Short-term contraception for men? Mouse studies suggest this is possible.

Published Date: 17 Feb 2023

A man takes a small pill before hoping to flirt with his girlfriend.

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Non-opioid pain relief: Brain's 'cleanup crew' reveals a new target

Chronic pain is a daily reality for millions of Americans, interfering with their everyday activities and quality of life. An estimated 24.3% of adults in the United States experienced chronic pain in 2023, and current treatment ...

Clinical trial countries often left without new medicines they helped test

A new study led by Yale's Jennifer Miller, Ph.D., found that medicines are not physically accessible in many of the countries where they are tested for FDA approval. The findings were published in JAMA Internal Medicine.

New study identifies part of brain animals use to make inferences

Animals survive in changing and unpredictable environments by not merely responding to new circumstances, but also, like humans, by forming inferences about their surroundings—for instance, squirrels understand that certain ...

Researcher out to solve mystery of migraine

Often dismissed as a minor ailment, migraine is a debilitating neurological disease affecting hundreds of thousands of New Zealanders. At the University of Otago's School of Biomedical Sciences, world-leading research by ...

Why snake pee may be key to treating kidney stones and gout

Scientists think snakes and lizards could help them find new ways to prevent painful kidney stones and gout in people. And it all owes to an evolutionary trick.

Scientific researchers urge Congress to increase funding to the NIH as the shutdown ends

The record-breaking federal government shutdown marked yet another impediment to scientific research efforts at the Wistar Institute this year.

Todays Updates

Adrenal Incidentalomas: When to Worry and What to Test

Not all adrenal incidentalomas need the same workup. The Curbsiders break down when to worry, what to test, and why MACS may be behind your patient's hard-to-control metabolic disease.

Understanding the 'Wait Time Paradox' in Ovarian Cancer

Dr Maurie Markman examines new registry data on ovarian cancer diagnostic timing, showing how disease biology can complicate the link between early detection and survival.

Adapting Approaches in the Fibromyalgia Landscape

Dr Andrea Chadwick describes how the shift from tender points to symptom-based criteria has improved fibromyalgia diagnosis, understanding, and patient-centered care.

The Expanding Use of CGM for Diabetes

Dr Anne Peters discusses the expanding use of continuous glucose monitoring in people with diabetes.

Four Signs You Should Biopsy a Skin Lesion, Not Freeze It

Before you freeze a skin lesion, ask yourself whether you really know what it is. Here are four signs you should biopsy instead of freeze.

EyePoint's Drug for Age-related Eye Disease Fails Late-stage Trial, Shares Tank

EyePoint said its experimental drug missed the main goal in a late-stage trial as a few patients lost vision ⁠from causes unrelated to the targeted disease, sending its...

FDA Approves Brain-imaging Agent for Alzheimer's Assessment

The FDA has approved a radioactive agent for use ⁠in brain scans to help assess patients for Alzheimer's disease.

Todays Updates

Adrenal Incidentalomas: When to Worry and What to Test

Not all adrenal incidentalomas need the same workup. The Curbsiders break down when to worry, what to test, and why MACS may be behind your patient's hard-to-control metabolic disease.

Understanding the 'Wait Time Paradox' in Ovarian Cancer

Dr Maurie Markman examines new registry data on ovarian cancer diagnostic timing, showing how disease biology can complicate the link between early detection and survival.

Adapting Approaches in the Fibromyalgia Landscape

Dr Andrea Chadwick describes how the shift from tender points to symptom-based criteria has improved fibromyalgia diagnosis, understanding, and patient-centered care.

The Expanding Use of CGM for Diabetes

Dr Anne Peters discusses the expanding use of continuous glucose monitoring in people with diabetes.

Four Signs You Should Biopsy a Skin Lesion, Not Freeze It

Before you freeze a skin lesion, ask yourself whether you really know what it is. Here are four signs you should biopsy instead of freeze.

EyePoint's Drug for Age-related Eye Disease Fails Late-stage Trial, Shares Tank

EyePoint said its experimental drug missed the main goal in a late-stage trial as a few patients lost vision ⁠from causes unrelated to the targeted disease, sending its...

FDA Approves Brain-imaging Agent for Alzheimer's Assessment

The FDA has approved a radioactive agent for use ⁠in brain scans to help assess patients for Alzheimer's disease.

Latest News

Chronic pain is a daily reality for millions of Americans, interfering with their everyday activities and quality of life. An estimated 24.3% of adults in the United States experienced chronic pain in 2023, and current treatment ...

A new study led by Yale's Jennifer Miller, Ph.D., found that medicines are not physically accessible in many of the countries where they are tested for FDA approval. The findings were published in JAMA Internal Medicine.

Animals survive in changing and unpredictable environments by not merely responding to new circumstances, but also, like humans, by forming inferences about their surroundings—for instance, squirrels understand that certain ...

Often dismissed as a minor ailment, migraine is a debilitating neurological disease affecting hundreds of thousands of New Zealanders. At the University of Otago's School of Biomedical Sciences, world-leading research by ...

Scientists think snakes and lizards could help them find new ways to prevent painful kidney stones and gout in people. And it all owes to an evolutionary trick.

The record-breaking federal government shutdown marked yet another impediment to scientific research efforts at the Wistar Institute this year.

News All Time

Research gap discovered: 1 in 21 adults affected by mental disorders omitted from global health study

Mental disorders that cause physical symptoms are not included in a major health trends study, despite them impacting as many as 1 in 21 adults, researchers have found.

Scientists complete first drafts of developing mammalian brain cell atlases

A global consortium of scientists has created the first and most detailed "developmental maps" of the mammalian brain (from mouse to human) to date, taking the first critical steps in unraveling the mystery of early brain ...

Slowed by sound: Mouse model of Parkinson's disease shows noise affects movement

In the development of Parkinson's disease, it may not be a good idea to turn the amp to 11. High-volume noise exposure produced motor deficits in a mouse model of early-stage Parkinson's disease, and established a link between ...

'Molecular glues' and 'bumpers' offer new hope for precision medicines

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest ...

Astringent, sharper mind: Flavanols can trigger brain activity for memory and stress response

Astringency is a dry, puckering, rough, or sandpapery sensation in the mouth caused by plant-derived polyphenols. Polyphenols, including flavanols, are well known for risk reduction in cardiovascular diseases.

Opening the door to a vaccine for multiple childhood infections

A vaccine that tackles the bacteria that cause up to 200 million childhood infections every year could be possible, experts say.

Hundreds of animal studies on brain damage after stroke flagged for problematic images

A new study has identified over 240 scientific publications on animal models of hemorrhagic stroke that contain potentially problematic images, thereby raising concerns about the trustworthiness of the body of literature ...

Decentralized future: Expanding clinical trials by allowing people to participate from home

As the world becomes more digital, clinical research is evolving. One major change is the rise of decentralized clinical trials, or DCTs. Unlike traditional trials that require participants to visit hospitals or research ...

In drug trials, lack of oversight of research ethics boards could put Canadian patients at risk

New drug approvals by Health Canada are based on the results of clinical trials. But before clinical trials can go ahead, they need to be approved by ethics committees known as Research Ethics Boards (REBs).

Discovery of 'doorstop' for brain's electrical gates may open path to new therapies for neurodegenerative conditions

As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At Cold Spring Harbor Laboratory (CSHL), scientists have turned their attention to the tiny pores that let charged ions ...

WHO's priorities shaped by its reliance on grants from donor organizations, study suggests

The World Health Organization's (WHO's) priorities are being skewed by its increasing reliance on donations from organizations such as the Gates Foundation (previously known as the Bill and Melinda Gates Foundation), which ...

Opt-out organ donation policies may reduce organ supply

Every day, 17 Americans die while waiting for an organ transplant. Opt-out organ donation policies, which enroll everyone into post-mortem donation programs by default unless people choose to opt out, have been touted as ...

New Hampshire man resumes dialysis after record 271 days living with a pig kidney

A New Hampshire man is resuming dialysis after living with a gene-edited pig kidney for a record 271 days, doctors said Monday. His experience is helping researchers in their quest for animal-to-human transplants.

Liver transplantation utilizing grafts donated after euthanasia is feasible, study suggests

Organ donation following medical assistance in dying (MAiD), also known as euthanasia, is a relatively new practice both in North America and worldwide. A first comparison of liver transplantation using organs donated after ...

A 'bird's eye view' of how human brains operate

A new study provides the best evidence to date that the connection patterns between various parts of the human brain can tell scientists the specialized functions of each region.

Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor

Deciphering how the GR forms oligomers—through the binding of several subunits—opens a crucial avenue for developing more selective drugs. These new drugs could modulate this association and thus minimize serious adverse ...

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