FDA Approves First Non-Antipsychotic Drug for Alzheimer's Agitation

Published Date: 12 May 2026

Oral NMDA receptor antagonist gets an expanded indication

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Brief Brain Stimulation Effective for Depression in PD

Intermittent theta-burst stimulation matches the efficacy of standard transcranial magnetic stimulation for depression in Parkinson’s disease but with a shorter treatment time, new research shows.

In MS, Stem Cell Transplant Sometimes Looks Like Cure

Autologous hematopoietic stem cell transplant at experienced centers in the current era can include indefinite disease control with low relative risk, a new update suggests.

AD Biomarkers Tied to Worse Cognition in Midlife Adults

Alzheimer’s disease pathology, measured by amyloid and tau blood biomarkers, can appear in midlife and is associated with worse cognitive performance years before dementia onset.

Lumateperone Linked to Lower Risk for Schizophrenia Relapse

Lumateperone was associated with a 63% lower risk for relapse and was well-tolerated among patients with schizophrenia.

CMS Rule Misses Mark on CPAP Adherence

A Kaiser Permanente study shows some people who initially struggle with CPAP adherence still use the device at 1 year, suggesting CMS’ 90-day cutoff is too strict.

New Imaging Agent Could Speed Detection of AD-Related Tau

A novel PET imaging agent identified AD-related tau earlier and in more patients than the currently used tracer, possibly speeding AD detection, a new study shows.

Todays Updates

HIV Care Coordination Program May Reduce Deaths in NYC

New York City’s revised Care Coordination Program may help reduce risks for all-cause and HIV-related deaths among people with HIV infection, including those at the highest risk for poor outcomes.

Teplizumab Approved for Pediatric Stage 3 Type 1 Diabetes

The drug was previously approved for stage 2 T1D.

One in Four Teen Girls and Young Women at Risk for PMOS

Findings suggest young females should be assessed and, if at risk, monitored.

Palopegteriparatide Benefits Sustained Beyond 3 Years

Final results from the PaTHway trial show the long-acting parathyroid hormone therapy enabled patients with hypoparathyroidism to achieve independence from high-dose calcium and vitamin D supplements.

Testosterone Prescribing Often Ignores Guidelines

Only 12% of patients prescribed testosterone underwent appropriate diagnostic testing, and overprescribing was common in a single-center US study.

Encaleret Shows Rapid Response in ADH1

The oral modulator of the calcium-sensing receptor targets the causes of ADH1, significantly improving serum and urine calcium levels.

Off-Label Rxs: Thinking Out of the Box for Skin Diseases

Off-label alternatives for FDA-approved therapies can be as effective, cheaper, and in some cases safer despite never having been submitted for regulatory approval.

Todays Updates

HIV Care Coordination Program May Reduce Deaths in NYC

New York City’s revised Care Coordination Program may help reduce risks for all-cause and HIV-related deaths among people with HIV infection, including those at the highest risk for poor outcomes.

Teplizumab Approved for Pediatric Stage 3 Type 1 Diabetes

The drug was previously approved for stage 2 T1D.

One in Four Teen Girls and Young Women at Risk for PMOS

Findings suggest young females should be assessed and, if at risk, monitored.

Palopegteriparatide Benefits Sustained Beyond 3 Years

Final results from the PaTHway trial show the long-acting parathyroid hormone therapy enabled patients with hypoparathyroidism to achieve independence from high-dose calcium and vitamin D supplements.

Testosterone Prescribing Often Ignores Guidelines

Only 12% of patients prescribed testosterone underwent appropriate diagnostic testing, and overprescribing was common in a single-center US study.

Encaleret Shows Rapid Response in ADH1

The oral modulator of the calcium-sensing receptor targets the causes of ADH1, significantly improving serum and urine calcium levels.

Off-Label Rxs: Thinking Out of the Box for Skin Diseases

Off-label alternatives for FDA-approved therapies can be as effective, cheaper, and in some cases safer despite never having been submitted for regulatory approval.

Latest News

Intermittent theta-burst stimulation matches the efficacy of standard transcranial magnetic stimulation for depression in Parkinson’s disease but with a shorter treatment time, new research shows.

Autologous hematopoietic stem cell transplant at experienced centers in the current era can include indefinite disease control with low relative risk, a new update suggests.

Alzheimer’s disease pathology, measured by amyloid and tau blood biomarkers, can appear in midlife and is associated with worse cognitive performance years before dementia onset.

Lumateperone was associated with a 63% lower risk for relapse and was well-tolerated among patients with schizophrenia.

A Kaiser Permanente study shows some people who initially struggle with CPAP adherence still use the device at 1 year, suggesting CMS’ 90-day cutoff is too strict.

A novel PET imaging agent identified AD-related tau earlier and in more patients than the currently used tracer, possibly speeding AD detection, a new study shows.

News All Time

Primary Care Making More Mental Health Diagnoses for Kids

Pediatric mental health visits in primary care surged over a 9-year period.

Electroacupuncture Promising for Cognitive Improvement in AD

Electroacupuncture was associated with long-term efficacy in improving cognitive function compared to sham treatment in patients with Alzheimer’s disease, a new trial shows.

Undiagnosed Dementia Tied to Increased Mortality Risk

Undiagnosed dementia is highly prevalent in the US and Brazil and is linked to increased 4-year mortality in both countries, a large cohort study shows.

Coffee Linked to Better Cognition in Patients With PD

Coffee consumption is associated with improved executive function in patients with early Parkinson’s disease, while smoking has no impact, a new study suggests.

How One Psilocybin Trip May Reshape the Brain

New research suggests a single high dose of psilocybin alters neural activity and may trigger lasting structural brain changes tied to improved well-being.

Brain Cooling Boosts LVO Recovery After Thrombectomy

Targeted intra-arterial cooling delivered during clot retrieval significantly increases functional independence after large-vessel ischemic stroke, with no added risk.

Optimal Sleep May Lower Dementia Risk in Focal Epilepsy

Optimal sleep duration is tied to better cognition and a lower risk for dementia in adults with focal epilepsy than in healthy individuals, new research shows.

A Stepwise Approach Can Support Healthy Sleep in Children

Minimize the use of medications that counteract melatonin as well as stimulating activities that trigger cortisol, one researcher advised.

AHA Reframes Brain Health as a Lifelong Process

A new AHA scientific statement says sleep, mental health, pollution, and childhood adversity can shape cognitive aging and dementia risk, underscoring that brain health is built across a lifetime.

FDA Approves Ocrelizumab for Pediatric Relapsing MS

The FDA approval makes ocrelizumab a new treatment option for children aged 10 years and older with relapsing-remitting multiple sclerosis.

Roche Gets Second European Approval for Alzheimer's Test

Swiss drugmaker Roche has received the CE mark - a ⁠European regulatory clearance allowing sale in the region - for its second ⁠Elecsys blood test for Alzheimer's disease.

Multimodal Approach Can Manage Depression in Children

Psychotherapy is the intervention of first choice, and pharmacotherapy can be considered when psychotherapy alone is not effective, one psychiatrist says.

Decoding Spinal Muscular Atrophy (SMA): From Phenotypic Diversity to Early Diagnosis

Decoding Spinal Muscular Atrophy (SMA): From Phenotypic Diversity to Early Diagnosis

Rewriting the Code: Gene Therapy and the Future of Spinal Muscular Atrophy (SMA) Treatment

Rewriting the Code: Gene Therapy and the Future of Spinal Muscular Atrophy (SMA) Treatment

Collaborative Approaches to Detecting and Addressing Silent Disease Progression in Multiple Sclerosis

Collaborative Approaches to Detecting and Addressing Silent Disease Progression in Multiple Sclerosis

Boost Your Multifocal Motor Neuropathy (MMN) Expertise: Emerging Therapies in Focus

Boost Your Multifocal Motor Neuropathy (MMN) Expertise: Emerging Therapies in Focus

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