Triple Therapy in Metastatic CRC With BRAF Mutations: The New Standard of Care?

Published Date: 28 Jan 2025

Expert calls encorafenib-cetuximab-mFOLFOX6 in first-line "practice changing"

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Quebec’s health ministry is opposing experts’ recommendation to lower the colorectal cancer screening age to 45 years.

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Researchers randomized about 1200 patients undergoing elective surgery for digestive cancer to receive either methylprednisolone or placebo at anesthesia induction.

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HCT Survival Outcomes Improving in Relapsed Hodgkin Lymphoma

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Taylor Farms, the produce supplier at the center of the massive U.S. cyclosporiasis outbreak, changed the way that America eats after launching branded, prepackaged and...

The Centers for Disease Control and Prevention on Tuesday reported 15,716 confirmed cases of ⁠cyclosporiasis in the United States, an increase of 1,821 cases from a week...

Quebec’s health ministry is opposing experts’ recommendation to lower the colorectal cancer screening age to 45 years.

In colon capsule endoscopy, chronic opioid use is linked to incomplete examinations and inadequate bowel preparation, whereas diabetes is tied to poorer bowel preparation.

Researchers randomized about 1200 patients undergoing elective surgery for digestive cancer to receive either methylprednisolone or placebo at anesthesia induction.

Gastrointestinal hypomotility is the most lethal adverse event linked to clozapine use. GLP-1s slow the gut too. Clinicians are combining the two, with little safety data to guide them.

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Acting US FDA Chief Urges Confidence in Lettuce as Agency Updates Produce Safety Guidance

Acting U.S. FDA Commissioner Kyle Diamantas said on Tuesday Americans should feel confident in eating fresh produce, as the agency has finalized guidance for proper...

Listeriosis Incidence Stable Despite Aging Population

The incidence of invasive listeriosis has remained stable in the US from 2008 to 2023, although certain groups face disproportionately higher rates.

‘Concerning’ Trends in Cancer Drug Approvals

FDA approvals for solid tumor drugs increasingly rely on response rates as the primary evidence supporting approval rather than overall survival.

What to Know About the Multistate Salmonella Outbreak in the US

(Removes abbreviation in paragraph 2 and makes 'salmonella' lowercase throughout)

US FDA to Hold Advisory Meeting to Review Grail's Multi-cancer Test

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US Cyclosporiasis Probe Linked to Lettuce Widens to 15 States

U.S. health authorities have widened their probe into a cyclosporiasis outbreak tied to iceberg lettuce from central Mexico after detecting cases in six additional states,...

Mexican Jalapenos Tied to Salmonella Outbreak in 27 US States

U.S. health officials are investigating a Salmonella outbreak linked to Mexican jalapeno peppers that has sickened 345 people in 27 states, prompting supplier ⁠Coast Citrus...

Genetic Marker Linked to Severe Outcomes Across IBD Subtypes

HLA-DRB1*01:03 may serve as a genetic marker for severe outcomes across IBD phenotypes and help identify patients at higher risks for surgery and treatment failure.

Does High-Dose Vitamin D3 Supplementation Improve CRC Survival?

A phase 3 trial was conducted to confirm the benefit of high-dose vitamin D3 supplementation in patients with previously untreated metastatic CRC that was seen in a phase 2 trial.

IV Vitamin C With Chemo Shows Signals in Cancer Care

A phase 2 study reported a longer median overall survival in patients receiving IV ascorbate with chemotherapy, although larger randomized trials are needed to confirm the finding.

Small Colorectal Lesions Carry Risk for Deep Invasion

Non-pedunculated colorectal lesions smaller than 2 cm may harbor deep submucosal invasion despite their diminutive size, study finds.

Etrasimod Effective As First-Line Advanced UC Therapy

Etrasimod can be an effective and safe first-line advanced therapy option in patients with ulcerative colitis who escalate after conventional treatment failure.

Does Doublet Chemotherapy Improve Survival in Rectal Cancer?

Patients with high-risk locally advanced rectal cancer were randomly assigned to receive doublet-LC TNT or conventional neoadjuvant chemoradiotherapy.

Radiation Boost Linked to Better Survival in Rectal Cancer

A phase 2 trial finds that adding a modest radiation boost improves 9-year survival without increasing toxicity, despite no improvement in pathologic complete response.

Creatinine Assay Bias Affects MELD Scoring

Bilirubin interference in commonly used creatinine assays artificially inflates MELD scores in liver transplant candidates, a study reports.

EHR Marker May Help Curb Risk for Liver Transplant Rejection

A remote intervention aimed at improving medication adherence may reduce organ rejection in liver transplant recipients at high risk.

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