AGA Updates POWER Guide for Obesity, Weight Management

Published Date: 20 Jun 2026

Updated guidance from the American Gastroenterological Association aims to help clinicians navigate the growing number of obesity and weight-management treatment options.

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In patients with obesity and knee osteoarthritis eligible for knee arthroplasty, an intensive dietary weight-loss program is clinically inferior to surgery for patient-reported pain and function.

Incretin mimetic therapy for obesity may reduce muscle mass and bone mineral density, but its effects on physical function and the risk for fractures in older adults remain uncertain.

An increase in dietary spermidine intake over 1 year is associated with improvements in hepatic function and cardiometabolic health in older adults with overweight or obesity and metabolic syndrome.

Ultrasound imaging reveals structural changes in the vagus nerve of patients with Parkinson's disease in a meta-analysis.

Using both SGLT2 inhibitors and GLP-1 receptor agonists is no more effective than using either drug alone in patients with type 2 diabetes, a new meta-analysis suggests.

A mindfulness-based eating intervention improved anxiety, depression, and eating behaviors in adults with obesity and generalized anxiety disorder.

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Glucose, A1c Mediate Obesity-Pancreatic Cancer Link

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Semaglutide Tied to Lower Risk for Adult-Onset Seizure

In adults with type 2 diabetes, semaglutide initiation was associated with roughly half the risk for adult-onset seizure compared with other glucose-lowering medications — a protective effect that appeared independent of blood sugar or weight control.

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Kidney Disease Hits Early, Hard in Kids With Spina Bifida

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India Approves Novo Nordisk's Obesity Drug Wegovy for Fatty Liver Disease

Danish drugmaker Novo Nordisk said on Friday that India's drug regulator has approved its ⁠obesity drug Wegovy for the treatment of metabolic dysfunction-associated...

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Glucocorticoid Use in Giant Cell Arteritis Remains High

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Does High Cortisol Shut Down GLP-1s?

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Managing Diabetes and HIV Together: What to Know

As people with HIV live longer, diabetes is becoming an increasingly important contributor to morbidity and mortality, requiring specialized management approaches.

GLP-1s May Reduce Overdose Risk, Even After Discontinuation

People with a history of alcohol, opioid, or substance overdose who are later started on GLP-1 medications have a significantly lower risk for a repeat overdose.

South Africa's IDexis Appeals Court Ruling Over Compounded Weight-loss Drugs

South African pharmacy group iDexis said on Tuesday it had applied to appeal a court judgment that curbed its production ⁠of compounded weight-loss medicines, disputing...

Study Flags Need to Monitor Frailty Risks With GLP-1 Drugs for Older Adults

Potential signs of frailty in older adults taking Eli Lilly’s GLP-1 obesity drug Zepbound may signal relatively high risks for adverse outcomes, according to a large study...

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Do Infant Food Portion Sizes Matter for Later Overweight?

Larger food portions during complementary feeding are associated with higher odds of overweight in both early and later childhood.

Semaglutide Linked to Rare Brain Illness

In rare cases, semaglutide for obesity is linked to Wernicke encephalopathy, driven by gastrointestinal intolerance, reduced nutritional intake, and rapid weight loss leading to thiamine deficiency.

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