Trials of Disease-Modifying Therapies for Multiple Sclerosis Ignored the Effects of Fatigue.

Published Date: 12 Nov 2023

Only 5% of trials involving disease-modifying therapies for MS patients evaluated fatigue as an outcome, and only 28% of the 7 trials that included this measurement produced statistically significant results, according to a recent systematic review.

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Novel, Adaptive DBS Tied to Fewer Falls in Parkinson’s

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Enhancing Comprehensive Biomarker Testing and Biomarker-Directed Treatment Selection

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Belzutifan and pembrolizumab together reduced the risk of disease recurrence or death

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Capivasertib plus abiraterone combination lands indication for PTEN-deficient tumors

Talquetamab Regimens Boost Survival in Multiple Myeloma

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In High-Risk B-Cell ALL, Swapping Out Chemo for Blinatumomab Improves Outcomes

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Latest News

Ocular motor cranial neuropathy is associated with an increased risk for Parkinson’s disease, a new study shows.

Traumatic brain injury is bidirectionally associated with the incidence of stroke, dementia, epilepsy, and Parkinson’s disease, a retrospective study shows.

Targeted interventions, especially avatar therapy, are associated with less severe auditory hallucinations in patients with schizophrenia, a new meta-analysis shows.

In a small feasibility study, a novel adaptive DBS system synchronized with the walking cycle has been shown to reduce the risk for falls among patients with Parkinson’s disease.

Electroconvulsive therapy (ECT) is associated with longer time to hospital readmission or suicide compared to non-ECT treatment in patients with schizophrenia, a study shows.

Comorbid primary sleep disorders are tied to higher risk for sudden unexpected death, all-cause mortality, and accidents in patients with epilepsy, a new study finds.

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In MS, Stem Cell Transplant Sometimes Looks Like Cure

Autologous hematopoietic stem cell transplant at experienced centers in the current era can include indefinite disease control with low relative risk, a new update suggests.

AD Biomarkers Tied to Worse Cognition in Midlife Adults

Alzheimer’s disease pathology, measured by amyloid and tau blood biomarkers, can appear in midlife and is associated with worse cognitive performance years before dementia onset.

Lumateperone Linked to Lower Risk for Schizophrenia Relapse

Lumateperone was associated with a 63% lower risk for relapse and was well-tolerated among patients with schizophrenia.

CMS Rule Misses Mark on CPAP Adherence

A Kaiser Permanente study shows some people who initially struggle with CPAP adherence still use the device at 1 year, suggesting CMS’ 90-day cutoff is too strict.

New Imaging Agent Could Speed Detection of AD-Related Tau

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Federally Funded Research Backs Tighter Drinking Limits

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Melatonin Gummies Blur Line Between Medicine and Candy

Pediatricians call for a ban on melatonin gummy bears and similar products, warning that candy-like supplements may encourage unsupervised use in children.

A New Option for Headache?

Findings come from a single-center study suggest the non-opioid suzetrigine may help reduce pain in multiple headache types, but more research is needed.

NfL a Biomarker for Cognitive Function in Patients With MS?

New data offer strong evidence that neurofilament light chain (NfL) levels could be an accurate biomarker for monitoring cognitive function in MS.

Most ‘Sleep-Divorced’ Couples Support Sleeping Separately

A study in Brazil reveals the prevalence and attitudes among couples not driven by relationship stress toward ‘sleep divorce’ arrangements.

Experimental Drug Cuts Migraine Days in Mid-stage Trial

Denmark's Lundbeck said on Thursday its experimental drug bocunebart cut monthly migraine days in ⁠a mid-stage study, supporting further development of a new type of...

Spinal Cord Treatment Triggers Hope and Lawsuits in Brazil

An experimental treatment for spinal cord injuries is drawing patients from as far as Mexico, mobilizing the government to expedite approval before its safety has been proven in a clinical trial.

Global Lewy Body Dementia Incidence: New Data

The first known analysis of pooled worldwide population-based data on dementia with Lewy bodies shows incidence is higher than that of other uncommon neurological disorders.

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First Clear Win for BTK Inhibitors in Relapsing MS

After previous disappointments with BTK inhibitors, a novel drug in this class is the first to show superiority to an active comparator for relapsing MS outcomes.

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