Can a Constipation Drug Clear Depression’s ‘Brain Fog’?

Published Date: 23 Jun 2026

A proof-of-concept study suggests the 5-HT4 receptor agonist prucalopride, which is approved for chronic constipation, improves cognition in patients with remitted depression.

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S4 Episode 6: Can Diet Improve Psoriasis Outcomes?

Many patients ask whether changing what they eat can help their psoriasis. Dr Joel Gelfand reviews the MEDIPSO trial and explains when a Mediterranean diet may meaningfully improve disease severity.

What Algorithms Cannot Heal: The Future of Rural Dermatology

Geographic barriers delay diagnoses, worsen outcomes, and increase morbidity from inflammatory skin disease and mortality from skin cancer, and patients often travel hours for specialty care.

Frailty Tied to Complications After Incontinence Surgery

Frailty is associated with complications and mortality within a year after stress urinary incontinence surgery in older men.

Guideline Update: Thyroid Disease in Pregnancy

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Starting Over: What Changing Practices Taught Me About Trust

Vaccine hesitancy and misinformation get the blame for declining patient trust, but Dr Kenny Lin argues a major factor is being overlooked: disappearing continuity of care.

Radiation Deserts Grow as Rural Radiation Sites Are Lost

More than 50 million Americans live in counties without a radiation oncology practice site as rural and community-based centers disappear at higher rates.

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Palliative Care Remains Uncommon in Young Adults With Cancer

Concurrent palliative care use among young adults with advanced cancer is less than 20%, with substantial variation across cancer types.

Todays Updates

Palliative Care Remains Uncommon in Young Adults With Cancer

Concurrent palliative care use among young adults with advanced cancer is less than 20%, with substantial variation across cancer types.

Latest News

Many patients ask whether changing what they eat can help their psoriasis. Dr Joel Gelfand reviews the MEDIPSO trial and explains when a Mediterranean diet may meaningfully improve disease severity.

Geographic barriers delay diagnoses, worsen outcomes, and increase morbidity from inflammatory skin disease and mortality from skin cancer, and patients often travel hours for specialty care.

Frailty is associated with complications and mortality within a year after stress urinary incontinence surgery in older men.

Drs Kaniksha Desai and Angela Leung discuss the new guidelines for thyroid disease in preconception, pregnancy, and postpartum.

Vaccine hesitancy and misinformation get the blame for declining patient trust, but Dr Kenny Lin argues a major factor is being overlooked: disappearing continuity of care.

More than 50 million Americans live in counties without a radiation oncology practice site as rural and community-based centers disappear at higher rates.

News All Time

Both Sides of the Bars: Jail Reform as Mental Health Policy

Jails have become de facto psychiatric institutions. Dr Temitope Ogundare explains why psychiatrists should help prevent incarceration — not just treat its consequences.

The Challenge With Health Data Is Using It Well

An international survey finds physicians are ready to use wearable health data. The bigger challenge is building the systems to turn that information into better care.

Sickle Cell Disease Linked to Higher Postpartum LARC Use

People with sickle cell disease received immediate postpartum long-acting reversible contraception at more than three times the rate of those without the condition, even after adjusting for clinical and demographic factors.

Should Age Trigger Physician Screening? Many Doctors Say No

A Medscape commentary asks whether older physicians should be tested for competence. Readers answer with a question of their own: Why single out age?

Microteams Tied to Better Continuity of Care in Primary Care

Implementation of a microteams model is associated with an increase in consultations with GPs, indicating improved continuity of care.

Parkinson's Care Gaps: Do Immigrant Patients Face Barriers?

Immigrant patients with Parkinson's disease have clinical profiles similar to native patients but are less likely to attend follow-up visits and adhere to treatment, a Spanish study shows.

Indigenous Canadians Face Cancer Survival Inequalities

Breast, colon, and cervical cancer incidence and mortality have improved for First Nations patients, but survival is significantly lower than that of other Ontario residents.

No Vitamin K Shot at Birth May Up Infant Bleeding Risk

Infants who do not receive intramuscular vitamin K prophylaxis at birth have higher odds of bleeding episodes and intracranial hemorrhage during the first 6 months of life.

Medicaid Patients Half as Likely to Get Menopause Meds

Women with private insurance were twice as likely to report a history of hormone therapy for menopause than those covered by Medicaid.

At-Home Lecanemab: ‘Encouraging’ First Data

Early real-world data suggest that weekly at-home subcutaneous lecanemab may offer a feasible alternative to ongoing IV maintenance treatment for early Alzheimer’s disease.

Adult-Gerontology Nursing the Future of Elder Care

Adult-gerontology nurse practitioners might be the future of elder care as opportunities grow.

CSF Biomarker Panel May Improve Diagnosis of CNS Lymphoma

A prospective multicenter study validates three cerebrospinal fluid biomarkers that may aid diagnosis of suspected primary CNS lymphoma.

Health Data Platform Connects Hospitals Across Provinces

The VITAL system collects near real-time hospital data with the aim of optimizing healthcare delivery, research, and innovation while protecting privacy.

Blood Test Flags Gynaecologic Cancer Risk in NHS Trial

A blood test correctly flags 99% of gynaecologic cancers as high risk in the largest NHS AI triage trial yet.

Focal Therapy Shows Favorable Long-Term Outcomes

A large registry study finds low 10-year prostate cancer mortality after focal HIFU or cryotherapy, but experts caution randomized comparisons with standard treatments are needed.

Parental Anxiety Persists Up to 2 Years After NICU Discharge

Parents of extremely premature infants show higher anxiety levels well beyond hospital discharge.

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