The future of obesity management—quintuple and other super polyagonists for weight loss and maintenance?

Published Date: 24 Sep 2025

Much excitement has built in recent years on the new class of incretin drugs that include glucagon-like-peptide-1 inhibitors (single agonists such as semaglutide) and also dual glucose-dependent insulinotropic polypeptide ...

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Latest News

University of Wisconsin-Milwaukee and University at Buffalo investigators report that diabetes fatalism is associated with lower mental health-related quality of life over 12 months in African American adults with poorly ...

New research found that restricting calories dramatically rewires proteins in rat skeletal muscle, causing molecular changes that boost insulin sensitivity—crucial for blood sugar control in older adults, say scientists ...

Prediabetes has long been thought to lead to type 2 diabetes, but according to new Deakin research, for some that isn't always the case.

Scientists have made a major breakthrough in understanding why type 1 diabetes is more aggressive in young children, offering the clearest explanation to date of why the condition is particularly difficult to manage when ...

An elevated blood glucose level one hour after the oral glucose tolerance test (OGTT) signals a critical metabolic state—even before prediabetes. Affected individuals respond particularly well to lifestyle interventions. ...

The Primary Oral Insulin Trial (POInT) investigates whether type 1 diabetes in at-risk children can be prevented through oral insulin treatment. First results mark an important step toward the prevention of type 1 diabetes, ...

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Finerenone reduces kidney damage in type 1 diabetes by lowering protein in urine

The drug finerenone has a positive effect on patients with type 1 diabetes and chronic kidney disease. The drug reduces the amount of proteins excreted in the urine of these patients. This reduction indicates that the degree ...

Therapies against cellular aging may help treat metabolic diseases

A growing body of evidence implicates cellular senescence—when cells age and permanently stop dividing—as an important contributor to metabolic dysfunction that can lead to obesity, type 2 diabetes, and metabolic syndrome.

Real-time glucose monitoring with professional support can improve type 1 diabetes control

People with type 1 diabetes achieved significantly better long-term blood glucose when their levels were monitored by health care professionals in real time, via a sensor under the skin, and they received regular advice in ...

Evolutionary comparison points to pigs as superior models for human pancreas and diabetes research

Pancreas development in pigs resembles humans much more closely than does the established mouse model. An international team headed by Helmholtz Munich and the German Center for Diabetes Research (DZD) has now produced a ...

Closed-loop insulin system improves glucose control during pregnancy, clinical trial finds

A collaborative effort across 14 clinical centers in Canada and Australia reports that pregnant women with type 1 diabetes using a closed-loop insulin system spent more time in the pregnancy-specific glucose range than those ...

Healthy lifestyle combined with newer diabetes medications lowers cardiovascular risk, preliminary study suggests

People with type 2 diabetes who combined healthy lifestyle habits with GLP-1 receptor agonist (GLP-1 RA) medications had a greater reduction in risk of major adverse cardiovascular events, including heart attack, stroke or ...

Cartoon-based diabetes education can enhance children's knowledge and physical activity

Researchers at University of Tsukuba reported that using manga as an educational tool in diabetes instruction for children can be equally effective as traditional lectures in enhancing diabetes-related knowledge and engagement ...

New model shows how treating diabetes early makes a difference

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Chemists design candidate drug against diabetes

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AI-powered diabetes prevention program shows similar benefits to those led by people

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Bariatric surgery in a pill bottle

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