Sodium Channel Blocker Relieves Acute Pain in Phase III Data

Published Date: 25 Oct 2024

Trials favor a first new class of pain drug in years

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Bloating is one of patients' most common gastrointestinal complaints. Dr Alicia Muratore kicks off this six-part series by asking why bloating is often treated as an afterthought.

S1 Episode 4: Urinary Tract Infections and Sexual Function

Drs Anne Lenore Ackerman and Rachel S. Rubin discuss urinary tract infections, sexual function, quality of life, and the importance of patient education.

Immunotherapy Promises New Era in Cancer Prevention

Prof David Kerr explores whether PD-1 inhibitors and targeted vaccines can regress polyps and prevent secondary cancers in Lynch syndrome.

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Dr Andrea Chadwick explains how empowering primary care to own long-term diagnosis and management of fibromyalgia could transform outcomes for these patients.

Your patient qualifies for retatrutide's expanded-access program. Now comes the hard part: three gatekeepers, no coordination, and no appeals process.

Propofol infusion may not offer better 30-day recovery or survival outcomes after major noncardiac surgery compared with inhaled anesthetics, a study finds.

Opioid use disorder is associated with a higher risk for complications before discharge after inpatient removal of the uterus.

Dr Andrea Chadwick describes gradually recognizing patterns of widespread pain on body maps, which led her to take a bird’s eye view and better identify fibromyalgia.

A recent study reveals differences in critical care needs across delivery modes, with intrapartum and intended cesarean births linked to increased odds of ICU admission.

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Novel Nonopioid May Offer Acute Pain Relief

In a phase 2b trial, the selective Nav1.8 inhibitor LTG-001 is associated with reduced acute postsurgical pain, suggesting a potential new nonopioid approach.

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Weight-Loss Procedure Feasible in Outpatient Setting

Endoscopic sleeve gastroplasty performed in an ambulatory setting appears safe and feasible in selected patients with obesity, with only a few patients requiring unplanned hospitalization.

Cardiac Arrests Very Rare During Endoscopy

Cardiac arrests during endoscopic procedures in the hospital are associated with lower mortality than those with other in-hospital cardiac arrests.

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Chronic Back Pain Treatment: Why Integrated Care Is Needed

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Lidocaine Matches Nerve Block for Knee Surgery Pain

Lidocaine infusion matches nerve block in terms of opioid use at 24 hours after knee replacement surgery, a study finds.

New Fibromyalgia Genetics Discovery: An Author’s Perspective

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Doctors often overlook or misunderstand important metrics and incentives in their compensation plan, which can drag down their income.

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Medscape Physician Burnout & Depression Report 2026

The data are in and confirm what many doctors already know but few talk about: The emotional weight of medicine is still heavy.

Corticosteroid Shot Could Tame Pain After Fibroid Treatment

Intra-arterial administration of dexamethasone at time of embolization can be an effective adjunct to post-procedure analgesia.

UK PM Burnham Says Social Care Reform Should Come Before Assisted Dying Debate

Britain's new Prime Minister Andy Burnham said the debate over legalising assisted dying should ⁠wait until the country's palliative care and adult social care systems have...

Does Agent Choice Matter in Opioid-Free Bariatric Surgery?

In patients undergoing sleeve gastrectomy, opioid-free anesthesia with propofol or sevoflurane provides similar pain relief and postoperative nausea, but propofol is linked to delayed emergence.

Two Sedatives Tie on Pain, but Not Preference for JIA

In children with juvenile idiopathic arthritis, dexmedetomidine and nitrous oxide provide similar pain relief, but nitrous oxide delivers better overall patient experience.

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