tool in diabetes instruction for children can be equally effective as traditional lectures in enhancing diabetes-related knowledge and engagement ...

New model shows how treating diabetes early makes a difference

Could slightly elevated blood sugar levels lead to serious health problems in the future? A single patient's question sparked nearly a decade of research leading to the development of a landmark model that could shape how ...

Researcher provides new hope in managing diabetic ketoacidosis

A researcher at the University of Houston finds management of diabetic ketoacidosis may center around reducing ketone levels in diabetic patients and increasing exercise capacity for better health outcomes. That could be ...

Chemists design candidate drug against diabetes

Researchers from the University at Albany and NYU Grossman School of Medicine have found a way to block a key cellular pathway known to drive chronic inflammation and impaired wound healing in people with diabetes.

Exercise-induced vesicles help protect pancreatic cells and guard against diabetes

Exercise is known for the positive effects on metabolic diseases, partly because of the release of circulating extracellular vesicles (EVs) that mediate intercellular communication and organ crosstalk.

AI-powered diabetes prevention program shows similar benefits to those led by people

Researchers from Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health report that an AI-powered lifestyle intervention app for prediabetes reduced the risk of diabetes similarly to traditional, human-led ...

Bariatric surgery in a pill bottle

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Early trigger of diabetic eye disease identified

A team led by UCL scientists has identified a key protein that triggers diabetic retinopathy—a condition caused by high blood sugar damaging the retina's blood vessels and a leading cause of sight loss among working-age ...

African-Caribbean ethnicity key risk factor for sight-threatening diabetic eye disease

People of African-Caribbean ethnicity with Type 2 diabetes are a third more likely to develop a condition called sight-threatening diabetic retinopathy (STDR) than other ethnic groups, according to researchers from King's.

Remission achievable for 1 in 3 Indian diabetics through intensive app-based lifestyle program, study suggests

Nearly one-third of people with type 2 diabetes (T2D) in an Indian cohort have achieved remission through an intensive lifestyle intervention program, according to a study published in PLOS One by Pramod Tripathi of the Freedom ...

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