Study: Cholesterol was lowered with an oral PCSK9 inhibitor.

Published Date: 08 Mar 2023

A new study conducted by Baylor College of Medicine and presented at the American College of Cardiology Annual Scientific Session as well as the World Congress of Cardiology shows that an oral PCSK9 inhibitor called MK-0616...

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Pregnancy Hypertensive Disorders Recur in 15% of Women

The subsequent episode links to a history of severe early-onset hypertensive disorders of pregnancy.

Long-Term Primary Care Linked to Fewer Emergency Admissions

Findings suggest that maintaining stable primary care relationships may support earlier intervention and more efficient use of hospital services.

Amputation Tied to Doubled Death Risk in T2D

Patients with type 2 diabetes who undergo lower-extremity amputation have more than double the risk for all-cause and cardiovascular death, independent of established cardiovascular risk factors.

Smarter Clot Testing Cuts Transfusions in Liver Disease

Guiding transfusion decisions with viscoelastic clot testing rather than standard blood counts reduces unnecessary transfusions among patients with cirrhosis without increasing the risk for bleeding.

1 in 5 Kids on Long-Term VADs Still Supported at 2 Years

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‘Modest’ Differences in OAT Should Not Obscure Benefits

Methadone may be linked to a lower risk for death than buprenorphine-naloxone in the short term, but after an overdose, either opioid agonist therapy is better than none.

Talc Powder Not Linked to Lung Cancer in Women

A study of US women finds no connection between talc powder use and lung cancer, though subgroup findings leave questions open.

Todays Updates

‘Modest’ Differences in OAT Should Not Obscure Benefits

Methadone may be linked to a lower risk for death than buprenorphine-naloxone in the short term, but after an overdose, either opioid agonist therapy is better than none.

Talc Powder Not Linked to Lung Cancer in Women

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Latest News

A phase 2 study evaluates the safety and efficacy of adding venetoclax to chemoimmunotherapy for patients with newly diagnosed double-hit lymphoma.

The subsequent episode links to a history of severe early-onset hypertensive disorders of pregnancy.

Findings suggest that maintaining stable primary care relationships may support earlier intervention and more efficient use of hospital services.

Patients with type 2 diabetes who undergo lower-extremity amputation have more than double the risk for all-cause and cardiovascular death, independent of established cardiovascular risk factors.

Guiding transfusion decisions with viscoelastic clot testing rather than standard blood counts reduces unnecessary transfusions among patients with cirrhosis without increasing the risk for bleeding.

Nearly 1 in 5 children with ventricular assist devices remain on support for more than 6 months, and among that group, 1 in 5 patients are still on the device at 2 years.

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Vascular Disease May Raise Apathy Risk in People With HIV

Vascular disease is independently associated with more frequent and severe symptoms of apathy among people with HIV.

Heart Stress May Predict CVD and Death Risks in Older Adults

Developing or continuing to experience heart stress over time is associated with increased risks for cardiovascular disease and death in older adults.

CKM Syndrome Tied to Major Blinding Eye Diseases

Cardiovascular-kidney-metabolic syndrome is associated with an increased risk of developing major blinding eye diseases in a large UK cohort, with stage 3 showing the highest rates.

Is DTG/3TC Comparable to Triple Therapy in High Viral Load?

Dolutegravir/lamivudine shows comparable virologic suppression to bictegravir/emtricitabine/tenofovir alafenamide in HIV with very high viral loads, with no significant difference between the regimens.

Usual Tests May Miss Risks in Mild Pulmonary Hypertension

In patients with mild pulmonary hypertension, measures of pulmonary artery stiffness and right-ventricular function may predict survival better than traditional measures do.

Late Bleeding Events After PCI Tied to Higher Death Risk

After PCI, both ischaemic and bleeding complications are tied to a higher risk for death, but bleeding events occurring months after discharge carry a higher risk for death than late ischaemic events.

1-Year Tirzepatide, Ixekizumab Combo Trial Results Reported

Results from phase 3b trials show a greater benefit at 52 weeks for patients with psoriasis or psoriatic arthritis treated with ixekizumab plus tirzepatide vs ixekizumab alone.

Certain Social Factors Tied to Metabolic Liver Disease

Food insecurity and neighborhood deprivation were each independently associated with higher incidence of MASLD, with the highest incidence among adults experiencing both.

Medicaid Expansion May Not Curb Severe Maternal Morbidity

Medicaid expansion is linked to an increased proportion of deliveries covered but is not associated with a reduction in severe maternal morbidity during delivery hospitalization.

Transplant Recipients May Face Higher Endocarditis Mortality

Transplant recipients with infective endocarditis have a distinct microbiological profile and face a significantly higher risk for death at 1 year than non‑transplant control participants.

Sports Unite Doctors in Spain and Beyond

Medical soccer, cycling, and marathon running are helping physicians build camaraderie, stay active, and strengthen professional networks beyond the hospital.

As GLP-1s Revolutionize Obesity Care, Access Remains Uneven

GLP-1 drugs have moved rapidly into the mainstream, but recent data show that many ideal patients are still being left behind.

Deep Dive: Two New Drugs, One Disease: MASLD's Three-Specialty Shift

Beyond Gastroenterology: FDA Approvals and Updated Guidelines Shift Frontline MASLD Care to Primary Medicine and Endocrinology

Mechanical VT Risk Factors Tied to Young Stroke

Recent mechanical venous thrombosis risk factors are linked to cryptogenic ischemic stroke in younger adults, particularly those with patent foramen ovale, study shows.

The Secret Weapon That Eliminated Doubt I Was a Good Doctor

A hematologist oncologist came from humble roots in a different culture and had to learn what internal strengths she possessed to succeed in medicine. She never looked back.

Clonal Hematopoiesis Tied to Brain Damage in AF

In patients with atrial fibrillation, clonal hematopoiesis was linked to hidden brain damage and faster mental decline over 7 years.

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