Study: Cholesterol was lowered with an oral PCSK9 inhibitor.

Are Beef Tallow and Zone 2 Training Worth the Hype?

Evidence supports replacing saturated fat with unsaturated fat and improving cardiorespiratory fitness, but neither trend has evidence for the categorical claims made online.

SCA Shown to Strike Young Athletes Mostly During Training, Practice

A new study highlights the need to expand emergency response efforts for sudden cardiac arrest in young athletes.

Early Menopause Leaves Lasting Trace on Brain

Antiplatelet Therapy vs Thrombolysis in Spinal Infarction

In spontaneous spinal cord infarction, standard antiplatelet therapy was associated with significantly lower all-cause mortality compared with thrombolytic treatment.

Heart Imaging Measures May Flag SCD Risk in HFmrEF

The extent of late gadolinium enhancement and tissue damage on cardiac imaging may help predict risk for sudden cardiac death in patients with heart failure with mildly reduced ejection fraction.

Heart Stress May Predict CVD and Death Risks in Older Adults

Developing or continuing to experience heart stress over time is associated with increased risks for cardiovascular disease and death in older adults.

Vascular Disease May Raise Apathy Risk in People With HIV

Vascular disease is independently associated with more frequent and severe symptoms of apathy among people with HIV.

Deep Dive: SSRIs: Precision Rx Meets the Deprescribing Question

The largest pharmacogenomic SSRI trial yet meets a deprescribing evidence base that cuts both ways; psychologist John Read still calls current prescribing patterns a public health problem.

CKM Syndrome Tied to Major Blinding Eye Diseases

Cardiovascular-kidney-metabolic syndrome is associated with an increased risk of developing major blinding eye diseases in a large UK cohort, with stage 3 showing the highest rates.

1-Year Tirzepatide, Ixekizumab Combo Trial Results Reported

Results from phase 3b trials show a greater benefit at 52 weeks for patients with psoriasis or psoriatic arthritis treated with ixekizumab plus tirzepatide vs ixekizumab alone.

Late Bleeding Events After PCI Tied to Higher Death Risk

After PCI, both ischaemic and bleeding complications are tied to a higher risk for death, but bleeding events occurring months after discharge carry a higher risk for death than late ischaemic events.

Usual Tests May Miss Risks in Mild Pulmonary Hypertension

In patients with mild pulmonary hypertension, measures of pulmonary artery stiffness and right-ventricular function may predict survival better than traditional measures do.

Is DTG/3TC Comparable to Triple Therapy in High Viral Load?

Dolutegravir/lamivudine shows comparable virologic suppression to bictegravir/emtricitabine/tenofovir alafenamide in HIV with very high viral loads, with no significant difference between the regimens.

Certain Social Factors Tied to Metabolic Liver Disease

Food insecurity and neighborhood deprivation were each independently associated with higher incidence of MASLD, with the highest incidence among adults experiencing both.

Transplant Recipients May Face Higher Endocarditis Mortality

Transplant recipients with infective endocarditis have a distinct microbiological profile and face a significantly higher risk for death at 1 year than non‑transplant control participants.

Medicaid Expansion May Not Curb Severe Maternal Morbidity

Medicaid expansion is linked to an increased proportion of deliveries covered but is not associated with a reduction in severe maternal morbidity during delivery hospitalization.